Clinical trials: Covid19 Immunology
COVID-19 Pandemics, Human Immunodeficiency Virus
The Impact Evaluation of the COVID-19 Prevention on Risk Factors of HIV and Sexually Transmitted Comorbidity
This is a cross-sectional research. The Protection Motivation Theory (PMT) was applied as theoretical framework to analyze correlation of prevention knowledge, prevention intentions and anxiety, and prevention behavior of…
- Trial name
- NCT05188456
- Where
- Taiwan
- Volunteers
- 2,200 people
- Sponsor
- National Taiwan University
Rheumatic Disease, HIV Infections
COVID-19 CoronaVac in Patients With Autoimmune Rheumatic Diseases and HIV/AIDS
Patients with chronic rheumatic diseases (such as systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], ankylosing spondylitis [AS], juvenile idiopathic arthritis [JIA], poly/dermatomyositis [PM/DM], systemic sclerosis…
- Conditions
- Rheumatic Disease, HIV Infections, AIDS, Safety Issues
- Trial name
- CoronavRheum (NCT04754698)
- Testing
- CoronaVac
- Where
- Brazil
- Volunteers
- 2,196 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
HIV Infections
Immunogenicity of COVID-19 Vaccination in PLWH
Various facts support the study of COVID-19 vaccine immunogenicity in People Living With HIV (PLWH) at this time: (1) Many PLWH in Canada will be eligible to receive COVID-19 vaccination as they are in a high priority risk group…
- Trial name
- HIV-COV (NCT04894448)
- Testing
- COVID-19 Vaccine
- Where
- 3 sites in Canada
- Volunteers
- 500 people
- Sponsor
- CIHR Canadian HIV Trials Network
SARS-CoV-2, Covid19
COVID-19 Child Health Investigation of Latent Disease in Hamburg
The study measures infection rates and the presence of antibodies for SARS-CoV-2 (COVID-19) among in- and outpatients of all pediatric hospitals, as well as volunteers aged 0 to 18 years in Hamburg, Germany.
- Trial name
- C19CHILD (NCT04534608)
- Where
- Germany
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
COVID-19 Stress Syndrome, COVID-19 Vaccine Adverse Reaction
COVID-19 Vaccination Detoxification in LDL-C
The study hypothesizes that SARS-CoV-2 vaccination poisoning hibernates in human host in Low Density Lipoprotein Cholesterol (LDL-C). The clinical trial is a follow-up from the intervention trial with NCT number NCT05711810.
- Conditions
- COVID-19 Stress Syndrome, COVID-19 Vaccine Adverse Reaction, COVID-19-Associated Thromboembolism, COVID-19 Post-Intensive Care Syndrome
- Trial name
- NCT05839236
- Testing
- Atorvastatin Calcium Tablets
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yang I. Pachankis
COVID-19
Phase I Study to Assess the Safety and Immunology of a COVID-19 Vaccine With GRAd-COV2 Vaccine
RT-CoV-2 is a Phase I, open-label, dose escalation multicenter clinical trial to assess safety and immunogenicity of the candidate Coronavirus disease (COVID-19) vaccine GRAd-COV2 in Italian healthy volunteers aged 18-55 years…
- Trial name
- NCT04528641
- Testing
- GRAd-COV2
- Where
- 2 sites in Italy
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- ReiThera Srl
Sexually Transmitted Infections (Not HIV or Hepatitis), HIV Infections
Overcoming Geography With Technology: Medical Drones Project
In this study, the investigators shall evaluate the use unmanned air vehicles (medical drones) to deliver ART to adult patients eligible/enrolled in community DSD models in Bufumira Islands, Kalangala district.
- Conditions
- Sexually Transmitted Infections (Not HIV or Hepatitis), HIV Infections, COVID-19
- Trial name
- NCT05259761
- Testing
- Unmanned ariel vehicle
- Where
- Uganda
- Volunteers
- 1,450 people, healthy volunteers welcome
- Sponsor
- Makerere University
Covid19
COVID-19 Immunologic Antiviral Therapy With Omalizumab
To evaluate if omalizumab is effective in decreasing mortality in severe hospitalized COVID-19 cases.
- Trial name
- CIAO (NCT04720612)
- Testing
- Omalizumab
- Where
- 3 sites in Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
HIV/AIDS, COVID-19
COVID-19 in Patients With HIV
Currently, limited data is available about patients with HIV in the context of the COVID-19 pandemic. People with HIV who have not achieved viral suppression through antiretroviral treatment may have a compromised immune system…
- Conditions
- HIV/AIDS, COVID-19, SARS-CoV-2
- Trial name
- NCT04333953
- Testing
- No intervention
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- University of Missouri-Columbia
Hiv, Depression in Old Age
Creating a Virtual Village for People Aging With HIV During COVID-19
In a PCORI-funded project on HIV and aging engagement that was co-led by the study team, the topics of isolation and depressions were identified as priority areas of deep concern among older PLWH.
