Clinical trials: Covid19- Coronavirus- Sars-cov-2
Post-COVID Condition, Long COVID
Long-Term Health Effects of Previous Coronavirus Disease 2019 (COVID-19) in Patients Undergoing Preoperative Anesthesia Evaluation
The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in persistent health problems in a significant proportion of individuals after recovery from the acute infection.
- Conditions
- Post-COVID Condition, Long COVID, Sequelae of COVID-19
- Trial name
- NCT07435805
- Testing
- Post-COVID Clinical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
SARS-CoV-2 Infection, COVID-19
A Study to Evaluate the Immunogenicity and Safety of a Recombinant Protein COVID-19 Vaccine in Population Aged ≥18 Years
The study is a randomized, double-blind, positive-controlled Phase II booster study. It will evaluate the immunogenicity and safety of SCTV01E compared with Comirnaty.
- Trial name
- NCT05329051
- Testing
- SCTV01E, Comirnaty
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sinocelltech Ltd.
Preventive Immunization COVID-19
An Open Study of the Safety, Tolerability and Immunogenicity of "Gam-COVID-Vac Lyo" Vaccine Against COVID-19
the purpose of this study: to evaluate the safety, tolerability and immunogenicity of the drug "Gam-COVID-Vac Lyo", a lyofilizate for preparing solution for intramuscular administration, at various times after vaccination in…
- Trial name
- NCT04437875
- Testing
- Gam-COVID-Vac Lyo
- Where
- Russia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
SARS-CoV Infection, Covid19
Study of SARS-CoV2 Virus (COVID-19) Seroprevalence Among Lyon-Bron Military Health Schools Personnel
Emerging in China in December 2019, Covid-19, whose pathogen is SARS-Cov-2, was declared a global pandemic in March 2020. The clinical presentation is highly variable, ranging from asymptomatic forms to acute respiratory distress…
- Trial name
- SeroCovEms (NCT04516928)
- Testing
- Anti-SARS-CoV2 Serology, Questionnaire
- Where
- France
- Volunteers
- 392 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
NSCLC Stage IV, HIV
Nivolumab/Ipilimumab and Chemotherapy Combination in Advanced NSCLC Patients With HIV, HBV, HCV and Long Covid Syndrome
Study type: Phase 2 - Interventional Trial Number of patients to be enrolled: 105 Participating countries: Italy Study drugs: nivolumab and ipilimumab Cohort A: HBV and HCV patients Cohort B: HIV patients Cohort C: Long COVID…
- Conditions
- NSCLC Stage IV, HIV, HBV, HCV
- Trial name
- LUNGVIR (NCT05597800)
- Testing
- Nivolumab and Ipilimumab
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- Universita di Verona
Covid-19, Cancer
COVID-19 in Pediatric Oncology and Hematology Centers in France
Since the description of the first cases of infection in December 2019 in the Hubei province in China, a new coronavirus, called SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), emerged and caused a pandemic.
- Trial name
- PEDONCOVID (NCT04433871)
- Testing
- No intervention, observational
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Covid19
The Prevent Severe COVID-19 (PRESECO) Study
Double-blinded, placebo control, randomized, phase-3 clinical trial to evaluate clinical efficacy of Favipiravir in patients with mild to moderate symptoms related to COVID-19 infection
- Trial name
- PRESECO (NCT04600895)
- Testing
- Favipiravir
- Where
- 38 sites in United States, Brazil and 1 more
- Volunteers
- 1,187 people
- Sponsor
- Appili Therapeutics Inc.
Covid-19
Retrospective Study on Anosmias and Ageusias Linked to Infection by Covid-19
Odor and taste disturbances have increased dramatically during this time of the COVID-19 pandemic. Currently, we have very little information on the demographic and clinical characteristics of the affected population, on the…
- Trial name
- STras-Cov-2 (NCT04681157)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Dyspnea Caused by 2019-nCoV
Bevacizumab in Post-acute Sequelae of COVID-19 : Efficacy and Safety (Pilot Study)
The aim of this research is to evaluate an innovative treatment, Bevacizumab, in patients suffering from respiratory complications related to COVID-19.
- Trial name
- BASECOVID (NCT07089719)
- Testing
- Bevacizumab Injection
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronavirus COVID-19, Respiratory Infection
EEG as Predictor of HD-tDCS Effectiveness in Long COVID-19
COVID-19 is an infectious disease which presents a heterogenous clinical presentation. Recent investigations suggest that people who were infected by COVID-19 often develop physical disabilities (i.e.
