Clinical trials: Covid-19 Patients
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Tocilizumab for Patients With Cancer and COVID-19 Disease
This phase II expanded access trial will study how well tocilizumab works in reducing the serious symptoms including pneumonitis (severe acute respiratory distress) in patients with cancer and COVID-19.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Pneumonia, Pneumonitis
- Trial name
- NCT04370834
- Testing
- Tocilizumab
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
COVID - 19, Renal Transplant
Safety and Effectiveness of a Remdesivir Treatment to Prevent Severe COVID-19 in Kidney Transplant Patients
Since the start of the COVID-19 pandemic, the approach to solid organ transplantation has evolved. Transplants using organs (excluding lungs) from COVID-19-positive donors have shown short-term safety, but there is limited data…
- Conditions
- COVID - 19, Renal Transplant, SARS CoV 2 Infection
- Trial name
- COVIDKIDNEY (NCT07197164)
- Testing
- Remdesivir (RDV)
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
SARS-CoV Infection
Efficacy and Safety of Ozonised Oil (HOO) in COVID-19 Patients
The anti-viral efficacy of ozone against RNA viruses is already established. Ozone gas have been already proposed as possible therapy for Covid-19 infection with insofar limited success.
- Trial name
- HOO-COVID (NCT04651387)
- Testing
- Ozonized oil (HOO
- Sponsor
- Neuromed IRCCS
Corona Virus Infection, COVID-19
Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Patients With COVID19
Suspension of Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Hospitalized Patients With Coronavirus Infection.
- Trial name
- BRACE-CORONA (NCT04364893)
- Testing
- Suspension or Maintenance of Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors
- Where
- Brazil
- Volunteers
- 700 people
- Sponsor
- D'Or Institute for Research and Education
Corona Virus Infection, Post-traumatic Stress Disorder
Psychological Burden in ICU Survivors of Severe COVID-19 Pneumonia, Their Relatives and Their Healthcare Providers
Coronavirus disease 2019 (COVID-19) is an infectious disease responsible for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- BURDENCOV (NCT04341519)
- Testing
- PTSD, Burnout
- Where
- 3 sites in France
- Volunteers
- 1,464 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronavirus Infection, Covid-19
Pilot Study of Ensifentrine or Placebo Delivered Via pMDI in Hospitalized Patients With COVID-19
This pilot study is being performed to assess the efficacy and safety of inhaled ensifentrine delivered via pMDI compared with a matching placebo in conjunction with standard of care treatments on recovery in patients…
- Conditions
- Coronavirus Infection, Covid-19, SARS-CoV-2
- Trial name
- NCT04527471
- Testing
- Ensifentrine Dose 1
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Verona Pharma Inc
SARS-CoV-2 Acute Respiratory Disease, SARS-CoV2 Infection
Exploratory Regimen of Basiliximab for Treatment of Pulmonary Cytokine Storm in SARS-CoV-2 Hospitalized Adult Patients
To explore the efficacy of treatment of pulmonary cytokine storm induced by SARS-CoV2 with a monoclonal antibody to IL-2 (Basiliximab) in addition to current standard of care vs current standard of care with the primary efficacy…
- Conditions
- SARS-CoV-2 Acute Respiratory Disease, SARS-CoV2 Infection, Cytokine Storm
- Trial name
- FWCSWG-IL-2 (NCT05013034)
- Testing
- Basiliximab Injection
- Volunteers
- 300 people
- Sponsor
- Fort Worth Clinical Sciences Working Group
Post-COVID ME/CFS
Repeat Immunoadsorption Post Covid ME/CFS
The evidence for an autoimmune etiology in postinfectious myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is growing.
- Trial name
- NCT05629988
- Testing
- IA with TheraSorb ® column
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
COVID-19, Headache
Brain Structural Abnormalities in Patients with Post-COVID-19 Headache
Introduction: The clinical manifestations of the COVID-19 pandemic are heterogeneous and may include various symptoms (gastrointestinal, musculoskeletal, neurological).
- Conditions
- COVID-19, Headache, MRI
- Trial name
- NCT06825741
- Testing
- Observational Study - No intervention
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- University of Pecs
Solid Tumor, Hematologic Malignancy
COVID-19 Vaccine Efficacy in Patients With Malignant Pathologies
In the context of malignant disease, it is likely that vaccine efficacy and immunogenicity depends on the type of pathology, stage of the disease, immunosuppression induced by the treatments, in addition to more classic factors…
- Conditions
- Solid Tumor, Hematologic Malignancy, Thoracic Cancer, Cancer, Treatment-Related
- Trial name
- COVIDVAC OH (NCT04776005)
- Testing
- Data collection
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Failure
Pronostic Value of Type I ANTi-Interferon Antibodies in Patients With COVID-19 Acute Respiratory Failure
Severe SARS-CoV-2 infections are frequently associated with the acute respiratory distress syndrome (ARDS), which leads to a mortality of 30-40%.
- Trial name
- ANTICOV (NCT04733105)
- Where
- France
- Volunteers
- 1,022 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
Study of Merimepodib in Combination With Remdesivir in Adult Patients With Advanced COVID-19
The purpose of this study is to assess the safety and efficacy of merimepodib (MMPD) oral solution when administered in combination with remdesivir in adult patients with advanced COVID-19.
- Trial name
- NCT04410354
- Testing
- Merimepodib, Remdesivir
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- ViralClear Pharmaceuticals, Inc.
Kidney Transplant, Pancreatic Transplat
SARS-CoV2 (COVID-19) Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)
Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.
- Conditions
- Kidney Transplant, Pancreatic Transplat, Pancreatic Islets Langerhans
- Trial name
- NCT04487197
- Testing
- blood sample for seroepidemiological investigation
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- Antonio Secchi
Corona Virus Infection
Efficacy of Inhaled Nitroglycerin in Moderate to Critically Ill COVID-19 Patients
In current analysis moderate to severely ill Covid-19 infected patients will be nebulized with nitroglycerin, and they will be compared with the standard nebulization
- Trial name
- NCT04686760
- Testing
- Nitroglycerin
- Where
- Pakistan
- Volunteers
- 278 people
- Sponsor
- University of Lahore
COVID-19
Lymphocyte to Procalcitonin Ratio in Covid-19 Patients
The lymphocyte/CRP ratio has been studied many times in covid-19 patients and has been proven to be an indicator of mortality as well as poor prognosis.
- Trial name
- NCT06620159
- Where
- Turkey (Türkiye)
- Volunteers
- 535 people
- Sponsor
- Suleyman Demirel University
COVID-19, Mental Health Impairment
A Study on a Digital Platform for COVID19+ Patients, Designed to Facilitate Communication and Mental-health Care During and After Hospitalization.
This study presents a digital mental-health protocol designed to offer remote, personalized support to former or current COVID-19 patients. A total of 100 subjects will be enrolled.
- Conditions
- COVID-19, Mental Health Impairment, Telemedicine
- Trial name
- DigiCOVID (NCT05231018)
- Testing
- Psychotherapy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
COVID-19
Clinical Decision Support System Based on Non-invasive Tele-monitoring of COVID-19 Patients
The aim of the study is to provide clinical decision support to healthcare professionals using a wearable for non-invasive multimodal monitoring, allowing early detection of disease progression to severe forms, as well as the…
- Trial name
- SOY+ (NCT04802018)
- Testing
- Clinical decision support system based on non-invasive multimodal monitoring
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Increase-Tech
COVID-19
Impact of the CT Scan in Patients With Suspected Covid-19
The diagnostic performance of the scanner in the indication of suspected Covid-19 is not yet well known, especially in comparison with the results of RT-PCR.
- Trial name
- SCAN-COV-HUS (NCT05079191)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Strasbourg, France
COVID
COVID-EC Study: Clinical Characteristics of Patients With COVID-19 in Guayaquil, Ecuador
In December 2019, an outbreak of pneumonia of initially unknown cause was detected in Wuhan (Hubei, China), and it was quickly determined that it was caused by a new coronavirus, that is, the SARS-CoV- 2 virus, causing the…
- Trial name
- NCT04362969
- Where
- Ecuador
- Volunteers
- 300 people
- Sponsor
- Hospital San Carlos, Madrid
SARS-CoV 2, Hospitalisation-Associated Infection
Protein Electrophoresis as a Tool for Complications Prediction in COVID-19 Hospitalised Patients
The inflammation is central in COVID-19 infections. Our aim is to evaluate the clinical value of measuring inflammation by using serum protein electrophoresis (SPE).
- Trial name
- COVELEC (NCT04414059)
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Elsan
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