Clinical trials: Cortisol
Mild Autonomous Cortisol Secretion (MACS)
Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS)
To characterize the impact of Isturisa on clinical features and comorbidities associated with MACS. The investigators hypothesize that patients treated with Isturisa will exhibit significantly better metabolic indicators (such as…
- Trial name
- NCT07247058
- Testing
- Osilodrostat (Isturisa)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Postresuscitation Syndrome
HYdrocortisone and VAsopressin in Post-RESuscitation Syndrome
The primary objective is to demonstrate the superiority of arginine-vasopressin (AVP) and hydrocortisone compared with norepinephrine regarding day-30 survival and neurological recovery in post-cardiac arrest patients with…
- Trial name
- HYVAPRESS (NCT04591990)
- Testing
- Administration of AVP, Administration of hydrocortisone
- Where
- 14 sites in France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adrenal Insufficiency
Optimising Steroid Replacement in Patients With Adrenal Insufficiency
Adrenal insufficiency is a condition where the adrenal glands do not produce an adequate amount of steroid hormones. The aetiology of adrenal insufficiency can be primary or secondary.
- Trial name
- NCT03282487
- Testing
- Modified release hydrocortisone
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
Atopic Dermatitis
Adherence to Topical Hydrocortisone 17-butyrate 0.1% (Locoid®) Using Different Vehicles in Adults With Atopic Dermatitis
The purpose of this research study is to better understand adherence to Locoid when people use it to treat atopic dermatitis.
- Trial name
- NCT00693693
- Testing
- hydrocortisone 17-butyrate 0.1% Cream preparation, hydrocortisone 17-butyrate 0.1% Ointment preparation, hydrocortisone 17-butyrate 0.1% Lipocream preparation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Wake Forest University
Cocaine Dependence, Cocaine Addiction
A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction
Subjects will be randomly assigned to receive either one of the two potential dose combinations of the study medications or placebo over 6 weeks.
- Trial name
- NCT00567814
- Testing
- Metyrapone, Oxazepam
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Embera NeuroTherapeutics, Inc.
Septic Shock
Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock
The proposed study will evaluate the potential benefit of a tapered course of hydrocortisone compared to abrupt cessation in patients initiated on hydrocortisone for septic shock.
- Trial name
- NCT01150409
- Testing
- hydrocortisone, Normal Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The Cleveland Clinic
Adrenal Incidentaloma, Cortisol Overproduction
Morbidity and Mortality in Autonomous Cortisol Secretion
Benign enlargements of the adrenal glands (adrenal adenomas) are frequent in adults. In the general population these adenomas are rare in subjects below 40 years of age but at the age of 60 and 80 years the prevalence is 6 and…
- Trial name
- NCT03919734
- Where
- Sweden
- Volunteers
- 4,596 people
- Sponsor
- Region Skane
Shock, Septic, Critically Ill
The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial
Sepsis has been characterised as a dysregulated host response to infection. Adjunctive therapies targeting the inflammatory cascade are being increasingly explored, although to date, have failed to demonstrate consistent benefit…
- Conditions
- Shock, Septic, Critically Ill, Vasoplegic Syndrome, Sepsis
- Trial name
- VITAMINS (NCT03333278)
- Testing
- Vitamin C, Thiamine, Hydrocortisone,
- Where
- 8 sites in Australia, Brazil and 1 more
- Volunteers
- 216 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Endocrine Disorders
Salivary Cortisol Measurements by Mass Spectrometry
Cortisol is a hormone critical for survival in times of stress. Currently most measurements are done with blood samples. The hypothesis of this study is cortisol measured from saliva using mass spectrometry can be used to replace…
- Trial name
- NCT02162706
- Testing
- Non intervention study
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cognitive Impairment, Cognitive Decline
Music Therapy for Older Adults With Cognitive Decline Living in Care Homes
This research aims to investigate whether the use of music-improvisation therapy for older adult participants can lead to improvements in cognitive ability levels, especially in attentional functions.
- Trial name
- NCT05856604
- Testing
- Music Therapy, Storytelling
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Middlesex University
Endocrine Disease, Diabetes
Mifepristone Effects on Glucose Intolerance in Obese/Overweight Adults
Background: Metabolic syndrome is a name given to a group of factors that tend to occur together. These risk factors include central obesity (extra weight around the middle of the body) and high blood pressure and blood sugar…
- Trial name
- NCT01419535
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Arginine Vasopressin Deficiency, Diabetes Insipidus
Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls
This study aims to investigate the potential beneficial effects of intranasal oxytocin compared to placebo on emotion recognition and acute psychosocial stress in patients with arginine vasopressin deficiency compared to matched…
- Trial name
- OxyMOTION (NCT06676774)
- Testing
- Oxytocin nasal spray
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Addison's Disease
Exercise Capacity and Recovery in Addison's Disease
Exposure to stress alters the activity of the adrenomedullary, adrenocortical and sympathetic nervous system, depending on the type and intensity of the stressor.
- Trial name
- NCT01657123
- Testing
- ergometry
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Hypercortisolism, Arterial Hypertension
Cortisol Secretion, Sensitivity and Activity and Hypertension
The goal of this observational study is to evaluate, between patients with arterial hypertension and non hypertensive control group, the prevalence of hidden hypercortisolism the relationship between organ damage and oxidative…
- Trial name
- PRECOR (NCT05766085)
- Testing
- Dexamethasone suppression test
- Where
- Italy
- Volunteers
- 290 people
- Sponsor
- Istituto Auxologico Italiano
Total Knee Arthroplasty
Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty
One postoperative complication following unilateral or bilateral total knee arthroplasty is thrombosis (blood clot formation). In this prospective, double-blinded randomized controlled clinical trial, researchers are…
- Trial name
- NCT01815918
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Focus of Study is on Insomnia Among Diabetic Patients
Comparison of Mg Vs. K Supplementation on Insomnia in Diabetics
Insomnia is increasing alarmingly among the population. Micronutrient fluctuations have been shown to effect insulin secretion, period of circadian cycle and quality of sleep in all ages.
- Trial name
- NCT04642313
- Testing
- Magnesium and/ or Potassium
- Where
- 2 sites in Pakistan
- Volunteers
- 320 people
- Sponsor
- University of Lahore
Addison Disease
Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal Failure
The conventional glucocorticoid replacement therapy in primary adrenal insufficiency- Addison's disease,renders the cortisol levels unphysiological, which may cause symptoms and long-term complications.
- Trial name
- NCT01847690
- Testing
- Hydrocortisone
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Brain Concussion
Tissue Repository and Master Database for Concussion Biomarker and Risk Calculator Development
The purpose of this study is to prospectively collect a comprehensive, multi-modality set of diagnostics on patients who have had a concussion, repeating some of these tests serially over time, so that the investigators may then…
- Trial name
- NCT02519998
- Testing
- Concussion
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Acute Myocardial Infarction
Hair Cortisol and the Risk of Acute Myocardial Infarction
Aim of the study: To evaluate whether hair cortisol levels are elevated in patients admitted with acute MI compared to controls. Study steps: 1. Introduction of the study to the participants and inform consent signing 2.
- Trial name
- NCT00682487
- Testing
- Hair sampling for cortisol
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Meir Medical Center
Combat Disorders, Posttraumatic Stress Disorder
Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms
The goals of the proposed research are to produce preliminary evidence of PE with OEF/OIF veterans with PTSD and to examine cognitive, psychophysiological, and neuroendocrine mechanisms of change in PTSD treatment.
- Trial name
- NCT00475241
- Testing
- Prolonged Exposure therapy for PTSD, Present centered therapy for PTSD
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.