Clinical trials: Cost Effectiveness
Elective Reconstructive Surgery Population
The Effect of Healing Touch on Sleep
Healing Touch improves measures of sleep the night prior to surgery, thus improving surgery-related morbidity.
- Trial name
- Sleep7 (NCT01870076)
- Testing
- Healing Touch, Control, Presence
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
HIV Infections
Implementation a Data-to-Care Strategy to Improve HIV Continuum Outcomes for Out of Care People Living With HIV (PLWH) in Ukraine
The goal of this clinical trial is to study the preliminary effectiveness of a data to care intervention versus standard of care for people living with HIV in Ukraine.
- Trial name
- NCT05821413
- Testing
- Data to care, Standard of Care
- Where
- Ukraine
- Volunteers
- 160 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Major Depressive Disorder
VA Augmentation and Switching Treatments for Improving Depression Outcomes
The overall purpose is to determine research based 'next-steps' for outpatients with major depressive disorder who have not had satisfactory outcomes to standard 'first-step' treatments.
- Trial name
- VAST-D (NCT01421342)
- Testing
- Switching: Bupropion-SR, Augmenting: Antidepressant + Bupropion-SR, Augmenting: Antidepressant + Aripiprazole
- Where
- 35 sites in United States
- Volunteers
- 1,522 people
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis, Hip Osteoarthritis
Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties
Barbed sutures offer several potential advantages in layered wound closure of hip and knee replacement surgeries. It use is gaining increased acceptance across many of the other surgical disciplines at this time.
- Trial name
- NCT00834483
- Testing
- Knotless suture for wound closure, Layered traditional wound closure (monocryl)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Migraine
Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine
Subjects enrolled at 2 investigative sites will complete 3 visits. Following Visit 1, during a 1-month Baseline Period, subjects will treat with their usual medication and document any warning signs (Prodrome pre-headache) that a…
- Trial name
- NCT00846495
- Testing
- topiramate, frovatriptan
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Clinvest
Cancer
S1204, Viral Screening in Newly Diagnosed Cancer Patients
The goal of this study is to estimate the prevalence of HIV, Hepatitis B and hepatitis C infection among newly diagnosed cancer patients presenting to community and academic oncology clinics.
- Trial name
- NCT01946516
- Where
- 58 sites in United States
- Volunteers
- 3,051 people
- Sponsor
- SWOG Cancer Research Network
Diabetic Macular Edema
Safety, Efficacy and Cost-efficacy of Ranibizumab (Monotherapy or Combination With Laser) in the Treatment of Diabetic Macular Edema (DME)
To evaluate, specifically within the Canadian medical environment, the efficacy, safety and cost-efficacy of ranibizumab administered either as combination therapy (ranibizumab plus laser photocoagulation), or as monotherapy in…
- Trial name
- RESPOND (NCT01135914)
- Testing
- ranibizumab, Laser
- Where
- 20 sites in Canada
- Volunteers
- 241 people
- Sponsor
- Novartis Pharmaceuticals
Physical Activity
Testing Adaptive Interventions to Improve Physical Activity for Sedentary Women
This study employs a Sequential Multiple Assignment Randomized Trial (SMART) and aims to determine the most effective adaptive intervention combining four efficacious treatments (enhanced physical activity monitor, motivational…
- Trial name
- NCT03558828
- Testing
- Step 1: PA Monitor, Step 1: PA Monitor + Text, Step 2: PA Monitor with Calls
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Inflammatory Bowel Diseases
Safety of Reduced Infliximab Infusion Time
Remicade is a common medicine used for the treatment of inflammatory bowel disease. This medication is given as an intravenous infusion over 2 hours. Studies have suggested it is safe to give the infusion at a faster rate.
- Trial name
- NCT05340764
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Washington University School of Medicine
Sunburn, Erythema, Sun Protection
UV Exposure Assessed With Wearable Sensor and Sun Protection
The goal is to prevent ultraviolet light (UV) overexposure by providing consumers with relevant, easy-to-access, specifically actionable information.
