Clinical trials: Craniectomy
Graft Versus Host Disease, Hyperkalemia
Irradiated Blood Versus Non Irradiated Blood Transfusions in Craniosynostosis Repair
Blood transfusions are required for patients undergoing a craniosynostosis repair due to the significant amount of blood loss. Irradiated or non-irradiated transfusions have many risks involved including elevated potassium levels…
- Conditions
- Graft Versus Host Disease, Hyperkalemia, Craniectomy, Synostectomy
- Trial name
- NCT02483702
- Testing
- Irradiated Blood Transfusions, Non-Irradiated Blood Transfusions
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Brain Edema, Craniocerebral Trauma
A Comparison Between Two Techniques for Performing Decompressive Craniectomy
The purpose of this study is to compare two surgical techniques for a neurosurgical procedure used to treat cerebral edema (decompressive craniectomy): with watertight duraplasty vs.
- Conditions
- Brain Edema, Craniocerebral Trauma, Infarction, Middle Cerebral Artery
- Trial name
- NCT02594137
- Testing
- Without watertight duraplasty
- Volunteers
- 58 people
- Sponsor
- Hospital of the Restoration, Recife
Epidural Hematoma, Brain Herniation
Prospective Randomized Evaluation of Decompressive Ipsilateral Craniectomy for Traumatic Acute Epidural Hematoma
Although craniotomy provides a more complete evacuation of the acute epidural hematoma, there are insufficient data to support specific surgical treatment method.
- Conditions
- Epidural Hematoma, Brain Herniation, Decompressive Craniectomy, Craniotomy
- Trial name
- PREDICT-AEDH (NCT04261673)
- Testing
- Decompressive Craniectomy, Craniotomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Chronic Subdural Hematoma
The Efficacy of the Longeviti ClearFit Implant in Craniectomies for Post-Operative Monitoring in Chronic Subdural Hematomas
Chronic subdural hematomas are frequent neurosurgical issues that are most often treated with burr hole craniectomies to drain the subdural fluid.
- Trial name
- NCT06127615
- Testing
- ClearFit
- Sponsor
- University of Kansas Medical Center
Cerebral Venous Thrombosis
Evaluation of Cerebral Oxygenation and Hemodynamics in Patients With Cerebral Venous Thrombosis
Cerebral hypoperfusion and hypoxia are the major determinants of neurological outcomes following acute brain injury as proved in Traumatic Brain Injury/Sub Arachnoid Haemhorrhage literature.
- Trial name
- NCT03033966
- Testing
- NIRS based Cerebral Oximetry
- Where
- India
- Volunteers
- 17 people
- Sponsor
- Dhritiman Chakrabarti
Craniotomy
Craniofacial Surgery Perioperative Registry
Craniofacial reconstruction procedures are undertaken in young children to improve appearance, prevent functional disturbances, and enhance psychosocial development.
- Trial name
- NCT00658242
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- Children's Hospital of Philadelphia
Decompressive Craniectomy and Cranioplasty
Predictive Factors for Cranioplasty Complications - A Decade Experience
This is a single-center, observational retrospective study. This study aims to identify predictive factors of complications for patients submitted to cranioplasty after decompressive craniectomy for all types of etiologies.
- Trial name
- NCT04791904
- Where
- Portugal
- Volunteers
- 168 people
- Sponsor
- Universidade do Porto
Craniectomy, Sugammadex
Comparison of the Effects of Sugammadex and Neostigmine on Early Extubation, Intensive Care Unit Admission and Length of Stay, and Hospital Costs in Adult Cranial Surgery
The aim of this study was to retrospectively investigate the effects of sugammadex or neostigmine, which are routinely used after the completion of surgery to antagonize (reverse) neuromuscular blockade in adult patients…
- Conditions
- Craniectomy, Sugammadex, Extubation, Recovery After Neuromuscular Block
- Trial name
- NCT06987357
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Brain Edema, TBI (Traumatic Brain Injury)
Dynamic Decompressive Craniotomy
Prospective observational study on patients undergoing decompressive craniotomy
- Conditions
- Brain Edema, TBI (Traumatic Brain Injury), Stroke, Acute, Cerebral Hemorrhage
- Trial name
- NCT05051488
- Testing
- Dynamic craniotomy
- Volunteers
- 20 people
- Sponsor
- Rohit Khanna, MD
Epidural Hematoma, Decompressive Craniectomy
Prospective, Observational Real-world Treatments of AEDH in Large-scale Surgical Cases
This is a multicenter, prospective, and observational real-world study aimed at investigating the current situation of surgical treatments and prognosis for acute epidural hematoma in China, and analyzing the optimization of…
- Conditions
- Epidural Hematoma, Decompressive Craniectomy, Craniotomy
- Trial name
- PORTALS-AEDH (NCT04229966)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- RenJi Hospital
Ischemic Stroke, Decompressive Craniectomy
Craniectomy Protocol
The objective of this protocol is to evaluate the quality of life and functional disability in the long term (2 years after craniectomy) in subject's victims of malignant Sylvien stroke who received a decompressive craniotomy in…
- Trial name
- NCT01990014
- Where
- 4 sites in France
- Volunteers
- 62 people
- Sponsor
- Nantes University Hospital
Brain Injuries, Stroke
Novel Head Protection Prototype Device for Decompression Craniectomy
A proof-of-concept (POC) proposal to study the feasibility of customized head protection prototype device (HPPD) using 3D printed externally-applied moulded skin prosthesis integrated to the craniectomy bony skull defect.
- Trial name
- HPPD (NCT04021095)
- Testing
- Head protection prototype device
- Where
- Singapore
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Acquired Brain Injury, Traumatic Brain Injury
Connectivity in Cranioplasty
An Exploratory Interventional study to assess the effects of cranioplasty on brain network connectivity, neuropsychological and motor functioning in patients with severe acquired brain injury with pre-, post-cranioplasty and 6…
- Conditions
- Acquired Brain Injury, Traumatic Brain Injury, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT05440682
- Testing
- CP group
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Azienda Usl di Bologna
Glioblastoma
Enhancing Optune Therapy With Targeted Craniectomy
The present study proposes a new and potentially superior clinical approach to Optune™ therapy of selected glioblastoma patients.
- Trial name
- NCT02893137
- Testing
- Optune, Craniectomy
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Aarhus University Hospital
Brain Injuries
The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury
This is a multi-centre randomised trial to evaluate the effect of early decompressive craniectomy on neurological function in patients with severe traumatic brain injury.
- Trial name
- NCT00155987
- Testing
- Early decompressive craniectomy
- Where
- Australia
- Volunteers
- 155 people
- Sponsor
- National Trauma Research Institute
Cognitive Impairment, Brain Herniation
Cranioplasty Cognitive Outcome Study
This will be a multicenter prospective randomized study of adult patients with an acquired skull defect as a result of craniectomy and considered suitable for cranioplasty, i.e.
- Trial name
- NCT03791996
- Testing
- "Early" cranioplasty
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Kwong Wah Hospital
Intracranial Pressure Increase
Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy.
This is a single centre, observational study with a medical device which has Conformité Européenne (CE) marking. The aim of the study is to demonstrate that patients with malignant middle cerebral artery infarction (M-MCA) show…
- Trial name
- NCT03221959
- Testing
- Medical Device Vittamed 205
- Volunteers
- 48 people
- Sponsor
- Kienzler Jenny
Trephined Syndrome, Sinking Skin Flap Syndrome
Prevalence of Trephined Syndrome After Decompressive Craniectomy
Decompressive craniectomy is frequently used to treat increased intracranial pressure or an intracranial mass effect. Trephined Syndrome describes a neurological deterioration, which is attributed to a large craniectomy.
- Conditions
- Trephined Syndrome, Sinking Skin Flap Syndrome, Traumatic Brain Injury, Stroke
- Trial name
- TS (NCT03186157)
- Testing
- Decompressive craniectomy, Cranioplasty
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- University Hospital, Geneva
Head Injuries, Subarachnoid Haemorrhage
Impact of Cranioplasty On Cerebral Perfusion
The purpose of this study is to examine the impact of cranioplasty on cerebral hemodynamic and blood flow as prognostic factor in patients receiving decompressive craniectomy for Head injuries, Subarachnoid haemorrhage…
- Conditions
- Head Injuries, Subarachnoid Haemorrhage, Intra-cerebral Haemorrhage, Cerebral Thrombosis
- Trial name
- CCP (NCT01113645)
- Testing
- Cerebral perfusion evaluation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Clinical Need for Craniotomy or Craniectomy, Clinical Need for Cranioplasty
A Multi-center, Early Feasibility Study of Using the Mechanical Tissue Resuscitation™ (MTR®) Therapy System for Removal of Excess Fluid in Subjects Who Have Had a Portion of Their Skull Removed to Expose the Dura/Brain and Require Drainage for Fluid Removal.
A multi-center, early feasibility study of using the Mechanical Tissue Resuscitation™ (MTR®) therapy system for removal of excess fluid in subjects who have had a portion of their skull removed to expose the dura/brain and…
- Trial name
- NCT06201429
- Testing
- Mechanical Tissue Resuscitation™ (MTR®)
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Renovo Concepts, Inc.