Clinical trials: Cost-Effectiveness
Cost Effectiveness, Exposure to Radiofrequency
Cost-effectiveness of RFA vs. PEI for Early-stage HCC
Introduction: Liver transplantation(LT) is the gold-standard treatment for unresectable early-stage HCC within the Milan criteria. However, long waiting time can lead to dropout from LT candidacy.
- Trial name
- NCT06450613
- Testing
- radiofrequency ablation, percutaneous ethanol injection
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Israelita Albert Einstein
Intracranial Aneurysms, Wide Neck Intracranial Aneurysms
Kaneka iED Coil System for the Treatment of Wide Necked Ruptured and Unruptured Intracranial Aneurysms
This is a multi-center, prospective, propensity matched twin armed study conducted on 50 patients in the experimental arm followed for 18 months after intervention evaluating cost effectiveness, safety and efficacy of therapy.
- Trial name
- CLASS (NCT05636124)
- Testing
- Kaneka i-ED coil
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Total Hip Arthroplasty, Osteoarthritis, Hip
Dual-mobility Cups Compared to Unipolar Cups on Dislocation and Cost-effectiveness After Primary Total Hip Arthroplasty.
Objective: The primary objective is to investigate whether there is a difference in the number of hip dislocations following primary total hip arthroplasty (THA), using the posterolateral approach, with a DM cup compared to a…
- Trial name
- REDEP (NCT04031820)
- Testing
- Unipolar cup, Dual mobility cup
- Where
- Netherlands
- Volunteers
- 1,100 people
- Sponsor
- JointResearch
Dementia
An In-home Respite Care Program to Support Informal Caregivers of People With Dementia
The general objective of this quasi-experimental study is to assess the effectiveness of an in-home respite care program compared to a control group not receiving the same type of in-home respite on the well-being of the…
- Trial name
- NCT02630446
- Testing
- in-home respite care program
- Where
- Belgium
- Volunteers
- 355 people
- Sponsor
- University Ghent
Postnatal Depression, Self Efficacy
Effectiveness of 'Supportive Parenting App' on Parental and Newborn Outcomes
The Supportive Parenting App is a theory-based perinatal educational intervention for couples administered through a mobile application.
- Conditions
- Postnatal Depression, Self Efficacy, Parent-Child Relations, Development, Child
- Trial name
- NCT04706442
- Testing
- Supportive Parenting Application
- Where
- Singapore
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Severe Haemophilia A
Efficacy and Cost Effectiveness of Pharmacokinetic Dosing in Haemophilia A
Patients with severe Haemophilia A need prophylactic factor VIII to reduce their risk of joint and soft tissue bleeds and to prevent or reduce joint damage.
- Trial name
- NCT02697370
- Testing
- Pharmacokinetic based dosage change
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Hampshire Hospitals NHS Foundation Trust
Alcohol Consumption, Drug-Food Interaction
Online Education to Inform the Elderly About Age-related Alcohol Risks
This proposed Phase 2 The Small Business Innovation Research study is a randomized trial of the effectiveness of "A Toast to Health in Later Life!" a web-based patient educational program designed to prevent hazardous and harmful…
- Trial name
- NCT02952495
- Testing
- Online alcohol educational class
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Arlene Fink Associates
Primary Spontaneous Pneumothorax (PSP), Conservative Management (Active Observation)
Conservative Management in Primary Spontaneous Pneumothorax: a Multicenter Randomized Non-inferiority Study
The goal of this randomized clinical trial is to find out whether a conservative management strategy (active observation without an initial invasive procedure) can treat as effectively as the standard treatment with chest tube…
- Trial name
- CONNEP (NCT07331805)
- Testing
- Conservative management (active observation), Chest tube drainage
- Volunteers
- 436 people
- Sponsor
- Corporacion Parc Tauli
Malaria Infection, Malaria Vaccines
Comparison of Two Strategies for Administering the R21-Matrix M Vaccine in a Context of Seasonal Malaria Transmission in Chad
This is a two-arm, cluster-randomised, phase IV trial conducted in Chad to assess the protective efficacy and impact in real-life conditions of a new strategy for administering the R21/MM malaria vaccine, synchronized within a…
- Trial name
- COSAV-R21 (NCT07038837)
- Testing
- "Synchronised" arm (intervention)
- Where
- Chad
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Epicentre
Compensated Liver Disease, Esophageal Varices
Baveno VIII Criteria for Portal Hypertension in Egyptian Patients
This prospective observational study aims to validate Baveno VIII criteria for detection of clinically significant portal hypertension and to evaluate additional predictors of esophageal varices in Egyptian patients with…
- Conditions
- Compensated Liver Disease, Esophageal Varices, Portal Hypertension, Chronic Liver Disease
- Trial name
- NCT07842666
- Volunteers
- 125 people
- Sponsor
- Assiut University
Body Dysmorphic Disorders
Internet-delivered Cognitive-behaviour Therapy for Child and Adolescent Body Dysmorphic Disorder
The purpose of this trial is to evaluate the clinical efficacy, the cost-effectiveness and the 6-month durability of a therapist-guided, Internet-delivered cognitive-behavior therapy programme for children and adolescents with…
- Trial name
- NCT06262412
- Testing
- Internet-delivered cognitive-behaviour therapy (ICBT), Internet-delivered relaxation treatment (IRT)
- Where
- 3 sites in Sweden
- Volunteers
- 154 people
- Sponsor
- Karolinska Institutet
Adrenal Incidentaloma, Adrenocortical Carcinoma
Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield
Standard diagnostic work-up for adrenal incidentalomas (AI) consists of periodical biochemical analysis and CT-scanning in case the initial work-up does not demonstrate the presence of hormonal hypersecretion or adrenocortical…
- Trial name
- SERENDIPITY (NCT02324647)
- Where
- Netherlands
- Volunteers
- 807 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Fall
Prevention of Falls Among Older Adults in Community Settings
Objective: To conduct a comparative efficacy and cost-effectiveness study of an evidence-based fall prevention program-Tai Ji Quan: Moving for Better Balance (TJQMBB).
- Trial name
- NCT02287740
- Testing
- Tai Ji Quan: Moving for Better Balance, Multimodal Exercise, Stretching
- Where
- United States
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Hiv
LA PrEP Impact and Cost-effectiveness (TEAMS)
This study will have three components: 1. Discrete choice experiments 2. Analysis of routine service data 3. Impact and cost-effectiveness analyses using results from 1 and 2
- Trial name
- NCT05774548
- Testing
- In-depth interviews (IDI), Focus group discussion (FGD)
- Where
- 12 sites in Thailand
- Volunteers
- 10,720 people, healthy volunteers welcome
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Anxiety, Somatoform Disorders
Evaluating the Cost Effectiveness of ISTDP: A Quasi Experimental Study
Objective: To evaluate whether or not cases treated with Intensive Short-term Dynamic Psychotherapy (ISTDP) facilitate healthcare cost reduction, whether any observed reduction is greater than that of a control group and whether…
- Conditions
- Anxiety, Somatoform Disorders, Personality Disorders, Depression
- Trial name
- CEISTDP (NCT01924715)
- Testing
- ISTDP
- Where
- Canada
- Volunteers
- 1,082 people
- Sponsor
- Nova Scotia Health Authority
HIV
Economic, Clinical and Quality of Life Assessment in Patients on Antiretroviral Therapy
The purpose of this study is to compare clinical, economical and quality of life (QOL) outcomes in patients living with HIV on zidovudine/stavudine regimen and tenofovir regimen. This study will be an unblinded randomized trial.
- Trial name
- NCT01694017
- Testing
- Tenofovir, Zidovudine
- Where
- India
- Volunteers
- 68 people
- Sponsor
- Tufts University
Physical Inactivity, Healthy
Supervised Center-based vs. Unsupervised Home-based Exercise Programs (PRO-Training)
The superiority of supervised center-based training programs compared with unsupervised home-based ones in older adults remains unclear, and no evidence exists on whether including a motivational component could moderate these…
- Conditions
- Physical Inactivity, Healthy, Older Adult
- Trial name
- PRO-Training (NCT05619250)
- Testing
- Unsupervised home-based exercise group without motivational intervention (UNSUP), Unsupervised home-based exercise group with motivational intervention (UNSUP+), Supervised center-based exercise group without motivational intervention (SUP)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Rheumatoid Arthritis
Optimal Management of Rheumatoid Arthritis Patients Requiring Biologic Therapy
That anti-TNF therapy and rituximab therapy are equally effective in treating patients with rheumatoid arthritis who meet the eligibility criteria for biologic therapy in the British Society for Rheumatology guidelines, and have…
- Trial name
- ORBIT (NCT01021735)
- Testing
- etanercept or adalimumab, Rituximab
- Where
- 8 sites in United Kingdom
- Volunteers
- 302 people
- Sponsor
- University of Glasgow
Caregiver Burden, Financial Stress
CONFIDENCE Financial Education for Caregivers
The purpose of this study is to determine how feasible it is to deliver an online course to reduce out-of-pocket costs of caregiving and reduce financial stress among Latino family caregivers to a family member living with…
- Conditions
- Caregiver Burden, Financial Stress, Dementia, Alzheimer Disease
- Trial name
- CONFIDENCE (NCT05292248)
- Testing
- Confidently Navigating Financial Decisions and Enhancing Financial Wellbeing in Dementia Caregiving
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Heart Failure, Congestive
Telemonitoring in Patients With Heart Failure
The purpose of this study is to investigate if telemonitoring results in a decrease in hospital admissions, with equal quality of care defined as mortality, quality of life and unplanned visits with caregivers.
- Trial name
- TEHAF2 (NCT00502255)
- Testing
- Health Buddy system, Telemonitoring in patients with heart failure
- Where
- 3 sites in Netherlands
- Volunteers
- 382 people
- Sponsor
- Maastricht University Medical Center
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