Clinical trials: Cough Hypersensitivity Syndrome
Cough, Refractory Chronic Cough
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
The FORTITUDE trial will provide head-to-head evidence on the benefits and harms of two commonly prescribed neuromodulators (low-dose morphine and pregabalin), the effectiveness of a virtual cough control therapy, exploratory…
- Conditions
- Cough, Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity Syndrome
- Trial name
- FORTITUDE (NCT07288528)
- Testing
- Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin
- Where
- 5 sites in Canada
- Volunteers
- 124 people
- Sponsor
- McMaster University
Cough
Influence on Cough and Airway Symptoms by Oral Capsaicin
Study objectives To establish whether an oral intake of Capsicum oleoresin; capsaicinoids expressed as 0.4 mg capsaicin (C18H27N03; Mw: 305.4) in each capsule (from chili extract) can desensitise the cough reflex and improve…
- Trial name
- NCT04125563
- Testing
- Capsicum Oleoresin
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Vastra Gotaland Region
Chronic Cough (CC), Refractory Chronic Cough
Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic Cough
This study is testing new ways to help people who have chronic cough that has not improved with typical treatments. One approach is called behavioral cough suppression (BCS) therapy, which teaches people techniques to stop…
- Conditions
- Chronic Cough (CC), Refractory Chronic Cough, Unexplained Chronic Cough
- Trial name
- CoughLESS (NCT06960759)
- Testing
- BCS+inactive, BCS+active
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- University of Montana
Postoperative Cough, Cough Hypersensitivity Syndrome
Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough
Numerous current studies have indicated that transecting the pulmonary plexus nerve as a routine step in radical lung cancer surgery is an independent risk factor for cough hypersensitivity (CH).
- Trial name
- ENERGY-COUGH (NCT07524712)
- Testing
- Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Tongji Hospital
Chronic Cough
Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough
This study is a prospective, single-center, single-arm pilot trial. The primary research question is whether brief, breath control-focused Acceptance and Commitment Therapy (ACT) is feasible, acceptable, and safe in adults with…
- Trial name
- FAST-COUGH (NCT07566117)
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Cough (CC), Asthma
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough.
- Trial name
- NCT07085975
- Testing
- Adenosine 5'-triphosphate
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cough
Cough Desensitization Therapy for Cough Hypersensitivity Syndrome
The purpose of this study is to investigate a modified behavioral treatment for chronic cough due to cough hypersensitivity syndrome (CHS).
- Trial name
- NCT04256733
- Testing
- Supra-threshold and progressive doses of diluted capsaicin via a Koko Digidoser nebulizer, Sub-threshold doses of diluted capsiacin via a KoKo Digidoser nebulizer
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Montana
Cough
An Investigation Into the Mechanism of Inhalation Cough Challenge
Despite its commonplace use in respiratory medicine the mechanism whereby inhalation challenge with a variety of mild acid aerosols produces a dose related and predictable cough is unknown.
- Trial name
- NCT02039999
- Testing
- Nebulised citric acid in serial dilutions, Nebulised ATP solution in serial dilutions, Nebulised TRPA1 agonist solution in serial dilutions
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust