Clinical trials: Cost-effectiveness
Post-operative Pain
Efficacy of IV Acetaminophen for Pain Management
The investigators' goal in this planned prospective, randomized, patient blinded study is to compare our standard of care as the control group to an experimental group in which patients receive preemptive IV acetaminophen dosing…
- Trial name
- NCT02028715
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Aultman Health Foundation
Remote Consultation, Teleconsultation, Remote Consultation, Video
Evaluation of Videoconferencing Versus Telephone Genetic Counseling
Genetic counseling has benefits for individuals and their family members in their health care decision-making. Provision of genetic counseling has been deemed standard of care by several medical organizations and incorporated…
- Trial name
- EVTGC (NCT02108977)
- Testing
- Videoconferencing Genetic Consultation, Teleconferencing Genetic Consultation
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Hypercholesterolemia
Cholesterol Medication Packaging Study
The purpose of the overall study is to improve medication use rates among veterans by looking at the risk factors of low-density lipoprotein cholesterol (LDL).
- Trial name
- MWV_CAPS (NCT01744977)
- Testing
- packaging
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Durham VA Medical Center
Diabetic Macular Edema
Safety, Efficacy and Cost-efficacy of Ranibizumab (Monotherapy or Combination With Laser) in the Treatment of Diabetic Macular Edema (DME)
To evaluate, specifically within the Canadian medical environment, the efficacy, safety and cost-efficacy of ranibizumab administered either as combination therapy (ranibizumab plus laser photocoagulation), or as monotherapy in…
- Trial name
- RESPOND (NCT01135914)
- Testing
- ranibizumab, Laser
- Where
- 20 sites in Canada
- Volunteers
- 241 people
- Sponsor
- Novartis Pharmaceuticals
Depression
Behavioral Medicine Intervention With Depressed Patients in a Community Health Center Setting
The linkage between the Massachusetts General Hospital (MGH)-Community Health Associates and the MGH-Benson Henry Institute for Mind-Body Medicine began in order to address the concern of providing affordable, easily accessible…
- Trial name
- NCT01330420
- Testing
- Relaxation Response Resiliency Program for Depression
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Myocardial Infarction, Coronary Artery Disease
Myocardial Infarction, COmbined-device, Recovery Enhancement Study
Unplanned readmissions after hospitalization for acute myocardial infarction (AMI) are among the leading causes of preventable morbidity, mortality, and healthcare costs.
- Conditions
- Acute Myocardial Infarction, Coronary Artery Disease, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- MiCORE (NCT03760796)
- Testing
- Corrie Health Digital Platform
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Staphylococcal Infections
Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent Methicillin-resistant Staphylococcus Aureus & Other Hospital Infections
This pilot study in our medical intensive care unit will evaluate the clinical and cost-effectiveness of an active surveillance program for methicillin-resistant Staphylococcus aureus (MRSA), compared to routine daily bathing…
- Trial name
- NCT00779246
- Testing
- Nasal swabs for MRSA culture, Chlorhexidine gluconate, Contact isolation
- Where
- United States
- Volunteers
- 1,518 people
- Sponsor
- Christiana Care Health Services
Obsessive-compulsive Disorder
Stepped Care for Treating Obsessive-Compulsive Disorder
This study will determine the effectiveness and cost-effectiveness of a stepped-care treatment program for people with obsessive-compulsive disorder.
- Trial name
- NCT00316355
- Testing
- Traditional CBT, Stepped-Care CBT
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Hartford Hospital
Human Immunodeficiency Virus
Package of Resources for Assisted Contact Tracing: Implementation, Costs, and Effectiveness
Having health workers assist HIV-infected persons with the recruitment and testing of their sexual contacts and biological children is an effective and efficient way of identifying additional HIV-infected persons in need of HIV…
- Trial name
- PRACTICE (NCT05343390)
- Testing
- Enhanced implementation package, Standard implementation package
- Where
- 33 sites in Malawi
- Volunteers
- 841 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Low Back Pain
Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation
Lumbar zygapophysial (facet) joint pain is a common cause of low back pain. Radiofrequency (RF) denervation is an effective and low risk treatment of chronic low back pain of suspected facet joint etiology.
- Trial name
- NCT00484159
- Testing
- Radiofrequency denervation of medial branches, 0.5% bupivacaine, 2% lidocaine
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Johns Hopkins University
Chronic Disease, Multi-morbidity
Minnesota Care Coordination Effectiveness Study
Medical care has improved greatly over the past 50 years. Treatments for most medical conditions can help us lead longer and healthier lives, but there are still problems.
- Conditions
- Chronic Disease, Multi-morbidity, Care Coordination
- Trial name
- MNCARES (NCT04957979)
- Testing
- Nursing/Medical Model of Care Coordination, Medical/Social Model of Care Coordination
- Where
- 3 sites in United States
- Volunteers
- 25,507 people
- Sponsor
- HealthPartners Institute
Childhood Asthma
Supervised Asthma Medication in Schools (SAMS)
The investigators hypothesize that school-based, direct supervision of daily controller therapy will result in more effective asthma control, as assessed by the Asthma Control Questionnaire than usual care.
- Trial name
- SAMS (NCT01997463)
- Testing
- Supervised asthma therapy in schools
- Where
- United States
- Volunteers
- 442 people
- Sponsor
- University of Arizona
HIV-1-infection
INTERVAL: Varying Intervals of ART to Improve Outcomes in HIV
This is an unblinded cluster-randomized study to evaluate the effectiveness of two strategies for scripting/dispensing of antiretroviral therapy (ART) on retention, virologic suppression, and cost compared to the standard of…
- Trial name
- INTERVAL (NCT03101592)
- Testing
- Three-month ART dispensing, Six-month ART dispensing
- Where
- 2 sites in Malawi, Zambia
- Volunteers
- 9,118 people
- Sponsor
- University of California, Los Angeles
Alcohol Drinking, Veterans
Cost Effectiveness of Combined Contingency Management and Cognitive Behavioral Therapy for Alcohol Use Disorder
Alcohol contributes to 88,000 deaths and costs an estimated $223 billion annually in the United States. Alcohol use disorder (AUD) is highly prevalent in veterans.
- Trial name
- NCT03987581
- Testing
- Cognitive Behavioral Therapy (CBT), Mobile Contingency Management (mCM), Long-term incentive
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Duke University
Mandible Fracture
Arch Bars vs. IMF (Intermaxillary Fixation) Screws: Cost Effectiveness Based on Time Duration of Device Placement.
Determining the cost effectiveness, based on the time duration of application, of two methods of wiring the jaws together during surgery to repair mandible fractures.
- Trial name
- NCT01876979
- Testing
- IMF Screws, Erich Arch Bars
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Christiana Care Health Services
Venous Leg Ulcer, Mixed Leg Ulcer
Leg Ulcers Standards of Care Enhancement
Multi-center, prospective,randomized controlled study on the speed of healing, life quality and cost-effectiveness of the treatment with a blue light medical device (EmoLED) versus existing Standards Of Care (SOC) for patients…
- Trial name
- LUCE (NCT04689009)
- Testing
- EmoLED, current Standards Of Care
- Where
- 5 sites in Italy
- Volunteers
- 83 people
- Sponsor
- Emoled
Chest Pain, Acute Coronary Syndrome
Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS)
This multi-center, randomized, controlled trial conducted in Emergency Departments (ED) compares computed tomography (CT) coronary angiography with the traditional approach (usual care) for low- to intermediate-risk chest pain…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT00933400
- Testing
- CT Coronary Angiography (CTCA), Traditional Strategy
- Where
- 5 sites in United States
- Volunteers
- 1,392 people
- Sponsor
- American College of Radiology
Knee Osteoarthritis, Hip Osteoarthritis
Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties
Barbed sutures offer several potential advantages in layered wound closure of hip and knee replacement surgeries. It use is gaining increased acceptance across many of the other surgical disciplines at this time.
- Trial name
- NCT00834483
- Testing
- Knotless suture for wound closure, Layered traditional wound closure (monocryl)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
HIV Infections
Use of HIV Self-Test Kits to Increase Identification of HIV-Infected Individuals and Their Partners
This study comprises two trials to evaluate the feasibility and cost-effectiveness of HIV self-testing strategies compared to standard of care among clients in outpatient departments (OPD; Aim 1) and the sexual partners of…
- Trial name
- NCT03271307
- Testing
- Optimized PITC, Facility HIVST, Index HIVST
- Where
- Malawi
- Volunteers
- 6,369 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV/AIDS
Suubi4Her: Combination Intervention for Adolescent Girls Transitioning Into Adulthood in Uganda
This study examines the impact and cost associated with Suubi4Her, an innovative combination intervention that aims to prevent HIV risk behaviors among 15-17 year-old girls living in communities heavily affected by poverty and…
- Trial name
- NCT03307226
- Testing
- Youth Development Accounts (YDA), YDA + Multiple Family Groups (MFG)
- Where
- 2 sites in Uganda
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine