Clinical trials: Cortisol Deficiency
Hypopituitarism, Central Diabetes Insipidus
Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Hypopituitarism, Central Diabetes Insipidus, Panhypopituitarism, Psychological Disorder
- Trial name
- NCT04902235
- Testing
- Experimental: CRH administration
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Autism Spectrum Disorder With Intellectual Deficiency
Recording Stress Biomarkers in Autism Spectrum Disorders
The goal of this observational study is to learn how stress affects children and young people with autism spectrum disorder (ASD).
- Trial name
- STRESSDEFIS (NCT07535801)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universite Cote d'Azur
Adrenal Insufficiency
Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.
Patients with adrenal insufficiency are most often overdosed with hydrocortisone. To date, there is no reliable marker that can reflect the quality of hydrocortisone substitution.
- Trial name
- NCT05457296
- Testing
- Hydrocortisone (capsule)
- Where
- 2 sites in Tunisia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Sleep, Mood
Tryptophan Supplementation to Improve Night Shift Workers' Health
This randomized cross-over double-blinded trial aims to investigate the health effect of oral l-tryptophan supplementation on workers who rotate night shift work, and to examine the influences of different frequencies and timings…
- Conditions
- Sleep, Mood, Burnout, Melatonin Deficiency
- Trial name
- NCT04505800
- Testing
- Tryptophan supplement, Maltose
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Healthy Volunteer Study, HPA
Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function
This study aims to investigate the effects of a single dose of the glucagon-like 1 receptor agonist semaglutdie/Rybelsus on the hypothalamo-pituitary-adrenal axis, thus cortisol levels and other stresshormones in healthy males.
- Conditions
- Healthy Volunteer Study, HPA, Cortisol Deficiency, Adrenal Insufficiency
- Trial name
- PIANO (NCT06608433)
- Testing
- semaglutide
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Arginine Vasopressin Deficiency, Diabetes Insipidus
Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls
This study aims to investigate the potential beneficial effects of intranasal oxytocin compared to placebo on emotion recognition and acute psychosocial stress in patients with arginine vasopressin deficiency compared to matched…
- Trial name
- OxyMOTION (NCT06676774)
- Testing
- Oxytocin nasal spray
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Adrenal Hyperplasia, Congenital, 21-hydroxylase Deficiency
Adrenocortical Functions in Women With Nonclassical 21-hydroxylase Deficiency.
The risk of adrenal insufficiency in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency is not well documented.
- Trial name
- EVAF-21 (NCT01862380)
- Testing
- Functional explorations
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris