Clinical trials: Covid-19 Patients
Presence of COVID-19 Compatible CT Abnormalities
CT Abnormalities Evocative of Lung Infection Are Associated With Lower 18F-FDG Uptake in Confirmed COVID-19 Patients
CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas 18F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 18F-FDG-PET signs in patients that were (i)…
- Trial name
- NCT04512118
- Testing
- PET-CT of 18F-FDG
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Central Hospital, Nancy, France
Acute Respiratory Distress Syndrome, COVID-19
Construction of a Composite Clinical-echo Score Predictive of a Risk of Short-term Aggravation of Respiratory Impairment in Patients Suspected of Covid-19
With the influx of patients suspected of Covid-19 and the limited number of hospital beds, there is a need for sensitive triage to detect patients at risk of pulmonary complications and therefore requiring hospitalization, but…
- Trial name
- VIRUS (NCT04370249)
- Testing
- pulmonary ultrasound
- Where
- France
- Volunteers
- 313 people
- Sponsor
- Nantes University Hospital
Covid19
Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2 (COVID-19) Infection
This study proposes to evaluate the therapeutic efficacy, immunologic effects and normalization of laboratory parameters for patients at high risk for mortality when infected by SARS-CoV-2 (COVID-19) when administered one unit…
- Trial name
- NCT04513158
- Testing
- Convalescent Plasma
- Where
- 4 sites in United States
- Volunteers
- 2 people
- Sponsor
- Joseph M. Flynn, D.O., MPH
COVID-19
Convalescent Plasma as a Possible Treatment for COVID-19
Patients who are ill with COVID-19 may benefit from receiving convalescent plasma infusions containing antibodies from donors who have recovered from the disease and are proven to no longer be infected.
- Trial name
- NCT04442191
- Testing
- Convalescent plasma
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Covid19
Chest Radiography in COVID-19 Patients
To assess the prognostic performance of the RALE score with respect to duration of ventilation, and to describe changes in the RALE score over time.
- Trial name
- NCT04485338
- Where
- Netherlands
- Volunteers
- 139 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cancer
COVID-19 Infection Screening in Cancer Patients (NEOSCREENCOVID)
Since December 2019, outbreak of COVID-19 caused by a novel virus SARS-Cov-2 has spread rapidly around the world and became a pandemic issue.
- Trial name
- NEOSCREENCOVID (NCT04492410)
- Testing
- rapid serological test
- Where
- France
- Volunteers
- 214 people
- Sponsor
- Centre Antoine Lacassagne
Covid19, Coronavirus Infection
Utility of Empiric Antibiotics for Non-intubated Novel Coronavirus Diseases 2019 Patients
This retrospective analysis of inpatient data obtained from administrative and electronic medical records will investigate the role of empiric antibiotics on admission on the mortality for non-intubated patients presenting with…
- Conditions
- Covid19, Coronavirus Infection, Pneumonia
- Trial name
- NCT04674410
- Testing
- Antibiotic
- Where
- United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
COVID-19
Plasma Exchange in Covid-19 Patients With Anti-interferon Autoantibodies
COVID-19 associated mortality remains high despite the advances in therapeutics such as dexamethasone. The severity of COVID-19 results from direct viral cytotoxicity, and the inflammatory response, which is associated with a…
- Trial name
- EPIC (NCT05182515)
- Testing
- Therapeutic plasma exchange
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier St Anne
Covid19
Efficacy of Convalescent Plasma to Treat COVID-19 Patients, a Nested Trial in the CORIMUNO-19 Cohort
The coronavirus disease 2019 (COVID-19) viral pneumonia is now a worldwide pandemic caused by the Severe acute respiratory virus coronavirus 2 (SARS-CoV-2).
- Trial name
- CORIPLASM (NCT04345991)
- Testing
- Transfusion of COVID-19 convalescent plasma
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ARDS: Acute Respiratory Distress Syndrome, Covid19
Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS
The goal of this observational study is to learn about the effect of steroid therapy in patients with COVID-19 ARDS. The main questions it aims to answer are: Differences between patients with COVID-19 ARDS before and after…
- Trial name
- NCT05933291
- Testing
- steroid
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking Union Medical College Hospital
Enteral Nutrition, COVID-19 Acute Respiratory Distress Syndrome
Early Versus Delayed Enteral Nutrition in Critically Ill Adults With COVID-19
The goal of this observational study is to determine the relationship between the nutritional profile of critically ill patients diagnosed with COVID-19 and disease severity, prognosis, and survival, to assess the ability to meet…
- Trial name
- NCT06134674
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Ankara City Hospital Bilkent
Autoimmune Diseases, Inflammatory Disorder
Immunological Response to COVID-19 Vaccine in Patients With Autoimmune and Inflammatory Diseases Treated With Immunosuppressants and/or Biologics
Vaccination against the new coronavirus (SARS-CoV-2) was extended to patients at risk of severe forms of Covid-19, including in particular patients with autoimmune and inflammatory diseases treated by immunosuppressants and/or…
- Trial name
- COVADIS (NCT04870411)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19, SARS (Disease)
Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19:
Recently, a new clinical presentation called "long covid" has been reported, for patients with symptoms lasting for more than 4 weeks from the onset of the disease.
- Trial name
- E-SPERANZA (NCT04695704)
- Testing
- Montelukast
- Where
- 8 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Covid19
Pronation in COVID-19 Patients Undergoing Non Invasive Respiratory Support
Pronation seems feasible and effective in improving blood oxygenation in patients with COVID-19 pneumonia. Data are lacking on the effects of pronation on clinical outcome in this subset of patients.
- Trial name
- PRINCESS (NCT04649658)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- University of Modena and Reggio Emilia
COVID-19 Pneumonia, Nutrition, Healthy
The Role of Olive Oil in the Treatment of Covid-19 Pneumonia
Objective: Consuming natural olive oil in patients diagnosed with COVID-19 Pneumonia may strengthen immunity, slow down disease progression, and lower mortality.
- Trial name
- NCT06677658
- Testing
- Olive Oil, Methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Giresun University
COVID-19
Clinical Outcomes of paTients pREsenting to HArare COVID-19 CenTer of Excellence With SARS-CoV-2 Infection
In order to influence COVID-19 treatment guidelines, evidence on disease progression and clinical outcomes of hospitalized COVID-19 patients, particularly those receiving innovative COVID-19 medications in an African setting is…
- Trial name
- TREAT (NCT05529771)
- Where
- Zimbabwe
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
COVID-19
Counter-Regulatory Hormonal and Stress Systems in Patients With COVID-19
The COVID-19 pandemic is associated with a highly variable presentation, ranging from patients who are asymptomatic or experience only mild symptoms to others with acute respiratory syndrome (ARDS) who require ventilatory support…
- Trial name
- CROSS-CO19 (NCT05736900)
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COVID-19
Chloroquine as Antiviral Treatment in Coronavirus Infection 2020
The aim of the study is to evaluate whether the therapy with chloroquine phosphate (CQ, in combination with telemedical approach) in addition to standard care is effective and safe in reducing composite endpoint of…
- Trial name
- NCT04331600
- Testing
- Chloroquine phosphate, Telemedicine
- Where
- 2 sites in Poland
- Volunteers
- 16 people
- Sponsor
- Wroclaw Medical University
COVID-19
Low-cost Sensor System for COVID-19 Patient Monitoring: Validation of BRAEBON Vital Signs Monitor (VTS)
The BRAEBON VTS is a low-cost, portable device that is being developed to take continuous and real-time vital sign measurements of COVID-19 patients, both in the hospital and home setting.
- Trial name
- NCT05029011
- Testing
- BRAEBON VTS
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Helen S. Driver, PhD
Covid19, Pneumonia, Viral
Nebulized Heparin for the Treatment of COVID-19
Randomized, placebo controlled study to determine if nebulized heparin may reduce the need for mechanical ventilation in hospitalized patients with the novel coronavirus, also known as COVID-19.
- Trial name
- INHALE-HEP (NCT04723563)
- Testing
- Heparin, 0.9%sodium chloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Frederick Health
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