Clinical trials: Cortisol
PTSD
Cortisol Augmentation of a Psychological Treatment in Warfighters With Post Traumatic Stress Disorder (PTSD)
This study seeks to examine the efficacy of hydrocortisone administration in the augmentation of the therapeutic effects of Prolonged Exposure (PE) therapy, an empirically tested treatment shown to be effective in the the…
- Trial name
- NCT01090518
- Testing
- Prolonged Exposure therapy, Hydrocortisone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Bronx VA Medical Center
Healthy
Pharmacokinetics and Bioavailability of Hydrocortisone Acetate Suppositories
This study will be an open label, single dose, randomized, 2 way (2 period) crossover study in healthy adult subjects at a single study center.
- Trial name
- NCT02671058
- Testing
- Cortenema, Hydrocortisone Acetate
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cristcot LLC
Shock, Septic
Effects of Hydrocortison Treatment on Angiotensin II and Angiotensin II Receptors in Patients With Septic Shock
This study aims to evaluate the role of angiotensin II, AT1, and AT2 on catecholomine responsive and catecholomine resistant septic shock, and the effect of hydrocortisone traetment on catecholomine resistant septic shock and…
- Trial name
- NCT04647552
- Testing
- Drug Steroid
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Inonu University
Congenital Hydronephrosis, Congenital Choledochal Cyst
Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
Etomidate is an unique drug used for induction of general anesthesia and sedation. Adrenal cortical inhibition by etomidate has received much attention.
- Conditions
- Congenital Hydronephrosis, Congenital Choledochal Cyst, Fracture
- Trial name
- NCT02013986
- Testing
- etomidate, midazolam, propofol
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Du yi
Dietary Modification
Randomized Controlled Experiment of Dieting in Pairs
This study examined how dieting with a partner affects weight loss, diet adherence, psychological well-being, and cortisol.
- Trial name
- NCT02898844
- Testing
- Mixed Diet Condition, Both Diet Condition
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- A. Janet Tomiyama
Adrenal Insufficiency
A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjects
This was a two-part, single centre, open-label, randomised, single dose, two-period, crossover study to evaluate the bioavailability of Infacort® versus Cortef® immediate release hydrocortisone tablets in dexamethasone-suppressed…
- Trial name
- NCT03311932
- Testing
- Infacort®, Cortef®
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Primary Adrenal Insufficiency
Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency
Patients with chronic adrenal insufficiency need to adapt their hydrocortisone replacement dose in conditions of physical or psychological stress to prevent life threatening adrenal crisis.
- Trial name
- PHYSCA (NCT01450930)
- Testing
- Hydrocortisone intramuscular first, Hydrocortisone subcutaneously first
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Bruno Allolio
Diabetes Mellitus Type 2
Comparison of Progressive Muscle Relaxation and Stretching Exercises in Diabetic Population
The goal of this clinical trial is to compare the effects of Progressive muscle relaxation and stretching exercises mediated by stress on heart rate variability, cortisol level, galvanic skin response and perceived stress scale.
- Trial name
- NCT06780878
- Testing
- Progressive muscle relaxation technique, Stretching exercises, Control Group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Health
Acute Effects of Coffee on Appetite and Inflammation Markers, Glucose Metabolism and Energy Intake
The purpose of the study is to investigate whether caffeinated and decaffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and…
- Trial name
- NCT01174576
- Testing
- caffeinated and decaffeinated coffee
- Where
- Greece
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Adrenal Insufficiency
Hydrocortisone Versus Methylprednisolone for the Treatment of Glucocorticoid-Induced Adrenal Insufficiency
This study aims to compare the use of methylprednisolone and hydrocortisone as replacement therapies in patients with glucocorticoid-induced adrenal insufficiency.
- Trial name
- NCT07703098
- Testing
- Patients will receive 3 mg of methylprednisolone once daily. The dose is administered in the morning (1 ½ tablets of 2 mg Medrol after breakfast)., Patients will receive 15 mg of hydrocortisone daily. The dose is split into 10 mg in the morning after breakfast and 5 mg after 6-7 hours.
- Where
- Slovenia
- Volunteers
- 66 people
- Sponsor
- University Medical Centre Ljubljana
Ocular Inflammation, Ocular Prostheses
Comparison of Topical Treatment for Inflammatory Secretions of the Conjonctiva (Patients With Ocular Prostheses)
We propose to evaluate the efficacy of treatment with Hydrocortisone and Dexamethasone (in a cross-over design) in patients with ocular prostheses and significant functional discomfort.
- Trial name
- CRYSTAL (NCT05668455)
- Testing
- Hydrocortisone, Dexamethasone, Povidone
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Agnes
Pneumonia, Viral, Influenza in Humans
Low Doses Corticosteroids as Adjuvant Therapy for the Treatment of Severe H1N1 Flu
The H1N1 flu pandemic is one of the major infectious threat of the past half century. it is rapidly progressing worldwide and a substantial number of patients get severe H1N1 related pneumonia that requires mechanical ventilation…
- Trial name
- CORTIFLU (NCT01014364)
- Testing
- hydrocortisone, isotonic saline
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University of Versailles
Chronic Rhinosinusitis (Diagnosis)
Potential for Cortisol Suppression With the Use of High Volume Nasal Mometasone Irrigations in Varying Dosages.
In the United States, more than 30 million people are diagnosed with sinusitis each year. Moreover, chronic sinusitis effects approximately 15% of the U.S. population and is one of the most common chronic illnesses in America.
- Trial name
- NCT03979209
- Testing
- Nasal Mometasone Rinse
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Rush University Medical Center
Post Traumatic Stress Disorder
Efficacy of Single Dose IV Hydrocortisone in Post Traumatic Stress Disorder (PTSD) Prevention
This study is designed to test the hypothesis that a single Hydrocortisone intra venous injection within 6 hours post-trauma facilitates physiological recovery thereby preventing the development of Post Traumatic Stress Disorder…
- Trial name
- NCT00855270
- Testing
- Hydrocortisone
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
ADHD
Atomoxetine, Diurnal Profiles of Cortisol and α-amylase
Diurnal profiles of markers of the stress system are increasingly recognized as biomarkers of different kinds of depression and related states. They may also serve as markers of treatment success.
- Trial name
- ADHDstress (NCT03075579)
- Testing
- Medication Other, motor measurement and saliva collection
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Praxis für kleine und grosse Leute
Dental Anxiety
Effect of Virtual Reality Glasses as a Distraction Method on Child's Anxiety During Dental Treatment
The aim of the study is to evaluate and compare the effect of virtual reality glasses (VR) to conventional behavior management techniques as a distraction method on child's dental anxiety during dental treatment
- Trial name
- NCT04110379
- Testing
- Virtual Reality (VR), Conventional Behavior Management Techniques
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Nourhan M.Aly
Spine, Low Back Pain
Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain
The goal of this randomized cross-over mechanistic trial is to compare pre- and post-level cortisol and oxytocin changes in patients with chronic spine pain who receive either a hand's on (massage) or a hand's off (talk-based)…
- Conditions
- Spine, Low Back Pain, Neck Pain
- Trial name
- COTHA (NCT06987786)
- Testing
- Massage, Talk-based therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Horizontal Alveolar Ridge Deficiency, Partial Edentulism
Carrot Technique Versus Guided Bone Regeneration for Horizontal Ridge Deficiency in the Maxillary Esthetic Zone
This randomized controlled clinical trial aims to compare the effectiveness of the Carrot Technique and Guided Bone Regeneration (GBR) for the management of horizontal alveolar ridge deficiency in patients requiring implant…
- Trial name
- NCT07670559
- Testing
- Carrot Technique, Guided Bone Regeneration
- Where
- 2 sites in Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Depression
Stress Reactivity of Physical Stressor on Depression
Depressive elderly individuals have showed higher basal level of cortisol and lower level of dehydroepiandrosterone (DHEA). Moreover, changes on these hormone levels have also observed in reactivity of an acute stress, such as…
- Trial name
- NCT01791023
- Testing
- Physical exercise
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Obesity
The Influence of Induction Anesthetic Agents on Serum Cortisol Concentration in Morbidly Obese Patients.
The effect of etomidate administration on the adrenal cortex in obese patients is still unclear. The objective of the study was to determine the influence of single dose of etomidate on cortisol secretion in morbidly obese.
- Trial name
- NCT01930019
- Testing
- Intravenous administration of the induction agent of general anesthesia (etomidate or thiopental)
- Where
- Poland
- Volunteers
- 82 people
- Sponsor
- Military Institute od Medicine National Research Institute
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