Clinical trials: Cough
Diphtheria, Tetanus
Study of DAPTACEL® Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™
Objectives: To present the rates of adverse reactions after a dose of DAPTACEL® vaccine administered to children 4 to 6 years of age who have previously received four doses of PENTACEL™ vaccine.
- Conditions
- Diphtheria, Tetanus, Pertussis, Polio
- Trial name
- NCT00802867
- Testing
- Diphtheria and Tetanus Toxoids and Acellular Pertussis (DAPTACEL®)
- Where
- 19 sites in United States
- Volunteers
- 989 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Diphtheria, Tetanus
A Study of DTaP-IPV-Hep B-PRP-T Vaccine Given With Prevenar™ and Rotarix™ in Healthy Latin American Infants
The purpose of this study is to generate immunogenicity and safety data of an investigational hexavalent DTaP-IPV-Hep B-PRP-T vaccine compared to a control vaccine, Infanrix hexa™ when given along with Prevenar™ and Rotarix™…
- Conditions
- Diphtheria, Tetanus, Whooping Cough, Hepatitis B
- Trial name
- NCT01177722
- Testing
- DTaP-IPV-Hep B-PRP-T Vaccine, DTaP-Hep B-IPV vaccine
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 1,375 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Acute Disease, Acute Hospitalization
Efficiency of the "Medidux" Smartphone App for Demission Management in Patients Medicated in Acute Admission Unit (AAU)
The goal of this clinical trial is to evaluate whether the use of the medidux™ smartphone app can optimize post-discharge management for patients admitted to Acute Admission Units (AAU) with non-urgent health complaints.
- Conditions
- Acute Disease, Acute Hospitalization, Coughing, Back Pain
- Trial name
- EffiDux (NCT06655337)
- Testing
- Smartphone Application for Post-Discharge Symptom Monitoring
- Where
- Switzerland
- Volunteers
- 417 people
- Sponsor
- Mobile Health AG
Cough
Comparison of SCH 486757 to Codeine and Placebo in Subjects With Persistent Postviral Cough (Study P03069AM2)(COMPLETED)
This randomized, multicenter, parallel-group, double-blind, double-dummy, placebo- and active-controlled study will evaluate the efficacy and safety of SCH 486757 in subjects with persistent cough resulting from a recent viral…
- Trial name
- NCT00230230
- Testing
- SCH 486757
- Volunteers
- 91 people
- Sponsor
- Merck Sharp & Dohme LLC
COVID-19
Efficiency of the Imaging Strategy for the Management of Suspected Covid-19
Emergency departments have been placed at the heart of the patient triage strategy during the COVID-19 epidemic. In the absence of scientific knowledge on the most efficient strategy to put in place in emergency structures, the…
- Trial name
- EFFI-COVID-19 (NCT05077228)
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Strasbourg, France
Pulmonary Disease, Chronic Obstructive
Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath
The study does not involve testing of a drug (no treatment intervention). The study will will use spirometry (breathing tests) in subjects of 40 years of age and older with a history of cigarette smoking with chronic bronchitis…
- Trial name
- NCT00442468
- Testing
- Non-interventional study.
- Where
- 47 sites in United States
- Volunteers
- 1,283 people
- Sponsor
- GlaxoSmithKline
Sleep, Pollution; Exposure
Investigating the Effect of Daily CARDIO® Capsules Supplementation on Improved Sleep in Healthy, Urban-Dwelling Adults
This study aims to explore the impact of supplementation with CARDIO® whole salmon oil capsules on healthy adult participants with sleep disruption related to particulate matter pollution.
- Conditions
- Sleep, Pollution; Exposure, Cough
- Trial name
- NCT06768970
- Testing
- CARDIO® salmon oil
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Hofseth Biocare ASA
Asthma Chronic, Cough
ToAST:Investigating the Effect of Bronchial Thermoplasty on Cough in Patients With Severe Asthma
ToAST study is a pilot study aiming to establish the safety profile of using inhaled capsaicin challenge in patients with severe asthma.
- Trial name
- ToAST (NCT03281941)
- Testing
- Inhaled capsaicin cough challenge
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- National Health Service, United Kingdom
Bordetella Pertussis, Whooping Cough
Impact of Bacterial Expression and Immune Response in the Severity of Pertussis
The resurgence of pertussis is associated with an evolutionary mechanism under the pressure of current acellular vaccines, with a possible impact on vaccine effectiveness and disease expression.
- Trial name
- PERT-SEVEREII (NCT05897879)
- Testing
- Nasopharyngeal swab, Blood samples
- Where
- 14 sites in France
- Volunteers
- 210 people
- Sponsor
- Institut Pasteur
Diphtheria, Tetanus
Lot Consistency Study of DTaP-IPV-HB-PRP~T Vaccine Administered at 2-4-6 Months of Age in Healthy Infants
The purpose of this trial is to clinically confirm that the manufacturing process of the final bulk products of the investigational DTaP-IPV-HB-PRP~T vaccine is consistent.