- Conditions
- Hiv, Depression in Old Age, Isolation, Social, Aging
- Trial name
- NCT04747756
- Testing
- Virtual Village
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Covid19, Pregnancy Related
Clinical and Immunologic Impact of Perinatal SARS-CoV-2 (COVID-19) Infection
This is a multi-center prospective study that aims to investigate the clinical and immunologic impact of SARS-CoV-2 infection in pregnant women and neonates.
- Conditions
- Covid19, Pregnancy Related, Neonatal Infection
- Trial name
- NCT04362956
- Where
- Argentina
- Volunteers
- 114 people
- Sponsor
- Fundacion Infant
Covid-19, Health Personnel
Seroconversion Among Staff at a Large Acute Care Hospital in Denmark During the COVID-19 Pandemic
The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies in samples collected from HCWs in an acute hospital.
- Conditions
- Covid-19, Health Personnel, Personnel, Hospital
- Trial name
- NCT04431310
- Testing
- Serial seroconversion measurements in hospital employees during the COVID-19 pandemic
- Where
- 2 sites in Denmark
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
COVID-19 Vaccines
Randomized, Single-blinded, Multicenter Trial Comparing the Immune Response to a 2nd Booster Dose of COVID-19 mRNA Vaccine (Pfizer-BioNTech) or Sanofi /GSK B.1.351 Adjuvanted Vaccine in Adults
The effectiveness of COVID-19 vaccines in reducing the risk of severe COVID-19 is currently demonstrated. In France, since the beginning of the vaccination campaign, 54,266,859 people have received at least one injection (ie.
- Trial name
- COVIBOOSTAnci1 (NCT05405283)
- Testing
- 2nd booster with Comirnaty® (Pfizer-BioNTech), CoV2 preS dTM adjuvanted vaccine (B.1.351), Sanofi/GSK
- Where
- France
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis, COVID-19
Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19
Tuberculosis (TB) is now the commonest cause of death in many African countries. Globally, ~35% (almost 1 in 3) of TB cases are 'missed' (remain undiagnosed or undetected).
- Conditions
- Tuberculosis, COVID-19, HIV Infections
- Trial name
- NCT05220163
- Testing
- CAD, Xpert
- Where
- 3 sites in South Africa, Zambia and 1 more
- Volunteers
- 26,200 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
SARS-CoV-2 Infection, HIV Infections
Efficacy Study of COVID-19 mRNA Vaccine in Regions With SARS-CoV-2 Variants of Concern
The study will evaluate the clinical efficacy of different dosing regimens of the Moderna COVID-19 mRNA vaccine (100 mcg) in preventing COVID-19 disease in people who are living with HIV or have comorbidities associated with…
- Conditions
- SARS-CoV-2 Infection, HIV Infections, COVID-19
- Trial name
- CoVPN3008 (NCT05168813)
- Testing
- Moderna mRNA-1273, Moderna mRNA-1273.222, Vaccine 3 Dose
- Where
- 47 sites in Botswana, Eswatini and 5 more
- Volunteers
- 14,237 people
- Sponsor
- COVID-19 Prevention Network
Immunodeficiency, Immunosuppression
ImmunoCARE: Rapid, Accurate COVID Testing to Reduce Hospitalization of Immunocompromised Individuals
The investigators will examine whether a combination of at-home nucleic acid amplification tests, on-demand telemedicine, and delivery of prescriptions such as Paxlovid quickly after testing positive for COVID-19, can reduce…
- Conditions
- Immunodeficiency, Immunosuppression, HIV Infections, Graft Versus Host Disease
- Trial name
- NCT05655546
- Testing
- Access to Cue Health COVID-19 Remote testing and treatment for COVID-19
- Where
- United States
- Volunteers
- 2,117 people
- Sponsor
- Scripps Translational Science Institute
HIV Infections
Vaccines in a Time of Dual Pandemic: COVID-19 Vaccine in People With HIV
This is a prospective, non-randomized observational study to examine SARS-CoV-2 vaccine immunogenicity, immune activation and HIV reservoirs in people with HIV infection in comparison with HIV-negative individuals, in those aged…
- Trial name
- NCT06731127
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Covid19, SARS-CoV Infection
A Registry Study of COVID-19 Serologic and Virologic Testing to Accelerate Recovery and Transition
The co-primary objectives of this study are to: 1. Determine and compare the COVID-19 antibody positivity rate in health care workers and patients without a known COVID-19 infection 2.
- Trial name
- START (NCT04573634)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jill M Kolesar
Immunologic Activity Alteration
Asymptomatic COVID-19 Infection Among Healthcare Workers
To assess the seroprevalence of SARS-CoV-2 IgG in Health care workers in three University Hospitals
- Trial name
- NCT04354792
- Testing
- Serum SARs COV 2 IGg screening in health care workers
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
SARS-CoV Infection, Immune System Disorder
Co-Sér: Serological Analysis and Viral Neutralization in People With a Documented COVID-19 Infection
In light of the current coronavirus disease 2019 (COVID-19) pandemic, the investigators want to better study the immunological characteristics of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) infections in adults.
- Trial name
- Coser (NCT05000307)
- Testing
- Blood sample
- Where
- Belgium
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent