Clinical trials: Covid-19 Patients
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Covid19, Corona Virus Infection
Study Designed to Evaluate the Effect of CimetrA in Patients Diagnosed With COVID-19
Multi-center multinational-controlled study in Israel, Brazil, Spain, and South-Africa. 240 adult patients who suffer from moderate COVID-19 infection.
- Trial name
- CimetrA (NCT05037162)
- Testing
- Biochemistry blood test, Hematology blood test, D-Dimer test (coagulation)
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- MGC Pharmaceuticals d.o.o
Covid19, SARS-CoV Infection
Tenofovir-DF Versus Hydroxychloroquine in the Treatment of Hospitalized Patients With COVID-19 (TEDHICOV)
Although several therapeutic agents have been suggested for the treatment of the disease caused by the Coronavirus of the year 2019 (COVID-19), no antiviral has yet demonstrated consistent efficacy.
- Conditions
- Covid19, SARS-CoV Infection, Tenofovir
- Trial name
- TEDHICOV (NCT04812496)
- Where
- Peru
- Volunteers
- 100 people
- Sponsor
- Hospital Nacional Carlos Alberto Seguin Escobedo - EsSalud
COVID-19 (Coronavirus Disease 2019), COVID-19 Pandemic
University Hospital of Ioannina COVID-19 (Coronavirus Disease 2019) Registry
COVID-19 (Coronavirus Disease 2019) Registry of University Hospital of Ioannina. Retrospective datasource registry with quantitative and qualitative patient data from the hospital medical records.
- Conditions
- COVID-19 (Coronavirus Disease 2019), COVID-19 Pandemic, COVID-19 Pneumonia, COVID-19 Respiratory Infection
- Trial name
- NCT05534074
- Where
- Greece
- Volunteers
- 2,500 people
- Sponsor
- University Hospital, Ioannina
Apnea, Obstructive Sleep, SARS CoV 2 Infection
Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients
Sleep is an important modulator of the immune response, whereby sleep disturbances (ie, poor sleep quality, insufficient sleep and/or primary sleep disorder, obstructive sleep apnea (OSA)) contribute to inflammatory disease risk…
- Trial name
- NCT06341374
- Testing
- Influvac Tetra
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Parc Taulí Hospital Universitari
COVID
Efficacy of Convalescent Plasma Therapy in Severely Sick COVID-19 Patients
Currently, no effective treatments are available for the COVID-19 pandemic, which is related to more than 70,000 deaths all over the world.
- Trial name
- NCT04346446
- Testing
- Convalescent Plasma Transfusion, Supportive Care, Random Donor Plasma
- Where
- 2 sites in India
- Volunteers
- 29 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Covid-19, Hypoxia
Hydrocortisone for COVID-19 and Severe Hypoxia
We aim to assess the benefits and harms of low-dose hydrocortisone in patients with COVID-19 and severe hypoxia.
- Trial name
- COVID STEROID (NCT04348305)
- Testing
- Hydrocortisone, Sodium Chloride 9mg/mL
- Where
- 14 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Scandinavian Critical Care Trials Group
COVID-19, Hormone Replacement Therapy
Short-term Effects of Transdermal Estradiol on Female COVID-19 Patients
The goal of this randomized placebo-controlled study is to investigate the short-term effects of transdermal estrogen therapy on postmenopausal women with COVID-19 disease.
- Trial name
- NCT05774405
- Testing
- Climara 0.1Mg/24Hr Transdermal System, Hydrogel patch
- Where
- Turkey (Türkiye)
- Volunteers
- 9,169 people
- Sponsor
- Istanbul University - Cerrahpasa
Respiratory Disease, Asthma
Digital App for Telerehabilitation in Respiratory Diseases
The purpose of this study is to evaluate the feasibility and the mid-term effects of a pulmonary rehabilitation intervention, delivered by digital App, on quality of life of patients affected by respiratory diseases.
- Conditions
- Respiratory Disease, Asthma, Long COVID, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05572346
- Testing
- Home-based telerehabilitation program delivered through digital devices
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- MedicAir Healthcare S.r.l.
COVID-19, Mechanical Ventilation
Dornase Alfa Administered to Patients With COVID-19 (DACOVID)
Mechanically ventilated patients with coronavirus disease 2019 (COVID-19) have a mortality of 24-53%, in part due to distal mucopurulent secretions interfering with ventilation.
- Trial name
- DACOVID (NCT04387786)
- Testing
- Dornase Alfa
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Feinstein Institute for Medical Research
Hemophilia Arthropathy
COVID-19 Quarantine on Musculoskeletal Status in Hemophilia
Background. The recurrence of hemarthrosis in patients with congenital coagulopathies favors the development of a progressive, degenerative and intra-articular lesion (hemophilic arthropathy) that mainly affects the knees, ankles…
- Trial name
- HemoCov (NCT04491318)
- Testing
- Observational
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Investigación en Hemofilia y Fisioterapia
ARDS Due to COVID-19
Surfactant-BL in Adult Acute Respiratory Distress Syndrome Due to COVID-19
The purpose of this study is to prove the efficacy and safety Surfactant-BL, administered by inhalation in adult hospitalized patients with ARDS due to COVID-19.
- Trial name
- NCT04568018
- Testing
- Surfactant
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Biosurf LLC.
COVID-19 Infection
Evaluate the Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cells in Patients With COVID-19
This study is to explore the safety and efficacy of using UCMSC01 in patients with COVID-19 infection via IV stem cell administration.
- Trial name
- UMSC01 (NCT05501418)
- Testing
- Allogeneic umbilical cord mesenchymal stem cells, Controlled normal saline
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- Ever Supreme Bio Technology Co., Ltd.
Covid19_rehabilitation
Recovery Profiles in Patients With SARS-CoV-2 Outcomes Undergoing Rehabilitation
COVID19 patients survivors, after discharge from hospital show reduced lung function and reduced ability to exercise. Furthermore, mental health problems including stress, anxiety and depression and a low quality of life were…
- Trial name
- NCT04615390
- Testing
- Early rehabilitation, Subacute rehabilitation, Mindfulness training
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Covid19
Bucillamine in Treatment of Patients With COVID-19
This is a Phase 3, multi-center, randomized, double blind, placebo controlled, clinical study of bucillamine (2 dosage levels) in patients with mild-moderate COVID-19.
- Trial name
- NCT04504734
- Testing
- Bucillamine
- Where
- 47 sites in United States, Puerto Rico
- Volunteers
- 713 people
- Sponsor
- Revive Therapeutics, Ltd.
COVID-19 Pneumonia
Tocilizumab in COVID-19 Pneumonia (TOCIVID-19)
This study project includes a single-arm phase 2 study and a parallel cohort study, enrolling patients with COVID-19 pneumonia.
- Trial name
- TOCIVID-19 (NCT04317092)
- Testing
- Tocilizumab Injection
- Where
- 27 sites in Italy
- Volunteers
- 402 people
- Sponsor
- National Cancer Institute, Naples
COVID-19 Acute Respiratory Distress Syndrome
Personalized Targeted Immunomodulation in COVID-19 ARDS
Rationale: In COVID19 single-targeted immunomodulation, mostly via an IL-6 receptor blocker, was used by a one-size fits all non-targeted approach. In future pandemics the same might occur.
- Trial name
- COMODULATE (NCT06311448)
- Testing
- Single target immunomodulation, Standard of care
- Where
- Netherlands
- Volunteers
- 164 people
- Sponsor
- Erasmus Medical Center
Infertility, Female, ART
Impact of COVID-19 on Psychological Status in Case of IVF Interrupted or Postponed
Infertility is a severely distressing experience for many couples. Depression and anxiety are psychological disorders associated with infertility, and they may worsen during infertility treatments.
- Conditions
- Infertility, Female, ART, IVF, COVID-19
- Trial name
- NCT04395755
- Testing
- Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9)
- Where
- Italy
- Volunteers
- 503 people
- Sponsor
- Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia
COVID-19, SARS-CoV-2
PEP Flute-selfcare in COVID-19
Most research on the coronavirus SARS-CoV-2 and COVID-19 disease relate to screening measures, development of vaccines and optimising treatment of hospitalised patients.
- Trial name
- PEP-CoV (NCT04530435)
- Testing
- PEP flute
- Where
- Denmark
- Volunteers
- 378 people
- Sponsor
- Bispebjerg Hospital
COVID-19 Respiratory Infection, Aspergillosis
Posaconazole Prophylaxis for CAPA Prevention in Critically-Ill Patients
COVID-19 associated pulmonary aspergillosis (CAPA) is considered a potentially life-threatening infection in critically ill COVID (Corona Virus disease)-19 patients.
- Trial name
- POSACOVID (NCT05065658)
- Testing
- Posaconazole
- Where
- 3 sites in Austria, France and 1 more
- Volunteers
- 249 people
- Sponsor
- Medical University of Graz
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