Clinical trials: Cow Milk Intolerance
Cow's Milk Allergy, Intolerance to Extensively Hydrolyzed Formulas
Evaluation of Fatty Acid Levels and Growth in Infants Fed Amino Acid Based (AA) Formulas
This clinical trial will compare the amount of fatty acids in whole blood of babies fed one of two study formulas for 4 months.
- Conditions
- Cow's Milk Allergy, Intolerance to Extensively Hydrolyzed Formulas, Intolerance to Breast Milk
- Trial name
- NCT01470768
- Testing
- Amino Acid-based Formula with high DHA and ARA, Amino Acid-based Formula with lower DHA and ARA
- Where
- United Kingdom
- Sponsor
- Mead Johnson Nutrition
Prematurity
Lactase-Assisted Control Trial On Weight GAin in INfants.
Lactose, a disaccharide that includes the monosaccharides glucose and galactose, is the main carbohydrate found exclusively in mammalian milk.
- Trial name
- LACTOGAIN (NCT07150884)
- Testing
- Lactase
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Lactose Intolerance
Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance
RP-G28 is being investigated for treatment of moderate to severe lactose intolerance and its potential to improve the tolerance of lactose (dairy products).
- Trial name
- NCT02673749
- Testing
- RP-G28
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Ritter Pharmaceuticals, Inc.
Milk Hypersensitivity, Food Sensitivity
Evaluation of the Efficacy of a New Formula in Infants With Cow's Milk Protein Allergy
The aim of the study is to show the efficacy, tolerance and nutritional adequacy of a newly developed hydrolyzed rice formula in infants with a proven cow's milk protein allergy.
- Conditions
- Milk Hypersensitivity, Food Sensitivity, Protein Allergy
- Trial name
- Paradice (NCT01998074)
- Testing
- extensively hydrolyzed rice protein formula
- Where
- Belgium
- Sponsor
- United Pharmaceuticals
Gastrointestinal Diseases, Cow's Milk Intolerance
Goat Milk Infant Formula Comfort Study
In this study, the investigators aim to assess that infants with mild symptoms have significantly less (severe) symptoms after 14 days goat milk-based formula use compared to infants using cow's milk-based formula supplemented…
- Trial name
- NCT06301139
- Testing
- Goat milk-based infant formula, Cow's milk-based infant formula with probiotic drops
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ausnutria Hyproca B.V.
Lactose Intolerance, Adult Type
Comparing the Gastric Transit of Commercial Milk and A2 Milk
Cow's milk contains two types of β-casein: A1 and A2. The μ-opioid peptide BCM-7 is released from A1 but not from A2. BCM-7 is associated with slower gastrointestinal transit and hence increased gastrointestinal transit times.
- Trial name
- NCT05658861
- Testing
- Milk containing A1 and A2 beta-casein, Milk containing only A2 beta-casein
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Purdue University
Pre-Diabetes
Full-fat Yogurt and Glucose Tolerance
This study determines if substituting full-fat yogurt (i.e., whole, 3.25% fat) for non-fat yogurt in the diet can reduce the risk of type 2 diabetes and inflammation in association with changes in the composition of the…
- Trial name
- NCT03577119
- Testing
- Full-fat yogurt, Non-fat yogurt
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Human Milk Fortification, Very Low Birth Weight Baby
Enrichment of Human Milk With Human and Bovine Milk-based Fortifiers for Very Preterm Infants: a Meta-analysis
Research has shown that provision of mother's milk is the optimal way to feed very low birthweight (VLBW) infants. Many infants will require a supplement to mother's milk, pasteurized donor human milk (PDHM) compared to preterm…
- Conditions
- Human Milk Fortification, Very Low Birth Weight Baby, Human Milk Nutrition, Human Milk Feeding
- Trial name
- NCT06870318
- Testing
- No intervention; Observational study
- Where
- 2 sites in Canada, Sweden
- Volunteers
- 355 people
- Sponsor
- The Hospital for Sick Children
Premature; Infant, Light-for-dates
Re-feeding Gastric Residuals in Preterm Infants
The purpose of this study is to determine whether re-feeding of gastric residuals reduces the time needed to establish full enteral feedings in premature infants.
- Trial name
- NCT01420263
- Testing
- Re-feeding residuals, Fresh Feeding Breastmilk or Formula only
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Alabama at Birmingham
Growth, Necrotizing Enterocolitis
Bovine Colostrum as a Fortifier Added to Human Milk for Preterm Infants
Very preterm infants (<32 weeks gestation) with very low birth weight (VLBW, <1500 g) show immaturity of organs and have high nutrient requirements forgrowth and development.
- Conditions
- Growth, Necrotizing Enterocolitis, Late-Onset Sepsis, Feeding Intolerance
- Trial name
- FortiColos (NCT03537365)
- Testing
- Bovine Colostrum (BC) / intervention group, FM85 / control group
- Where
- 7 sites in Denmark
- Volunteers
- 252 people
- Sponsor
- Per Torp Sangild
Lactose Intolerants, Lactose Malabsorption
Milk Beta Caseins on Digestive Discomfort, Gastric Emptying
A1 and A2 β-casein are genetic variants of β-casein in cow's milk that differ by a single amino acid at position 67. Digestion of A1 β-casein may result in greater release of beta-casomorphin-7 (BCM-7), an opioid peptide that may…
- Conditions
- Lactose Intolerants, Lactose Malabsorption, Caseins
- Trial name
- Oral Naloxone (NCT07884123)
- Testing
- A1/A2 milk with oral naloxone, A1PF milk with oral naloxone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Purdue University
Protein Intolerance
A2 GUM Post-Market Effectiveness Study
This is a post-market, real-life effectiveness study of A2 growing up milk on toddlers' gut comfort.
- Trial name
- NCT03698058
- Testing
- Toddler milk
- Where
- China
- Volunteers
- 387 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Allergy
Althera® Versus Nutramigen / Cow's Milk Intolerance
The primary objective of this study is to demonstrate that ALTHERA® is equal or superior in efficacy than NUTRAMIGEN®
- Trial name
- NCT01727115
- Testing
- Infant Formula Feeding
- Where
- 14 sites in Belgium
- Volunteers
- 116 people
- Sponsor
- Société des Produits Nestlé (SPN)
Lactose Intolerance
Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose Maldigesters
Cow's milk contains two types of β-casein: A1 and A2. It is evident from human clinical trials that milk with A1 protein produces more hydrogen and symptoms of lactose intolerance.
- Trial name
- NCT05669274
- Testing
- Milk containing A1 and A2 beta-casein, Milk containing only A2 beta-casein
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue University
Breast Milk Protein Intolerance
Recruiting All Strictly Breast-fed Babies With Blood In Stool
Breast feeding is the most nutritious form of nourishment in infants and is recommended for at least the first four months of life. Breast fed infants may develop milk protein intolerance.
- Trial name
- NCT02745977
- Testing
- Dairy Free Diet
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Milk Intolerance
Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance
There is increasing evidence that a number of people experience moderate milk intolerance characterised by increased gas production, bloating and abdominal cramp, which can neither be attributed to lactose intolerance, nor to…
- Trial name
- NCT03060395
- Testing
- A2 milk 100, A2 milk 150, A2 milk 200
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cow's Milk Protein Allergy Protein Intolerance Failure to Thrive
Nutritional Evaluation of Infants Receiving Amino Acid-Based Formula
This study aims to evaluate the growth parameters and nutritional status of infants who are receiving amino acid-based formula due to cow's milk protein allergy or other medical indications.
- Trial name
- NCT07174999
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Assiut University
Pre Diabetes
Impact of Whey and Leucine on Glycaemia in Adults Without Diabetes
Higher than average blood sugar (glucose) levels are linked to an increased risk of developing type 2 diabetes. As such, there is interest in identifying dietary factors that could lower blood glucose to help reduce the number of…
- Trial name
- Whey2Glo (NCT03785951)
- Testing
- Whey Protein Isolate, Wheat Protein, Wheat Protein with Leucine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Reading
Dairy Intolerance, Healthy Adults
Double Crossover Casein Type Tolerance Trial
The investigators will recruit 45 fluid milk avoiding adults to participate in a five-week double-blind, double-crossover study in which the physiological responses to increasing doses of lactose-free (A1-rich milk), A2 milk, and…
- Trial name
- NCT06315517
- Testing
- Conventional lactose-free cow's milk, Nonconventional (A2) cow's milk, Nonconventional (A2) lactose-free cow's milk
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Auburn University
Low Milk Supply, Pre-diabetes
Metformin to Augment Low Milk Supply (MALMS) Study
Most new mothers in the United States will start off breastfeeding. For some mothers, despite following best practices, they are not able to meet their breastfeeding goals due to unexplained low milk supply.
- Conditions
- Low Milk Supply, Pre-diabetes, Insulin Resistance, Suppressed Lactation
- Trial name
- MALMS (NCT02179788)
- Testing
- Standard care, Metformin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati