Clinical trials: Covid-19 Patients
COVID-19, Outcome, Fatal
Critically Ill ICU Patients Under Casirivimab- and/or Tocilizumab Application
In a retrospective observational study, critically ill COVID-19 patients admitted to the ICU with the CoV-2 delta-variant between august 2021 and february 2022 were evaluated (ethics application nr.
- Conditions
- COVID-19, Outcome, Fatal, Tocilizumab, Interleukin 6
- Trial name
- CasiTocCOVID (NCT06233357)
- Testing
- treated without (N), with casirivimab / imdevimab (C) or tocilizumab (T), solely, or in combination of both (C + T)
- Where
- Germany
- Volunteers
- 95 people
- Sponsor
- University of Ulm
Colorectal Neoplasms Malignant
Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread…
- Trial name
- COVID-CRC (NCT04712292)
- Testing
- Surgical procedure for confirmed or suspected colorectal cancer
- Where
- 45 sites in Italy
- Volunteers
- 15,000 people
- Sponsor
- University of Bologna
Ischemic Stroke, Covid 19
Endovascular Thrombectomy in COVID-19 Infected Patients
About 5% of COVID-19 patients may present symptoms related to acute ischemic stroke (AIS). Treatment-management and outcomes related to mechanical thrombectomy (MT) for COVID-19 infected patients harboring large vessel occlusion…
- Trial name
- ET-COVID-19 (NCT04406090)
- Testing
- Mechanical Trombectomy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
COVID-19
A Randomized Controlled Trial Assessing the Efficacy of Lianhua Qingwen as an Adjuvant Treatment in Patients With Mild Symptoms of COVID-19
COVID-19 virus remains in infected patients for extended periods of time. A great resource burden is placed on the healthcare system and society at large to isolate COVID-19 patients for prolonged periods.
- Trial name
- NCT04433013
- Testing
- Lianhua Qingwen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Covid19
Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure
This Phase 2 Randomized Placebo Controlled Trial will determine if administering nebulized Dornase Alpha (rhDNase) to COVID-19 patients with respiratory failure is safe and will reduce 28-day mortality.
- Trial name
- DAMPENCOVID (NCT04445285)
- Testing
- Pulmozyme/ Recombinant human deoxyribonuclease (rh-DNase), 0.9%sodium chloride
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Jon Simmons
Covid19, Muscle Atrophy
Electrical Stimulation for Critically Ill Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- Covid19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase I (NCT04685213)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Covid-19 Patients
Is Adipose Tissue a Reservoir for SARS-Cov2 Spread in Covid-19 Patients?
Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.
- Trial name
- TA/SARS-Cov2 (NCT04427878)
- Testing
- biopsies of subcutaneous adipose tissue
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
COVID-19
Collecting Respiratory Sound Samples From Corona Patients to Extend the Diagnostic Capability of VOQX Electronic Stethoscope to Diagnose COVID-19 Patients
Technological developments in the recent decades has enabled the integration of electronic and digital components in the stethoscope design, in an attempt to improve auditory performance and, moreover, to assist in improving…
- Trial name
- NCT04910191
- Testing
- Electronic stethoscope
- Where
- 3 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sanolla
COVID-19
A Specific miRNA Encoded by SARS-CoV-2 as a Diagnostic Tool to Predict Disease Severity in COVID-19 Patients
Coronavirus disease is caused by SARS-CoV-2, known as 2019 novel coronavirus (2019-nCoV). To date has caused a large number of deaths causing serious respiratory illness such as pneumonia and lung failure, therefore representing…
- Trial name
- CoV-miR (NCT05739513)
- Testing
- miRNA analysis in plasma
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
To Assess the Reduction in the Viral Load of SARS-CoV-2 in Patients Receiving Ivermectin Compared to Those Receiving Standard Care
Evaluation of the Impact of the Administration of Single Dose of Ivermectin in the Early Phase of COVID-19
The action of ivermectin in vitro on the viral replication of SARS-CoV-2 was demonstrated and published by an Australian team in June 2020.
- Trial name
- IVERCoV (NCT05040724)
- Testing
- Ivermectin
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Raincy Montfermeil Hospital Group
Hypertension
Personalised Electronic Record Supported Optimisation When Alone for Patients With Hypertension
This trial is focusing on blood pressure control for patients with high blood pressure (hypertension) during the COVID-19 pandemic when seeing a doctor for advice may be difficult.