- Trial name
- NCT03344796
- Testing
- Goal attainment
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Scar
Comparison of Lasers in the Treatment of Scars
The purpose of this study is to compare the 1550-nm non-ablative Fraxel laser (referred to as Fraxel Laser in this application) to the ablative 10,600-nm carbon dioxide fractional laser (referred to as CO2 Laser in this…
- Trial name
- NCT02988622
- Testing
- Fraxel Laser, CO2 Laser
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Marta Hemmingson-Van Beek
Intermittent Claudicants
Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants
The investigators are conducting a randomised controlled trial to investigate the clinical and cost effectiveness of Ramipril which is an anti-hypertensive medication in patients with intermittent claudication.
- Trial name
- NCT01037530
- Testing
- Ramipril
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Diabetes, Hypertension
Can Group Visits Improve Outcomes of Veterans With Diabetes
Background: Diabetes is a common, morbid and expensive disease among veterans. Achieving adequate glycemic control and blood pressure control can reduce the devastating complications of diabetes.
- Trial name
- NCT00286741
- Testing
- Diabetes Group Management Visits
- Where
- 2 sites in United States
- Volunteers
- 239 people
- Sponsor
- US Department of Veterans Affairs
Stroke
Interdisciplinary Team Approach to Stroke Rehabilitation in Home Care
As the population ages and the number of stroke survivors increases, information is needed to determine the best way of providing home care services for rehabilitation to stroke survivors and their caregivers while containing…
- Trial name
- NCT00463229
- Testing
- Interprofessional Team Approach
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- McMaster University
Thoracoabdominal Aortic Aneurysm
Safety, Efficacy, Longitudinal Costs and Patient-Centered Outcomes Using a TAAA Debranching Device
The primary purpose of this study is to assess the use of the TAAA Debranching Stent Graft System to repair thoracoabdominal aortic aneurysms in patients having appropriate anatomy, as measured by device safety, effectiveness…
- Trial name
- NCT03637374
- Testing
- Visceral Manifold and Thoracic Bifurcation, Unitary Manifold, TAAA Debranching Stent Graft System
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
PreDiabetes, Hyperglycemia
Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs
The purpose of this research study is to compare the effectiveness of a fully automated digital diabetes prevention program to standard of care human coach-based diabetes prevention programs for promoting clinically meaningful…
- Conditions
- PreDiabetes, Hyperglycemia, Glucose, High Blood, Overweight
- Trial name
- NCT05056376
- Testing
- Digital Diabetes Prevention Program (dDPP), Human Coach-based Diabetes Prevention Program (hDPP)
- Where
- 2 sites in United States
- Volunteers
- 368 people
- Sponsor
- Johns Hopkins University
HIV, Hypertension
SEARCH SAPPHIRE Phase A: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa
The randomized trials in this record will assess effectiveness, fidelity and cost of prevention and treatment interventions for HIV and hypertension with the objective of informing a population-based study of multi-sectored…
- Conditions
- HIV, Hypertension, Alcohol Drinking, Maternal Child Health
- Trial name
- SAPPHIRE PhA (NCT04810650)
- Testing
- Mobility Dynamic Treatment Intervention, Health Living Intervention for Heavy Alcohol Users, Hypertension Linkage
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 2,233 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV, Tuberculosis
Sustainable East Africa Research in Community Health
The SEARCH study aims to test evidenced-based innovative community based interventions that lead to the elimination of HIV in rural communities in East Africa using a multi-disease approach.
- Conditions
- HIV, Tuberculosis, Hypertension, Diabetes
- Trial name
- SEARCH (NCT01864603)
- Testing
- Universal ART in a streamlined care model, Annual Community Health Campaigns, Targeted PrEP and Targeted testing interventions
- Where
- 3 sites in Kenya, Uganda
- Volunteers
- 150,395 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gonorrhea, Chlamydia
Adolescent Sexually Transmitted Infection Screening in the Emergency Department
Sexually transmitted infections (STIs) are highly prevalent among adolescents. Clinical practices related to screening, diagnosis, treatment, and prevention of STIs among adolescents are suboptimal.
- Trial name
- STI (NCT03715335)
- Testing
- Targeted STI Screening, Universally Offered STI Screening
- Where
- 5 sites in United States
- Volunteers
- 98,413 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
HIV
Optimal Intervention to Full Viral Suppression: Text Me, Alexis!
Text Me, Alexis! is a three-arm randomized controlled trial (RCT) to determine the optimal and most cost-effective intervention for advancing trans women living with HIV to full viral suppression.
- Trial name
- NCT06408350
- Testing
- Text Me, Alexis!
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Friends Research Institute, Inc.