Clinical trials: Covid-19 Pneumonia
Patient Preference, COVID-19
Patients' Experiences in a Medicalized Hotel for COVID-19 Acute Care Support
The 11th March 2020, the World Health Organization (WHO) declared the novel coronavirus Covid-19 as a pandemic. Urgent reorganization was required to give answers to the needs of this new illness.
- Trial name
- NCT04503434
- Where
- Spain
- Volunteers
- 517 people
- Sponsor
- Hospital Clinic of Barcelona
SARS-CoV-2 Infection, COVID-19
Evaluation of a Screening Program for SARS-CoV-2 Infection in the General Population Based on the Use of New Detection Approaches or for Diagnostic Orientation on Saliva
The investigators hypothesize that detection of SARS-CoV2 on saliva samples will increase the performance of the screening program compared to the reference strategy (RT-PCR on a nasopharyngeal swab).
- Trial name
- SALICOV (NCT04578509)
- Testing
- Nasopharyngeal swab, Saliva sample, axillary sweat sample
- Where
- France
- Volunteers
- 5,197 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma, COPD
MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology
Lung magnetic resonance imaging (MRI) with proton and inhaled inert gases has demonstrated a clinical ability to provide valuable structural and functional information in lung disease.
- Conditions
- Asthma, COPD, Covid19, Long COVID
- Trial name
- MURDOCH (NCT04872309)
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Coronavirus Disease 2019 (COVID-19) Pneumonia
Phase 3 Study to Evaluate Efficacy and Safety of Lenzilumab in Patients With COVID-19
The primary objective of this study is to assess whether the use of lenzilumab in addition to current standard of care can alleviate the immune-mediated cytokine release syndrome (CRS) and improve ventilator-free survival in…
- Trial name
- NCT04351152
- Testing
- Lenzilumab, Standard of Care
- Where
- 29 sites in United States, Brazil
- Volunteers
- 520 people
- Sponsor
- Humanigen, Inc.
Acute Respiratory Failure, COVID-19
REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
The worldwide COVID-19 pandemic has led to a dramatic increase in the number of patients hospitalized in intensive care units for an acute respiratory failure in all countries.
- Conditions
- Acute Respiratory Failure, COVID-19, Trauma, Stroke
- Trial name
- REHSCU (NCT04611425)
- Testing
- Remimazolam
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Covid19
Clinical Characteristics of Deceased With COVID-19
This study aims to describe the clinical characteristics of patients who died from COVID-19 in the largest hospital in Bangladesh to understand the risk associated with COVID-19 related mortality in this region.
- Trial name
- COVID-19 (NCT04874792)
- Where
- Bangladesh
- Volunteers
- 282 people
- Sponsor
- Dhaka Medical College
COVID-19 Pneumonia
Clinical, Molecular and Functional Biomarkers for PROgnosis, Pathomechanisms and Treatment Strategies of COVID-19
The aim of the joint project PROVID is to contribute to better outcome prediction for COVID-19 patients, to better clinical management, and to the development of new therapies.
- Trial name
- NCT04977934
- Where
- 5 sites in Austria, Germany
- Volunteers
- 94 people
- Sponsor
- Charite University, Berlin, Germany
Covid19, Hemodynamic Instability
Hemodynamic Impact on Critical Care Patients With Lung Damage Secondary to COVID-19
The aim of the present work is to describe the hemodynamic effects shown in patients with ARDS secondary to SARS-CoV-2 infection
- Conditions
- Covid19, Hemodynamic Instability, ARDS, Human
- Trial name
- NCT04556864
- Where
- 5 sites in Spain
- Volunteers
- 67 people
- Sponsor
- Juan Victor Lorente
SARS-CoV-2 Infection, Acute Kidney Injury
Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection
An interventional clinical trial using oral nicotinamide riboside (NR) in hospitalized patients with COVID-19 infection and acute kidney injury to determine the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+)…
- Trial name
- NIRVANA (NCT04818216)
- Testing
- Nicotinamide riboside
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 Infection
Neuropsychiatric Post-Acute Sequelae of SARS-CoV-2 (PASC) Using TSPO Positron Emission Tomography (PET) and MRI
The overarching goal of this study is to develop PET/MR techniques for the diagnosis of neuropsychiatric post-acute sequelae (PASC) of SARS-CoV-2.
- Trial name
- NCT05615415
- Testing
- PET Tracer, MRI Tracer, 3T PET/MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
COVID-19
ApTOLL for the Treatment of COVID-19
There is a clear and urgent medical need of developing new medicinal products for COVID-19 since there are poor pharmacological tools to block the progression of patients to cytokine storm syndrome (CSS).
- Trial name
- NCT05293236
- Testing
- ApTOLL, Saline
- Where
- 4 sites in Spain
- Volunteers
- 5 people
- Sponsor
- Macarena Hernández Jiménez
Bariatric Surgery Candidate, Covid19
Obesity Surgery During 2020 Italian Pandemic
The first person-to-person Coronavirus disease (COVID-19) transmission in Italy was reported on Feb 21st, 2020, causing one of the most massive outbreak in Europe so far that stopped immediately all elective surgical procedures.
- Conditions
- Bariatric Surgery Candidate, Covid19, Complication of Surgical Procedure, Pneumonia, Viral
- Trial name
- NCT04480034
- Testing
- Bariatric procedures
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- University of Roma La Sapienza
SARS-CoV 2, COVID-19
Test and Treat COVID 65plus+
Patients over equal or older than 65 yearswill be treated with a hydroxychloroquine versus placebo reduced loading dose of 600mg on the first day followed with 400mg/day divided in 2x200mg for 6 more days resulting in a total…
- Trial name
- COVID65plus (NCT04351516)
- Testing
- Hydroxychloroquine
- Where
- 2 sites in Germany
- Sponsor
- University Hospital Tuebingen
SARS-CoV-2
A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)
The purpose of this study is to evaluate the efficacy and safety of mRNA-1283 and mRNA-1273 (variant formulations) in adults 50 to 64 years of age without high risk factors for severe COVID-19.
- Trial name
- NCT07266558
- Testing
- mRNA-1273, mRNA-1283
- Where
- 150 sites in United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Corona Virus Infection, Thromboembolic Disease
Thrombosis Risk Assessment and Clinical Presentation of Covid-19 Pneumonia
Covid-19 mainly affects the respiratory system. Multiple organ dysfunction and a particularly progressive respiratory insufficiency along with a widespread coagulopathy presumed to be due to infection-associated inflammation and…
- Trial name
- Covid-19 (NCT04423315)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Nisantasi University
Diabetes, Covid19
Diabetes Outcomes in COVID-19 Pandemic
Diabetes management and follow-up has become a challenge during the COVID-19 pandemic. Nation-wide lockdowns and social distancing measures adopted in an attempt to break the chain of COVID-19 transmission have significantly…
- Conditions
- Diabetes, Covid19, Isolation, Social
- Trial name
- NCT04573335
- Where
- Pakistan
- Volunteers
- 1,282 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Pneumonitis, Coronavirus Infection
Proflaxis Using Hydroxychloroquine Plus Vitamins-Zinc During COVID-19 Pandemia
Healthcare professionals mainly doctors, nurses and their first degree relatives (spouse, father, mother, sister, brother, child) who have been started hydroxychloroquine(plaquenil) 200mg single dose repeated every three weeks…
- Trial name
- NCT04326725
- Testing
- Plaquenil 200Mg Tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istinye University
Covid19, Breathing Exercise
The Effect of Home-based Exercise on Functional Capacity of Covid-19 Survivor With Cardiovascular Comorbidity
Objective propose: to investigate the effect of home based breathing exercise and chest mobilization on the cardiorespiratory functional capacity of Covid-19 survivors with cardiovascular comorbidity.
- Conditions
- Covid19, Breathing Exercise, Cardiovascular Diseases
- Trial name
- NCT05077943
- Testing
- Breathing and chest mobilization exercises, Second phase cardiac rehabilitation
- Where
- Indonesia
- Volunteers
- 46 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
COVID-19
Heterologous Booster Study of COVID-19 Protein Subunit Recombinant Vaccine in Children 12-17 Years of Age
The goal of this clinical trial is to evaluate immune response and safety of SARS-CoV-2 subunit protein recombinant vaccine (IndoVac) as a heterologous booster dose in healthy children 12-17 years of age.
- Trial name
- NCT05727215
- Testing
- SARS-CoV-2 subunit protein recombinant vaccine
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- PT Bio Farma
Covid19, Pulmonary Embolism
Pulmonary Optical Coherence Tomography in COVID-19 Patients
To evaluate by intravascular OCT study the presence of microvascular pulmonary thrombosis in patients with COVID-19, high D-dimer levels and contrast CT scan negative for pulmonary thrombosis.
- Trial name
- NCT04410549
- Testing
- Optical Coherence Tomography (OCT)
- Where
- 2 sites in Brazil, Italy
- Volunteers
- 13 people
- Sponsor
- IRCCS San Raffaele
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