- Trial name
- PERSONALCovdBP (NCT04559074)
- Testing
- Amlodipine
- Where
- 2 sites in United Kingdom
- Volunteers
- 343 people
- Sponsor
- Queen Mary University of London
Penetrating Injury, COVID-19
Social Determinants of Health in Patients With Penetrating Trauma Injuries Before and During the COVID-19 Pandemic
Investigators report on the impact of the COVID-19 stay-at-home order concerning penetrating violence and its association within different socioeconomic regions within the county.
- Conditions
- Penetrating Injury, COVID-19, Social Determinants of Health
- Trial name
- NCT06135610
- Testing
- Postive SAR-CoV-2 PCR nasopharyngeal swab
- Where
- United States
- Volunteers
- 803 people
- Sponsor
- Kern Medical Center
SARS-CoV-2 Infection
The Efficacy of Azvudine and Paxlovid in High-risk Patients With COVID-19: A Prospective Randomized Controlled Trial
This is a randomized controlled clinical study on the clinical efficacy of Azvudine and Paxlovid antivirus therapy in COVID-19 patients with high-risk.
- Trial name
- NCT05642910
- Testing
- Azvudine, Paxlovid group
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Southeast University, China
Parkinson Disease, Diabetes Mellitus
Health Indicators and Patient Reported Outcomes. Identification of Significative Items Aimed at Improving Health Care Procceses.
The objective of this study is to identify key indicators in the follow-up of subjects with different pathologies related to both the person's environment, as well as the perception of their health and general quality of life and…
- Conditions
- Parkinson Disease, Diabetes Mellitus, COVID-19, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OUTCOMES (NCT05343962)
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Instituto de Biomecanica de Valencia
Multiple Sclerosis, Clinically Isolated Syndrome
Autoimmune Intervention Mastery Course Study
The goal of this project is to critically evaluate the effectiveness of using an online program to improve diet and self-care in patients with multiple sclerosis (MS), clinically isolated syndrome (CIS), fibromyalgia, post acute…
- Conditions
- Multiple Sclerosis, Clinically Isolated Syndrome, Fibromyalgia, Post Acute Sequelae of COVID-19
- Trial name
- AIM (NCT05057676)
- Testing
- Immediate Autoimmune Intervention Mastery Course (AIM), Immediate Question and Answer sessions. (AIM Q and A sessions), Delayed Autoimmune Intervention Mastery Course (delayed AIM course)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Terry L. Wahls
SARS-CoV-2
Analysis of the Inflammatory Response and the Development of Humoral and Cellular Immunity in Patients With COVID-19
The SARS-CoV-2 infection in the airway epithelium induces cytopathic effects and the cessation of ciliary movement. Increased cytokines and chemokines have been reported to be associated with the severity of the disease.
- Trial name
- NCT04423640
- Testing
- Active COVID-19 disease
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Sepsis, Blood Coagulation Disorders
Analysis of the Coagulopathy Developed by COVID-19 Infected Patients
Increased D-dimers at admission of COVID-19 infected patients entering hospital due to a severe disease is a risk factor for death.
- Conditions
- Sepsis, Blood Coagulation Disorders, Thrombin, Disseminated Intravascular Coagulation
- Trial name
- COVID-TGT (NCT04356950)
- Testing
- Thrombin generation test assay, Fibrin generation markers assays
- Where
- 4 sites in France
- Volunteers
- 175 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Covid19
COVID-19 Project ECHO in Nursing Homes
Nursing homes are ground zero for the COVID-19 pandemic. Nursing homes are ill-equipped for the pandemic; though facilities are required to have infection control staff, only 3% have taken a basic infection control course.
- Trial name
- NCT04499391
- Testing
- Project ECHO
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome)
EFFICACY and SAFETY OF BEVACIZUMAB (ZIRABEV®) IN PATIENTS WITH SEVERE HYPOXEMIC COVID-19
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the most frequent complications of the COVID-19 pandemic.
- Conditions
- Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Virus Diseases, Coronaviridae Infections
- Trial name
- BEVA (NCT04822818)
- Testing
- BEVA+SOC, SOC
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgery, COVID
Surgery During Covid-19: The Role of Asymptomatic Patients, a Survey
a brief questionnaire to get a clearer picture of the situation regarding surgical patients with special emphasis on asymptomatic Covid-19 patients.
- Conditions
- Surgery, COVID, Asymptomatic Patient, Covid-19
- Trial name
- NCT04344197
- Testing
- global survey
- Where
- Italy
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Rome Tor Vergata