Clinical trials: Cost-Effectiveness
Healthy
Optimisation of Monitoring for Clinical Research Studies
OPTIMON will compare the efficacy and the cost of two monitoring strategies: one based on the classic standards of quality assurance, and the other one being a priori "optimized" on the main scientific and regulatory principles.
- Trial name
- OPTIMON (NCT00780091)
- Testing
- classical monitoring strategy, optimized monitoring strategy
- Where
- France
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Emotional Disorder, Anxiety Disorders
Unified Protocol for Treatment of Emotional Disorders in Brief Groups in Primary Care Services in Spain
The aim of this project is to contribute to the improvement of psychological care received in primary care (PC), through the study of the cost-effectiveness and acceptability of the Unified Protocol for the treatment of emotional…
- Conditions
- Emotional Disorder, Anxiety Disorders, Depressive Disorder
- Trial name
- NCT06547450
- Testing
- 5-session UP condition, 8-session UP condition
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
White Spot Lesion of Tooth
Clinical Outcomes, Cost-Effectiveness and Patient Satisfaction of Two Resin Infiltration Systems for The Management of White Spot Lesions
The aim of this study is to clinically evaluate and compare the color matching of white spot lesions (WSLs) following treatment with two resin infiltration systems: ICON resin infiltration and I-Mate resin infiltration.
- Trial name
- NCT07799350
- Testing
- light cured low viscosity resin infiltration
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Constipation
Comparison of TCM and Laxatives for Adults With Chronic Constipation
The purpose of the study is to compare the therapeutic efficacy, safety, cost-effectiveness and maintenance effect between Chinese herbal formula and lactulose on chronic constipation in long-term care.
- Trial name
- NCT00745147
- Testing
- Chinese herbal formula (CCH1), Duphalac
- Where
- Taiwan
- Volunteers
- 93 people
- Sponsor
- National Taiwan University Hospital
Dizziness
A Trial of Booklet Based Self Management of Dizziness
The investigators primary aim is to test whether or not provision of the self-help booklet teaching VR exercises, with up to one hour of telephone support from a vestibular therapist, will be more effective than routine care in…
- Trial name
- NCT00732797
- Testing
- Self-treatment booklet, Remote telephone support
- Where
- United Kingdom
- Volunteers
- 337 people
- Sponsor
- University of Southampton
Diabetes Mellitus, Type 2
Impact of Pharmacy Clinic on Diabetes Management
The Beaumont Hospital Royal Oak Outpatient Clinic (and other listed Beaumont recruiting locations) care for over 900 patients with diabetes.
- Trial name
- PharmaMD (NCT03377127)
- Testing
- Pharmacy Managed Diabetes Clinic (PMDC), Standard of Care (SOC)
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Corewell Health East
Depressive Disorder, Anxiety Disorder
Cost- Effectiveness Study of Brief Interventions for Mood and Anxiety Disorders
This study compares both clinical effectiveness and cost-effectiveness of a brief, intensified therapy and diagnostic method for patients with mood and/or anxiety disorders with Treatment As Usual (TAU) at five outpatient Mental…
- Trial name
- K&K (NCT01643642)
- Testing
- Cognitive behavioral treatment/farmacotherapy intervention, Treatment As Usual
- Where
- Netherlands
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Lung Cancer
Cost-effectiveness Evaluation of Robotic Surgery in the Removal of Lung Lesions in the ATS of Milan
The goal of this observational study is to compare cost-effectiveness of robotic surgery with open surgery and video-assisted thoracoscopy surgery (VATS) in adult patients, resident in the ATS of Milan area, operated for lung…
- Trial name
- NCT05674227
- Testing
- Robotic surgery, Video-assisted thoracoscopy, Open surgery
- Volunteers
- 5,400 people
- Sponsor
- Agenzia di Tutela della Salute della Città Metropolitana di Milano
Stroke, Hemiparesis
EEG Brain-Machine Interface Control of an Upper-Limb Robotic Exoskeleton for Robot-Assisted Rehabilitation After Stroke
The goal of this study is to develop a clinically feasible, low-cost, nonsurgical neurorobotic system for restoring function to motor-impaired stroke survivors that can be used at the clinic or at home.
- Trial name
- NeuroExo (NCT05374486)
- Testing
- NeuroExo co-robot neurorehabilitation system
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Houston
Hemophilia A
Extension at 10 Years of the: "Observational Study Evaluating Efficacy and Costs of Secondary Prophylaxis vs On-demand Therapy With Kogenate Bayer in Patients With Severe Haemophilia A."
Following the performance of the POTTER observational study, whose primary objective was to collect data on the benefits of secondary prophylaxis versus on demand treatment in terms of prevention of bleeding episodes, the present…
- Trial name
- POTTER 10 (NCT02581969)
- Testing
- Recombinant Factor VIII (Kogenate FS, BAY14-2222)
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Bayer
Perinatal Depression
Clinical and Cost-effectiveness of an Online Self-help Intervention and a Face-to-face Intervention Versus Usual Care in Mothers at Moderate Risk for Perinatal Depression
The perinatal period (pregnancy and the first postnatal year) (O'Hara \& Wisner, 2014) involves important changes and considerable challenges for parents (Milgrom \& Gemmill, 2015).
- Trial name
- MaMHI (NCT07027761)
- Testing
- Online self-help, Maternal Mental Health Intervention (MaMHI), Usual Care
- Where
- Belgium
- Volunteers
- 210 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ulnar Collateral Ligament Sprain, Skier's Thumb
RCT on Nonoperative Versus Operative Treatment for Acute Complete tearS of the Ulnar Collateral ligAment of the Thumb
A complete rupture of the ulnar collateral ligament (UCL) of the thumb must heal in order to regain proper function of the thumb. Guidelines recommend surgery for complete UCL ruptures, including Stener lesions.
- Trial name
- MUSCAT (NCT05291260)
- Testing
- Cast immobilization, Surgical treatment
- Where
- Netherlands
- Volunteers
- 126 people
- Sponsor
- Diakonessenhuis, Utrecht
Prostate Cancer
Identifying the Best Follow up Approach for People Who Have Had Treatment to Cure Newly Diagnosed Prostate Cancer
Over 20,000 patients a year in the UK get surgery or radiotherapy to cure their prostate cancer. These men then undergo regular check-ups to manage potential side effects and see if cancer recurs so it can be treated quickly.
- Trial name
- FOLLOW-UP (NCT07264088)
- Testing
- Hospital based follow up, Primary care based follow up, Planned shared care follow up
- Where
- United Kingdom
- Volunteers
- 100,000 people
- Sponsor
- Imperial College London
Mandible Fracture
Arch Bars vs. IMF (Intermaxillary Fixation) Screws: Cost Effectiveness Based on Time Duration of Device Placement.
Determining the cost effectiveness, based on the time duration of application, of two methods of wiring the jaws together during surgery to repair mandible fractures.
- Trial name
- NCT01876979
- Testing
- IMF Screws, Erich Arch Bars
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Christiana Care Health Services
Thromboses, Deep Vein, Surgery--Complications
Thromboprophylaxis in Patients Undergoing Orthopedic Surgeries; Comparison Between Rivaroxaban and Enoxaparin
The main objective is to reduce the incidence of venous thromboembolism (VTE) in orthopedic postoperative patients based on the potential benefit of using rivaroxaban as a monotherapy.
- Trial name
- NCT03299296
- Testing
- Rivaroxaban 10 Milligrams, Enoxaparin 40 Milligrams/0.4 Milliliters Prefilled Syringe
- Volunteers
- 100 people
- Sponsor
- Ahmed AbdelMoneim Hassan Ali
Pregnancy
Home Based Life Saving Skills Training in a Rural Area in Tanzania
Background The maternal mortality ratio in Tanzania has been persistently high for ten years with no signs of the ratio going down.The Tanzania Demographic and Health Survey (TDHS) of 1999 and 2005 estimate the maternal mortality…
- Trial name
- HBLSS (NCT01192646)
- Testing
- HBLSS
- Where
- Tanzania
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Muhimbili University of Health and Allied Sciences
HIV
Impact on Linkage to HIV Care With Point of Care CD4 Testing and Home-based HIV Testing in Kenya
Randomised Controlled Trial to Assess Accuracy, Feasibility, Acceptability, Cost Effectiveness and Impact of Point of Care CD4 Testing on HIV Diagnosis, Linkage to Care and Time to Antiretroviral Therapy Initiation among HIV…
- Trial name
- CD4-POC (NCT02515149)
- Testing
- Point of care CD4 device (Alere PIMA)
- Where
- Kenya
- Volunteers
- 770 people
- Sponsor
- Centers for Disease Control and Prevention
Burns
Impact of a Clinical Decision Algorithm on Length of Hospital Stay and Costs of Care of Burned Patients
Reliable and valid assessment of burn wound depth or healing potential is essential to treatment decision-making, to provide a prognosis, and to compare studies evaluating different treatment modalities.
- Trial name
- NCT03876340
- Testing
- Treatment algorithm, Current treatment
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
Depression
Cognitive Behavioral Therapy (REBT) Evaluation for Depression at Primary Care.
Background: Rational Emotional Behavioral Therapy (REBT) applied by the Primary Health Care (PC) Social Worker reduces psychotropic drug use and overcrowding at medical appointments.
- Trial name
- NCT05235789
- Testing
- Rational-Emotive-Behavioral Therapy, Control Group usual care
- Where
- Spain
- Volunteers
- 900 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Knee Osteoarthritis
Evaluation of an Educational Program Associated With Exercises (EDEX) Before Total Knee Arthroplasty
The purpose of this study is to determine whether a standardized education and exercise program proposed before a total knee replacement for knee osteoarthritis is effective in functional recovery after surgery.
- Trial name
- EDEX (NCT01671917)
- Testing
- Educational and exercise program, Usual care
- Where
- France
- Volunteers
- 262 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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