- Trial name
- NCT05289128
- Testing
- Experimental group
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Paraíba
COVID-19
Proof of Concept Study to Evaluate the Safety Profile of Plitidepsin in Patients With COVID-19
In December 2019, Wuhan, in Hubei province, China, became the center of an outbreak of pneumonia of unknown cause. In a short time, Chinese scientists had shared the genome information of a novel coronavirus (SARS-CoV-2) from…
- Trial name
- APLICOV-PC (NCT04382066)
- Testing
- Plitidepsin 1.5 mg/day, Plitidepsin 2.0 mg/day, Plitidepsin 2.5 mg/day
- Where
- 13 sites in Spain
- Volunteers
- 46 people
- Sponsor
- PharmaMar
COVID-19, Comorbidities and Coexisting Conditions
Telerehabilitation in Patients With COVID-19 After Hospitalization. The ATHLOS Study
This is a two-phase multicenter study that will be conducted in collaboration with five university hospitals, in order to offer telehealth services at home in patients with COVID-19, after hospital discharge.
- Trial name
- ATHLOS (NCT04368845)
- Testing
- Telerehabilitation
- Where
- Greece
- Volunteers
- 82 people
- Sponsor
- University of Thessaly
Pneumonia
Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia
This research study is being done to determine the appropriate dose of steroids and the appropriate duration for steroid use to reduce inflammation in severe pneumonia needing a form of breathing support.
- Trial name
- NCT03852537
- Testing
- Methylprednisolone, Usual Care
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Mayo Clinic
History of Cardiovascular Disease Treated With RAS Blockers and With SARS-CoV-2 Infection
ACE Inhibitors or ARBs Discontinuation in Context of COVID-19 Pandemic
Since December 2019, a novel coronavirus called SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has caused an international outbreak of respiratory illness described as COVID-19.
- Trial name
- ACORES-2 (NCT04329195)
- Testing
- 1: discontinuation of RAS blocker therapy, 2: continuation of RAS blocker therapy
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID
A Research Study to Evaluate the Benefits of a Self-management Booklet to Promote Wellbeing During the COVID-19 Pandemic
Background The immediate psychological impact of COVID-19 is already emerging. The investigators are interested in the benefits of a self-management booklet focused on the current circumstances in response to the COVID-19…
- Trial name
- SWitCh (NCT04408157)
- Testing
- Self-management booklet (SWitCh: Stay well during COVID-19)
- Where
- United Kingdom
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- King's College London
COVID-19, SARS-CoV-2 Acute Respiratory Disease
Safety, Tolerability and Immunogenicity of Gam-COVID-Vac Vaccine in a Nasal Spray
Randomized, double-blind, placebo-controlled trial to evaluate safety and immunogenicity of intranasal "Gam-COVID-Vak" combined vector vaccine for the prevention of coronavirus infection caused by the SARS-CoV-2 virus.
- Trial name
- SPRAY (NCT05248373)
- Testing
- Gam-COVID-Vac
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
COVID-19 Respiratory Infection, SARS CoV 2 Infection
Pancoronavirus Vaccine Study in Healthy Adults
Coronaviruses (CoVs) have caused the severe acute respiratory syndrome (SARS) outbreak, the Middle East Respiratory Syndrome (MERS) outbreak, and now the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
- Conditions
- COVID-19 Respiratory Infection, SARS CoV 2 Infection, COVID-19 Vaccine
- Trial name
- NCT06950177
- Testing
- CoV-RBD-scNP-001 and 3M-052-AF
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Duke University
Vaccine Adverse Reaction, COVID-19
Immunization of 7 Different Vaccines Against SARS-COV-2 Across 4 Countries.
Background: Scarce information exists in relation to the comparison of seroconversion and adverse events following immunization (AEFI) with different SARS-COV2 vaccines.
- Conditions
- Vaccine Adverse Reaction, COVID-19, Vaccine Reaction
- Trial name
- NCT05228912
- Testing
- COVID-19 Vaccines
- Where
- Mexico
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- Hospital Clinica Nova
COVID-19
Dysbiosis & Long COVID
The SARS-CoV-2 virus causes COVID-19, which ranges from mild initial symptoms to severe multi-organ dysfunction. While some patients recover to their baseline states, others develop a long COVID, or post-acute sequelae of…
- Trial name
- NCT06825819
- Testing
- Subjects with and without Long COVID
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Chicago
SARS-CoV-2 Infection, COVID-19
A Study to Evaluate Safety, Tolerability, & Immunogenicity of Multiple Formulations of BNT162b2 Against COVID-19 in Healthy Adults
This study will compare the safety and tolerability of lyophilized BNT162b2 presented in single dose vials to those of frozen-liquid BNT162b2 in multidose vials and determine whether the immune response is noninferior.
- Trial name
- NCT04816669
- Testing
- BNT162b2
- Where
- 21 sites in United States
- Volunteers
- 629 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
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