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT00404651
- Testing
- DTaP-IPV-HB-PRP~T vaccine, DTaP-HBV-IPV vaccine
- Where
- 6 sites in Mexico
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Pertussis
TDAP Safety in Pregnant Women
The purpose of this observational study is to evaluate the safety of Tetanus Toxoid Reduced Diphtheria, Toxoid, and Acelluar Pertussis Vaccine (Tdap) in pregnant women at ≥ 20 weeks 0 days gestation receiving Tdap as part of…
- Trial name
- Tdap (NCT02209623)
- Testing
- TDAP
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cough
First-in-Human Study to Investigate the Safety and Tolerability and Pharmacokinetics of HS-10383
This is a first-in-human study that will investigate the safety, tolerability and pharmacokinetics of ascending single doses of HS-10383 using a randomized, double blind, placebo controlled, single center study design.
- Trial name
- NCT05429723
- Testing
- HS-10383
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Cough
Clinical Validation of the Hyfe Cough Monitoring System
This is a multicenter observational study and will include individuals with a variety of cough related conditions including but not limited to refractory chronic cough, Chronic Obstructive Pulmonary Disease (COPD) and…
- Trial name
- NCT05723159
- Testing
- Clinical Validation of the Hyfe Cough Monitoring System
- Where
- 3 sites in United States, Spain
- Volunteers
- 21 people
- Sponsor
- Hyfe Inc
Diphtheria, Pertussis
Study of PR5I, a Pediatric Combination Vaccine With Enhanced Hepatitis B Component Given Concomitantly With Prevnar®
PR5I, a hexavalent pediatric combination vaccine is being developed to reduce the number of injections during the first 2 years of life while providing a complete course of immunization against infection caused by H.
- Conditions
- Diphtheria, Pertussis, Polio, Hepatitis B
- Trial name
- NCT00362427
- Testing
- Hybrid 5 component DTaP, Vero IPV, Hep B and PRP-OMPC
- Where
- 8 sites in Canada
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Obesity
Optimising Protection for Pregnant Women and Infants With Maternal Vaccination
This study has been designed to investigate if: 1. BMI affects the immunogenicity of influenza and pertussis vaccines given during pregnancy. 2.
- Trial name
- OPTIWIN (NCT03457194)
- Testing
- Quadrivalent Influenza Vaccine, DTP Vaccine (Multiple Actives)
- Where
- Australia
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Women's and Children's Hospital, Australia
Asthma, Cough Variant Asthma
Optimal Type of Inhaler in Cough Variant- or Cough Predominant Asthma
Asthma management is based on inhaled therapy, mainly on inhaled glucocorticosteroids (ICS). The efficacy of inhaled therapy depends on type of inhaler and proper inhalation skills.
- Trial name
- NCT04203472
- Testing
- Budesonid or budesonide/fomoterol administered by DPI, Budesonid or budesonide/fomoterol administered by MDI
- Where
- Poland
- Volunteers
- 22 people
- Sponsor
- Medical University of Warsaw
Pulmonary Fibrosis
Pomalidomide for Cough in Patients With Idiopathic Pulmonary Fibrosis
The purpose of this study is to determine the safety and efficacy of pomalidomide over a 12 week duration in the treatment of chronic cough in patients with IPF as measured by a Cough Symptom Diary, Visual Analogue Scale for…
- Trial name
- NCT01135199
- Testing
- pomalidomide (CC-4047
- Where
- United States
- Sponsor
- Stanford University
Lung Cancer (Diagnosis), Acupressure
Acupressure for Cough in Lung Cancer Survivors
The goal of this randomized controlled trial is to examine the effect of an acupressure intervention in alleviating cough and reducing co-occurring symptoms (dyspnea, cough, and fatigue) in patients with lung cancer.
- Conditions
- Lung Cancer (Diagnosis), Acupressure, Coughing, Symptom Cluster
- Trial name
- NCT07315672
- Testing
- acupressure, Education
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
Cough Suppression, Thyroidectomy
Effects of Dexmedetomidine Combined With Lidocaine Topical Administration on Cough Reflex During Extubation in Thyroidectomy Patient.
Study Hypothesis: The combination of dexmedetomidine and lidocaine administered as laryngopharyngeal topical spray provides superior suppression of extubation cough reflex compared to lidocaine alone or placebo, without…
- Trial name
- NCT07832214
- Testing
- · Dex-Lido solution: Dexmedetomidine 100 μg/mL (concentration) was diluted with 2% lidocaine to achieve final concentration of dexmedetomidine 1 μg/kg in 5 mL total volume, · Lido solution: 2% lidocaine, 5 mL, · Control solution: 0.9% normal saline, 5 mL
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
COVID19
Evaluation of the AudibleHealth Dx AI/ML-Based Dx SaMD Using FCV-SDS in the Diagnosis of COVID-19 Illness
The AudibleHealth Dx is a diagnostic software as a medical device (Dx SaMD) consisting of an ensemble of software subroutines that interacts with a proprietary database of Signal Data Signatures (SDS), using Artificial…
- Trial name
- NCT05175690
- Testing
- Diagnostic Software as Medical Device
- Where
- United States
- Volunteers
- 1,126 people, healthy volunteers welcome
- Sponsor
- AudibleHealth AI, Inc.