Clinical trials: Cortisol
Preeclampsia, Stress, Psychological
Stress Reduction in Formerly Preeclamptic Women; Sofa or Sports
The goal of this clinical trial is to evaluate stress and cardiovascular risk factors in women with preeclampsia in the medical history.
- Conditions
- Preeclampsia, Stress, Psychological, Stress, Physiological, Sports Physical Therapy
- Trial name
- SOS (NCT06402604)
- Testing
- Aerobic exercise training, Mindfulness Based Stress Reduction training
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healhty
Autonomic and Peripheral Neurochemical Responses to Maximal Rowing Exercise
The goal of this observational study is to characterize autonomic, neuroendocrine, and peripheral neurochemical responses to maximal rowing exercise and early recovery in highly trained male athletes.
- Trial name
- NCT07661953
- Testing
- Maximal 6,000-m rowing ergometer test
- Where
- Poland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Bariatric Surgery, Virtual Reality
The Effect of Virtual Forest Bathing on Bariatric Surgery Patients
This study will be conducted at the General Surgery Clinic of City Hospital in Erzurum between August 2025 and April 2026 using a randomized controlled experimental design.
- Conditions
- Bariatric Surgery, Virtual Reality, Anxiety
- Trial name
- NCT07152054
- Testing
- virtual forest bathing
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Healthy
Glucose Metabolism and Quality of Life in Healthy Women
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women. Women with PCOS often have problems with fertility, unwanted hair growth, and irregular menstrual cycle.
- Trial name
- Healthywomen (NCT01995773)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Rheumatoid Arthritis
Cortisol Circadian Rhythm in Patients With RA
The European League Against Rheumatism (EULAR), acknowledging the critical issue of the complications, of long term treatment with glucocorticoids in the most recent update of the management guidelines for Rheumatoid arthritis…
- Trial name
- CortRyRA (NCT05671627)
- Testing
- DMARDs
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Agoraphobia; Panic, Social Anxiety Disorder
Differential Effects of in Vivo and Virtual Exposure Therapy in Agoraphobia
Anxiety disorders, including agoraphobia, are prevalent in the German population, leading affected individuals to avoid specific places like crowds or public transport.
- Trial name
- VRExpo (NCT06514495)
- Testing
- Therapy
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Wellbeing, Healthy
PROMOTE: The Effect of a Six Week Prebiotic Supplementation on Wellbeing of Young Adults.
The study will investigate whether taking a prebiotic for six weeks helps to reduce morning cortisol levels in healthy young adults with mild to moderate stress compared to a placebo.
- Conditions
- Wellbeing, Healthy, Mental Health
- Trial name
- PROMOTE (NCT06566157)
- Testing
- Prebiotic, Maltodextrin (Corn)
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southampton
Premature Birth, Low Birth Weight
Pilot Trial of CenteringPregnancy With Mindfulness Skills
In the U.S., rates of preterm birth and low birth weight have increased over the past 30 years. Poor birth outcomes are especially high among racial/ethnic minority populations.
- Conditions
- Premature Birth, Low Birth Weight, Postpartum Depression
- Trial name
- NCT01646463
- Testing
- CenteringPregnancy, CenteringPregnancy with Mindfulness Skills
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dietary Modification
Randomized Controlled Experiment of Dieting in Pairs
This study examined how dieting with a partner affects weight loss, diet adherence, psychological well-being, and cortisol.
- Trial name
- NCT02898844
- Testing
- Mixed Diet Condition, Both Diet Condition
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- A. Janet Tomiyama
Stress, Signs and Symptoms, Digestive
The Acute Effect of Coffee Consumption on Stomach, Self-reported Gastrointestinal Symptoms and Stress.
This study investigated the acute effect of the consumption of four different kinds of coffee (hot and cold instant coffee, cold espresso and hot filter coffee) with the same caffeine content on salivary gastrin, cortisol and…
- Conditions
- Stress, Signs and Symptoms, Digestive, Blood Pressure, Increased Secretion of Gastrin
- Trial name
- NCT02253628
- Testing
- Cold espresso, Hot instant coffee, Cold instant coffee
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Cannabis Use, Cannabis
Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users
This research project proposes a novel approach to elucidate the biological adaptations associated with heavy cannabis use and to assess whether such adaptations are predictive of higher cannabis craving in response to both…
- Conditions
- Cannabis Use, Cannabis, Cannabis Abuse
- Trial name
- CLR2 (NCT05833230)
- Testing
- Intensive Day Monitoring
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yale University
Cortisol
Effect of MIST on Esophageal Sensitivity: Pilot Study
Influence of placing the esophageal probe on the cortisol response. Number of cortisol (non)responders and association of heart rate and subjective perception of stress with cortisol levels.
- Trial name
- PilotMIST (NCT05760872)
- Testing
- Placing esophageal probe
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Immunosuppression, Healthy
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers
Background: Corticosteroids have been used to treat inflammation and immune system diseases for decades. However, despite their widespread use, there is little information on the specifics of how corticosteroids affect the immune…
- Conditions
- Immunosuppression, Healthy, Healthy Subjects
- Trial name
- NCT01281995
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Overweight and Obesity
Study of the Effects of Overfeeding on Glucocorticoids in Lean and Obese Subjects
Investigators suggest that in lean subjects cortisol increases in response to overfeeding and that this increase is blunted in obese subjects.
- Trial name
- Gluco-Food (NCT04482738)
- Testing
- High-calorie meal
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Postoperative Pain, Subcostal Transversus Abdominis Plane Block
Effects of Subcostal TAP Block and Local Anesthetic Infiltration After Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy surgery is an intra-abdominal surgery that is frequently used in the treatment of gallbladder-related pathologies.
- Conditions
- Postoperative Pain, Subcostal Transversus Abdominis Plane Block, Gall Bladder Disease
- Trial name
- NCT05769881
- Testing
- Ultrasound guided subcostal transversus abdominis plane block, Wound site local anesthetic infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Exercise Physiology, Cardiorespiratory Fitness
IL-6 and Cortisol Responses to Cycling Exercise
This study aimed to investigate salivary interleukin-6 (IL-6) and cortisol responses following short-term and long-term cycling exercise in team athletes with different cardiorespiratory fitness levels.
- Conditions
- Exercise Physiology, Cardiorespiratory Fitness, Interleukin-6, Cortisol
- Trial name
- NCT07681362
- Testing
- Wingate Anaerobic Cycling Test, YMCA Submaximal Cycling Test
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Hypoactive Sexual Desire Disorder (HSDD)
Stress Hormones, Mood and Women's Sexual Desire (MODEST)
Women with Hypoactive sexual desire disorder (HSDD) have all measures of testosterone activity comparable to controls but lower levels of dehydroepiandrosterone (DHEA).
- Trial name
- MODEST (NCT01702818)
- Where
- Canada
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Dental Fear and Anxiety
Assessing the Efficacy of Lemongrass and Lavender Aromatherapy in Reducing Dental Anxiety and Pain Associated With Local Anesthetic Injections in Pediatric Dental Patients
The goal of this clinical trial is to evaluate whether aromatherapy using lemongrass or lavender essential oils can reduce dental anxiety and pain perception in children aged 7-11 years undergoing local anesthetic administration…
- Trial name
- NCT07113080
- Testing
- lavender essential oil inhaled using face mask, lemongrass essential oil inhaled using face mask
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hiba Ahmed Eltayeb
Sleep Bruxism
Evaluation of Muscle Activity, Bite Force and Salivary Cortisol in Children With Bruxism
Bruxism is a repetitive activity of the masticatory muscles characterized by grinding and/or clenching one's teeth or parafunctional movements of the mandible.
- Trial name
- Bruxism (NCT02757261)
- Testing
- Laser, Occlusal splint
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Depression
Stress Reactivity of Physical Stressor on Depression
Depressive elderly individuals have showed higher basal level of cortisol and lower level of dehydroepiandrosterone (DHEA). Moreover, changes on these hormone levels have also observed in reactivity of an acute stress, such as…
- Trial name
- NCT01791023
- Testing
- Physical exercise
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro