Clinical trials: Cortisol
Healthy
Effect of Slow Release Hydrocortisone on Fed & Fasting Volunteers; Immediate Release on Fasting Only
The purpose of the study is to find out whether food has an effect on the way the body deals with modified release hydrocortisone, and to compare with the pharmacokinetics of immediate release hydrocortisone (fasted).
- Trial name
- NCT02408068
- Testing
- Dexamethasone, Chronocort: fasted, Immediate release hydrocortisone: fasted
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Bipolar Depression
RU-486 in the Treatment of Bipolar Depression
Bipolar disorder is a chronic and recurrent illness which involves episodes of mania and depression. It is believed that disturbance of the stress hormone system (the hypothalamic-pituitary-adrenal or HPA axis) may cause thinking…
- Trial name
- NCT00359125
- Testing
- mifepristone (RU-486)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Adrenal Insufficiency, Cushing Syndrome
Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
Cortisol is an essential for life hormone secreted in a pulsatile pattern on a diurnal rhythm. Given the complexity of cortisol secretion on a circadian rhythm with pulsations, current methods of cortisol measurement have…
- Conditions
- Adrenal Insufficiency, Cushing Syndrome, Hyperaldosteronism
- Trial name
- SensoCort (NCT06008184)
- Testing
- 24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva), 24 hours sampling of ISF or sweat (after validating the correlation with blood)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Healthy
Effects of Stress Hormones on Emotion and Cognition
The purpose of this study is to examine how hormonal changes that occur during stressful situations affect thought and emotions.
- Trial name
- NCT00032838
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cannabis Use, Cannabis
Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users
This research project proposes a novel approach to elucidate the biological adaptations associated with heavy cannabis use and to assess whether such adaptations are predictive of higher cannabis craving in response to both…
- Conditions
- Cannabis Use, Cannabis, Cannabis Abuse
- Trial name
- CLR2 (NCT05833230)
- Testing
- Intensive Day Monitoring
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yale University
Soft Tissue, Peri-Implant Health
Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone
An effective biological seal is crucial for protecting and supporting dental implants, particularly in the anterior region for the desired esthetic outcome.PRF membrane and CTG has been utilized to improve peri-implant soft…
- Conditions
- Soft Tissue, Peri-Implant Health, Soft Tissue Augmentation at Dental Implants, Connective Tissue Graft
- Trial name
- NCT07649239
- Testing
- Platelet rich fibrin multilayered Platelet-rich fibrin (PRF) A t the second stage, Soft tissue augmentation around dental implants with CTG in the second stage
- Where
- United Arab Emirates
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Cortisol
Effect of MIST on Esophageal Sensitivity: Pilot Study
Influence of placing the esophageal probe on the cortisol response. Number of cortisol (non)responders and association of heart rate and subjective perception of stress with cortisol levels.
- Trial name
- PilotMIST (NCT05760872)
- Testing
- Placing esophageal probe
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Infertility Unexplained, Fertility Disorders
Hypnofertility for Women Undergoing In Vitro Fertilization (HWUIVF)
This randomized controlled study aimed to specify whether the interventions based on Hypnofertility would lead to increased fertility preparedness and pregnancy outcomes, decreased cortisol levels of women undergoing In Vitro…
- Trial name
- NCT04141436
- Testing
- Interventions Based on Hypnofertility, Routine clinical procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Cortisol Resistance, Negative Feedback
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
This study proposes to examine multiple aspects of the hypothalamic-pituitary-adrenal axis in younger endurance trained and sedentary men, and in older sedentary men.
- Conditions
- Cortisol Resistance, Negative Feedback, ACTH, Mineralcorticoid
- Trial name
- NCT01294319
- Testing
- Mifepristone, Spironolactone, Combined
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Healthy
The Effect of Relaxation Response Training on Declarative Memory and Salivary Cortisol in Older Adults
To evaluate whether a 5-week relaxation response intervention influences the learning, memory or attention of healthy older adults.
- Trial name
- NCT00179530
- Testing
- Relaxation Response
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Quality of Life for Geriatric Patients.
Efficacy Study of Autosuggestion for Quality of Life of Geriatric Patients
The objective is to analyze the efficacy of autosuggestion for geriatric patients's quality of life and its impact to psycho-neuro-endocrine-immune pathways. The primary outcome is quality of life.
- Trial name
- ESAQoGe (NCT01681056)
- Testing
- Autosuggestion for 30 days
- Where
- Indonesia
- Volunteers
- 51 people
- Sponsor
- Universitas Indonesia
Pain
The Effect of Dexamedetomidine for Interscalene Brachial Plexus Block on Plasma Biomarkers After Rotator Cuff Repair
The present study was designed to test the hypothesis that dexmedetomidine added to ropivacaine for interscalene brachial plexus blocks for elective shoulder surgery would enhance the duration and effect of analgesia when…
- Trial name
- NCT02766556
- Testing
- dexmedetomidine, ISB, Ropivacaine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Cushings Syndrome
Saliva Cortisol Measurement as a Screening Test for Suspicious Cushings Syndrome in Children.
Cortisol overproduction ( Cushings syndrome) is a condition where the patient have a special fat distribution, with accumulation of fat around the abdomen and in the neck, with thinner limbs and weak musculature.
- Trial name
- NCT02646553
- Testing
- Children refered to the obesity clinic
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Haukeland University Hospital
Surgical Stress Response
The Effect of Music Played to Liver Transplant Donors During Surgery on Some Hemodynamic Values and Cortisol Levels
This randomized controlled trial investigates the effects of music played during liver donor surgery on hemodynamic parameters and cortisol levels.
- Trial name
- NCT06997237
- Testing
- Music Listening Intervention, Silence with Headphones
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hasan SARITAŞ
Adrenal Insufficiency
Adrenal Function in Critical Illness
An appropriate hypothalamic-pituitary-adrenal (HPA) axis response is required to survive critical illness. Primary adrenal insufficiency, relative adrenal insufficiency, tissue resistance to glucocorticoids, ACTH deficiency and…
- Trial name
- NCT00156767
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Overweight and Obesity
Study of the Effects of Overfeeding on Glucocorticoids in Lean and Obese Subjects
Investigators suggest that in lean subjects cortisol increases in response to overfeeding and that this increase is blunted in obese subjects.
- Trial name
- Gluco-Food (NCT04482738)
- Testing
- High-calorie meal
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Physiological Processes, Aging
Age-Related Changes in Stress Hormone Regulation
Studies investigating physiological processes involved in aging-related deficits in regulation of stress hormone systems.
- Trial name
- NCT00018369
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Overtraining Syndrome
Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes.
One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events.
- Trial name
- CHIPYA (NCT06150105)
- Testing
- Exercise training
- Where
- Poland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Anti-doping Campaign, Detection of Hydrocortisone
Administration of Hydrocortisone in Young Healthy Male Volunteers
The misuse of cortisone or hydrocortisone for doping purpose in sport has been widely reported in the literature, but to date, no formal testing procedure is available and applicable in an anti-doping laboratory to detect…
- Trial name
- H-CORT (NCT04137302)
- Testing
- Hydrocortisone administration
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Gastrointestinal, Microbiota Balance
The Effects of a Postbiotic Supplement on Biomarkers of Gut Health
This study is a randomized, double-blind, two-arm, placebo-controlled trial of N=80 (40/arm) apparently healthy men and women between 18 and 65 years old to be recruited at a single investigational center in Northeast Ohio (i.e.…
- Conditions
- Gastrointestinal, Microbiota Balance, Microbiota, Cortisol
- Trial name
- NCT07527286
- Testing
- Postbiotic
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Verb Biotics LLC
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