Clinical trials: Cost-Effectiveness
Depression
Behavioral Medicine Intervention With Depressed Patients in a Community Health Center Setting
The linkage between the Massachusetts General Hospital (MGH)-Community Health Associates and the MGH-Benson Henry Institute for Mind-Body Medicine began in order to address the concern of providing affordable, easily accessible…
- Trial name
- NCT01330420
- Testing
- Relaxation Response Resiliency Program for Depression
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Physical Activity, Exercise Training
Home-based Exercise and Physical Activity Intervention After Kidney Transplantation: Impact of Exercise Intensity
This multicentre two-phased RCT aims to evaluate implementation potential, cost-effectiveness, effectiveness, and the role of exercise intensity of a home-based exercise and physical activity intervention to improve de novo…
- Conditions
- Physical Activity, Exercise Training, Kidney Transplantation, Physical Fitness
- Trial name
- PHOENIX-Kidney (NCT06260579)
- Testing
- Exercise/physical activity
- Where
- 2 sites in Belgium
- Volunteers
- 147 people
- Sponsor
- KU Leuven
Prediabetic State & High Risk Individuals on the Basis of Diabetes Risk Score
(Pakistan Diabetes Prevention Program PDPP)
The Karachi-based Pakistan Diabetes Prevention Study aims to address key issues in the prevention of type 2 diabetes. Approximately 20,000 people From four communities will be screened for diabetes risk factors using a…
- Trial name
- PDPP (NCT01530165)
- Testing
- Life style intervention
- Where
- Pakistan
- Volunteers
- 1,564 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Morbidity of Hysterectomy
Finhyst 2006: Study on Morbidity of Hysterectomies in Finland
The purpose of this study is to analyze prospectively all hysterectomies performed in Finland for benign indications including all 46 public hospitals performing hysterectomies and also 7 private clinics.
- Trial name
- Finhyst 2006 (NCT00744172)
- Testing
- laparoscopy, vaginal, abdominal
- Where
- Finland
- Volunteers
- 5,279 people, healthy volunteers welcome
- Sponsor
- Society for Gynecological Surgery in Finland
Adherence, Medication
Effectiveness and Cost-effectiveness of the Initial Medication Adherence Intervention
The purpose of this study is to assess the effectiveness and the cost-effectiveness of the Initial Medication Adherence (IMA) Intervention.
- Trial name
- IMA-cRCT (NCT05026775)
- Testing
- Initial Medication Adherence (IMA), Usual care
- Where
- 24 sites in Spain
- Volunteers
- 4,153 people
- Sponsor
- Fundació Sant Joan de Déu
Mouth, Edentulous
A Cost-effectiveness Analysis of the Single-implant Mandibular Overdenture Treatment
The aim of this study is to assess the cost-effectiveness of the mandibular overdenture retained by a single implant. The study hypothesis is that SIMO is more effective but more costly than the conventional denture, though this…
- Trial name
- SIMOECON (NCT02710357)
- Testing
- Mandibular Overdenture, Mandibular complete denture
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Sexually Transmitted Infection, HIV/AIDS
Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes (Philani Ndiphile)
This study aims to evaluate different screening strategies to decrease the burden of Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV) among pregnant women, and reduce adverse birth outcomes.
- Conditions
- Sexually Transmitted Infection, HIV/AIDS, Cost-effectiveness, Birth Outcomes
- Trial name
- NCT04446611
- Testing
- First antenatal care + test-of-cure, First antenatal care + week 30-34 gestation (no test-of-cure)
- Where
- South Africa
- Volunteers
- 2,247 people, healthy volunteers welcome
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Cardiogenic Shock
Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock
Cardiogenic shock (CGS) affects up to 10% of patients suffering acute coronary syndrome. It has a 30 day mortality of 45-50%. No pharmacological nor intervention/device trials have had any impact on this mortality in the last 20…
- Trial name
- EUROSHOCK (NCT03813134)
- Testing
- Percutaneous coronary intervention (PCI), Pharmacological Support, VA-ECMO
- Where
- 47 sites in Austria, Belgium and 6 more
- Volunteers
- 428 people
- Sponsor
- University of Leicester
DGBI, Depression/Anxiety
Evaluation of an Online ACT and Compassion-based Intervention for Disorders of Gut-Brain Interaction
The goal of this clinical trial is to assess the efficacy and cost-effectiveness of the iACTforDGBI intervention among adults with Disorders of Gut-Brain Interaction (DGBI) and psychological distress.
- Trial name
- iACTforDGBI (NCT07521709)
- Testing
- Acceptance and Commitment Therapy with explicit self-compassion training, Education
- Where
- Sweden
- Sponsor
- Örebro University, Sweden
Emphysema
Lung Volume Reduction Coil Treatment in Emphysema.
BACKGROUND: Medical therapeutic options for the treatment of emphysema remain limited. Lung volume reduction surgery is infrequently used because of its high morbi-mortality.
- Trial name
- STICREVOLENS (NCT01822795)
- Testing
- Lung volume reduction coïl treatment, Regular medical treatment
- Where
- 9 sites in France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Hypertensive Disorders of Pregnancy
Pregnancy Salt Substitution Trial for Hypertensive Disorders of Pregnancy Prevention (PREG-Salt)
The PREG-Salt study is to evaluate the effect, safety and cost-effectiveness of low-sodium salt in reducing blood pressure and preventing hypertensive disorders in pregnant women at high risk in China.
- Trial name
- PREG-Salt (NCT07294807)
- Testing
- Potassium-enriched salt substitute, Usual salt
- Where
- 110 sites in China
- Volunteers
- 3,200 people
- Sponsor
- Peking University
Cholera
Introduction of Cholera Vaccine in Bangladesh
The purpose of this study is to conduct and evaluate the feasibility and effectiveness of a mass cholera vaccination program to reduce diarrhea due to Vibrio cholerae in a high incidence urban area.
- Trial name
- ICVB (NCT01339845)
- Testing
- ShanChol, Vaccine and behaviour
- Where
- Bangladesh
- Volunteers
- 240,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cancer-related Cognitive Impairment
Electroacupuncture for Cognitive Toxicity in Cancer Survivors: Assessing Implementation, Cost, and Effectiveness for Integration
The goal of this clinical trial is to evaluate the clinical effectiveness and understand the biological mechanisms of electroacupuncture (EA) in reducing cognitive toxicity among cancer survivors.
- Trial name
- EAST-ALIGN (NCT07583979)
- Testing
- True electroacupuncture
- Where
- Singapore
- Volunteers
- 168 people
- Sponsor
- National Cancer Centre, Singapore
Orthodontic Relapse, Retention in Orthodontic
Effectiveness, Patient Acceptance, and Cost Estimation of 3D-printed Retainer Compared to Hawley Retainer in Expansion Case: a Randomized Controlled Trial
Expansion of the arches is generally considered highly unstable and prone to relapse regardless of the type of expansion. Retention appliances play a vital role in preserving these changes.
- Trial name
- NCT07659041
- Testing
- 3D printed retainer, Hawley retainer
- Where
- 3 sites in Malaysia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Chronic Disease, Quality of Life
Electronic Patient Reported Outcome (ePRO) Mobile Application Pragmatic Trial
Canadian and international health care systems require solutions on how to address the needs of a relatively small population that take up a large portion of health care resources.
- Trial name
- NCT02917954
- Testing
- ePRO Tool Intervention
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Chest Pain
Impact on Management of the HEART Risk Score in Chest Pain Patients
Aim of this study is to quantify the impact of the use of the HEART risk score on patient outcome and on costs in patients with chest pain presenting at the emergency room, as compared to not using the score.
- Trial name
- HEART-Impact (NCT01756846)
- Testing
- usual care, use of HEART risk score
- Where
- 9 sites in Netherlands
- Volunteers
- 3,666 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Female Reproductive Problem, Infertility
Use of Corifolitropin Alfa in Oocyte Donors
The purpose of this study is to determine if corifollitropin alfa (long-term gonadotropin administration) is effective in a controlled ovarian stimulation protocol in oocyte donors compared to daily gonadotropin administration…
- Trial name
- NCT02213627
- Testing
- Corifollitropin alfa, Recombinant FSH, HP-hMG
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Pneumothorax
A Prospective Randomised Study of Efficacy, Safety and Costs of Talc Pleurodesis Under Medical Thoracoscopy and Pleurodesis Under Video-assisted Thoracoscopy Surgery for Recurrent Primary Spontaneous Pneumothorax
Treatment of recurrent primary spontaneous pneumothorax remains controversial and many therapeutic options exist. The aim of this study is to compare pleural symphysis by talc poudrage during medical thoracoscopy and surgical…
- Trial name
- NCT00767962
- Testing
- talc pleurodesis under medical thoracoscopy, pleurodesis under video-assisted thoracoscopy surgery
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Diabetes Mellitus, Type 2
Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholesterol Control in T2DM
To evaluate the effect of the combination of chromium picolinate (600 μg Cr) + biotin (2 mg) versus placebo on glycosylated hemoglobin (HbA1c), lipid profiles (Total-C, HDL-C, LDL-C, TGs, TG/HDL ratio, etc), and pharmacoeconomic…
- Trial name
- NCT00289354
- Testing
- Chromium Picolinate (600 mcg Cr) + biotin (2 mg)
- Volunteers
- 600 people
- Sponsor
- Nutrition 21, Inc.
Recurrent Upper and Lower Respiratory Tract Infections (RTIs)
Prevention of Respiratory Infections and MAnagement Among Children (PRIMAKid)
The PRIMAKid trial is a general practice based double-blind randomized placebo-controlled trial on the effectiveness and costs of combined influenza and pneumococcal vaccination in pre-school children with recurrent respiratory…
- Trial name
- NCT00161122
- Testing
- trivalent inactivated influenza vaccine, combined heptavalent pneumococcal conjugate vaccine and trivalent inactivated influenza vaccine
- Where
- Netherlands
- Volunteers
- 660 people
- Sponsor
- UMC Utrecht
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