Clinical trials: Covid-19 Patients
Tracheostomy, Characteristics Disease
Early SARS-CoV-2 Tracheostomy
Objective of this case series was to evaluate the characteristics of early COVID-19 tracheostomy and its effect on laboratory parameters.
- Conditions
- Tracheostomy, Characteristics Disease, Metabolic Disturbance
- Trial name
- NCT05520957
- Testing
- Tracheostomy
- Where
- Bosnia and Herzegovina
- Volunteers
- 17 people
- Sponsor
- Cantonal Hospital Zenica
COVID-19
Tocilizumab to Prevent Clinical Decompensation in Hospitalized, Non-critically Ill Patients With COVID-19 Pneumonitis
Coronavirus disease-2019 (COVID-19) has a quoted inpatient mortality as high as 25%. This high mortality may be driven by hyperinflammation resembling cytokine release syndrome (CRS), offering the hope that therapies targeting…
- Trial name
- COVIDOSE (NCT04331795)
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Chicago
SARS-CoV-2, COVID-19
eVusheld Assessment reaL wORld Effectiveness in Israel Clalit Health Services
An AstraZeneca-sponsored observational, electronic healthcare record (EHR)-embedded retrospective cohort study to assess the real-world effectiveness of EVUSHELD against SARS-CoV-2 infection, COVID-19-related hospitalization, and…
- Trial name
- VALOR C19 IL (NCT05712096)
- Testing
- EVUSHELD
- Where
- Israel
- Volunteers
- 4,000 people
- Sponsor
- AstraZeneca
COVID-19
Clinical and Biological Predictors of COVID-19 Disease in Older Patients
The project is an observational, prospective study. Its aim is to deepen our understanding of COVID-19 in older patients hospitalized and diagnosed with COVID-19.
- Trial name
- NCT04348396
- Where
- 3 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Covid19, Myocardial Injury
Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19
COVID-19 infection has been associated with numerous cardiac manifestations. Indeed, SARS-CoV-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or…
- Conditions
- Covid19, Myocardial Injury, Cardiovascular Diseases, Heart Failure
- Trial name
- CARDIO-COVID (NCT04624503)
- Where
- 5 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Humanitas Hospital, Italy
Covid19
NeuroCovid - a Study of Intensive Care-requiring Covid-19 Patients
Critically ill patients requiring intensive care suffer to a large extent from cognitive deficits involving higher brain functions that primarily affect memory, learning and the ability to concentrate.
- Trial name
- NCT04578197
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Multiple Myeloma, Covid19
Analysis of the Immune Parameters of COVID-19 Infection in Patients With Multiple Myeloma
Among all MM patients included in the cohort at the time of diagnosis of SARS-CoV-2 infection, blood samples will be collected at inclusion, at time of the infection acute phase in the most severe cases (when admitted in…
- Trial name
- Covimmunomm (NCT04805203)
- Testing
- blood sample analyses
- Where
- 53 sites in France
- Volunteers
- 139 people
- Sponsor
- Intergroupe Francophone du Myelome
Coronavirus, COVID
Darunavir/Cobicistat vs. Lopinavir/Ritonavir in COVID-19 Pneumonia in Qatar
Coronavirus Disease 2019 (COVID-19) is a disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus.
- Conditions
- Coronavirus, COVID, Pneumonia
- Trial name
- DOLCI (NCT04425382)
- Testing
- Darunavir/Cobicistat, Lopinavir/Ritonavir
- Where
- Qatar
- Volunteers
- 400 people
- Sponsor
- Hamad Medical Corporation
Chronic Pain, Post ICU Syndrome
Persistent Pain and Its Impact on Quality of Life COVID-19 Patients That Required Critical Care
COVID-19 infection produces thousands of hospital admissions in a very short period of time, including critical care patients. It is expected that those who survive a severe spectrum of the disease, will present some degree of…
- Conditions
- Chronic Pain, Post ICU Syndrome, Quality of Life
- Trial name
- NCT04887220
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
COVID-19 Respiratory Infection
Dynamics of Markers of Infection and Inflammation in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients
Patients requiring admission to the hospital due to a moderate and severe COVID-19 infection may differ in their ability to respond to viral infection and to eliminate viral load.
- Trial name
- NCT04887623
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Hradec Kralove
COVID-19, ARDS, Human
MRG-001 as an Immunoregulatory and Regenerative Therapy for COVID-19 Patients
This study consists of two parts. Part A (Phase I): A Phase I Double-blind Randomized Placebo-controlled Study in Healthy Subjects to Assess the Safety, Pharmacokinetics, Pharmacodynamics of MRG-001 Part B (Phase 2): A Phase IIa…
- Conditions
- COVID-19, ARDS, Human, Stem Cells, Regeneration
- Trial name
- NCT04646603
- Testing
- MRG-001
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- MedRegen LLC
Corona Virus Infection
Effect of Interleukin 6 Receptor Antagonists in SARS-CoV-2 Patients
1. Investigate the possible effects of interleukin-6 receptor antagonists such as tocilizumab and sarilumab on the levels of IL-6, inflammtory and anti-inflammtory markers and cytokines before and after treatment in critically…
- Trial name
- NCT05367882
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Assiut University
COVID-19
COVID-19 Convalescent Plasma (CCP) Transfusion
This research study evaluates the safety and effectiveness for the use of convalescent plasma transfusion as a treatment option for novel coronavirus SARS-CoV-2 infection (COVID-19).
- Trial name
- NCT04412486
- Testing
- COVID Convalescent Plasma
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Gailen D. Marshall Jr., MD PhD
Mesenchymal Stem Cell, COVID-19 Pneumonia
UC-MSCs in the Treatment of Severe and Critical COVID-19 Patients
The goal of this randomized, controlled, open-labeled interventional clinical trial is to test the efficacy and safety of umbilical cord mesenchymal stem cells (UC-MSCs) in the treatment of severe and critical COVID-19 patients.
- Trial name
- NCT05682586
- Testing
- umbilical cord mesenchymal stem cells, paxlovid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai East Hospital
COVID-19, Cardiovascular Diseases
The McGill RAAS-COVID-19 Trial
Coronavirus disease (COVID-19) related pneumonia significantly impact patients with underlying cardiovascular (CV) conditions. Animal studies suggest that drugs commonly used to treated CV diseases may increase the ability of…
- Trial name
- RAAS-COVID (NCT04508985)
- Testing
- Temporarily holding the RAAS inhibitor [intervention], RAAS inhibitor [continued standard of care]
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Tracheostomy Complication, Covid19
A Cohort Study of Mechanically Ventilated COVID-19 Patients Undergoing Tracheostomy
COVIDTrach aims to assess the outcomes of tracheostomy in mechanically ventilated patients with COVID-19. The use of personal protective equipment and incidence of COVID-19 amongst operators is also recorded.
- Conditions
- Tracheostomy Complication, Covid19, Ventilator Lung
- Trial name
- COVIDTrach (NCT04572438)
- Testing
- Tracheostomy
- Where
- United Kingdom
- Volunteers
- 2,234 people
- Sponsor
- University College, London
Kidney Transplant Patients
The Effect of Neuro Linguistic Programming on COVID-19 Fear in Kidney Transplant
The study was conducted experimentally to evaluate the effect of neurolinguistic programming on COVID-19 fear in kidney transplant patients.
- Trial name
- NCT05115435
- Testing
- neuro linguistic programming
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Inonu University
COVID-19 Infection
Safety and Efficacy Trial of Zavegepant* Intranasal for Hospitalized Patients With COVID-19 Requiring Supplemental Oxygen
The purpose of this study is to determine if a CGRP receptor antagonist may potentially blunt the severe inflammatory response at the alveolar level, delaying or reversing the path towards oxygen desaturation, Acute respiratory…
- Trial name
- NCT04346615
- Testing
- Zavegepant (BHV-3500)
- Where
- 6 sites in United States
- Volunteers
- 47 people
- Sponsor
- Pfizer
COVID-19, Mental Health Disorder
Treatment of Post-covid Syndrome in Patients Treated in Intensive Care
The present study is a pilot randomized controlled trial, which identifies and diagnoses mental health problems in survivors of critical COVID-19 infection at 12 months post-ICU care, and randomize patients to either an…
- Trial name
- NCT05119608
- Testing
- CBT/ACT
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Diabetes, Covid-19
Remote Continues Glucose Monitoring During the COVID-19 Pandemic in Quarantined Hospitalized Patients
This is a randomized controlled trial of isolated patients with diabetes admitted to Nordsjællands Hospital with or without COVID-19-pneumonia.
- Conditions
- Diabetes, Covid-19, Infection
- Trial name
- CGM-ISO (NCT04430608)
- Testing
- Dexcom G6
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Nordsjaellands Hospital
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