Clinical trials: Craniotomy
Craniotomy, Postoperative Complications
eCRANIO Trial Study on Elective CRAniotomies: Postoperative Neurointensive Care, Imaging and Outcome
Regarding the postoperative care strategies following elective craniotomy procedures there is little evidence. Many neurosurgical departments prefer these patients to remain intubated and sedated for many hours postoperatively to…
- Trial name
- eCRANIO (NCT01987648)
- Testing
- Elective Craniotomy Patients
- Where
- Switzerland
- Volunteers
- 1,969 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postoperative Nausea and Vomiting
Dexamethasone Palmitate for PONV After Craniotomy
Dexamethasone is almost one of the most commonly used drugs for postoperative nausea and vomiting (PONV) prevention. However, PONV is still a complex problem to be solved; for example, even with preoperative dexamethasone…
- Trial name
- NCT06988124
- Testing
- Dexamethasone Palmitate, Dexamethasone
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Melanoma, Brain Metastases
CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases
The purpose of this study is to collect and bank samples of blood and tissues (such as brain tissue or lymph nodes), as well as cerebrospinal fluid (CSF), which is the fluid that bathes and cushions the spinal cord.
- Trial name
- 13-052 (NCT02058953)
- Testing
- Craniotomy scheduled, Collection for non-craniotomy
- Where
- 3 sites in United States, Australia
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh
Postoperative Nausea and Vomiting
Effectiveness of Triple Therapy With Palonosetron for PON Prophylaxis
Postoperative nausea and vomiting (PONV) is a displeasing experience that distresses surgical patients during the first 24 hours after a surgical procedure.
- Trial name
- NCT02635828
- Testing
- Palonosetron 0.075 mg IV, Dexamethasone 10 mg IV, Promethazine 25 mg IV
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Craniotomy
Efficacy of Scalp Block on Hemodynamic Stability and Opioid Consumption During Craniotomy
Prospective randomised double-blinded placebo-controlled trial on the efficacy of scalp blocks on hemodynamic stability and opioid consumption during and after craniotomy.
- Trial name
- NCT02880566
- Testing
- Scalp block
- Volunteers
- 50 people
- Sponsor
- University of Liege
Chronic Subdural Hematoma, cSDH
Prospective Multi-center Single Arm Study for Subjects With Chronic Subdural Hematoma Treated With i-ED COILs, Either Alone or in Combination With Burr-holes or Mini-craniotomy
All participants will be asked to have a minimally invasive procedure for the treatment of chronic subdural hematoma, a blood clot on the brain.
- Conditions
- Chronic Subdural Hematoma, cSDH, Chronic Subdural Hematomas
- Trial name
- iCURE cSDH (NCT07214623)
- Testing
- Neuro endovascular embolic coil
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Kaneka Medical America LLC
Patients Undergoing Elective Craniotomy
Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery
Since neurological testing during neurosurgery, such as somato-sensory evoked potentials, motor-evoked potentials, auditory evoked potentials and visual evoked potentials are well maintained their wave-form reactivity with total…
- Trial name
- NCT01985854
- Testing
- Propofol, Desflurane
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Tokyo Women's Medical University
Postoperative Pain, Lidocaine
Pre-emptive Topical Lidocaine 5% Plaster for Prevention of Post-craniotomy Pain
Postcraniotomy pain remains a common phenomenon in the neurosurgery field. Managements for postcraniotomy pain are to be standardised and optimized.
- Trial name
- EASY (NCT04169854)
- Testing
- Lidocaine 5% patch
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing Tiantan Hospital
Brain Tumor, Bleeding
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
The goal of this clinical trial is to test the effect of a drug called tranexamic acid (TXA) on reducing blood loss in participants undergoing surgery to remove brain tumors. The main questions it aims to answer are: 1.
- Trial name
- NCT06229483
- Testing
- TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Stephen Lownie
Hyperglycemia, Craniotomy
Impact of Severe Intraoperative Hyperglycemia on Infection Rate After Elective Intracranial Interventions
Severe intraoperative hyperglycemia (SIH) is recognized as one of the important risk factors for the increasing of the postoperative infections rate, which can negatively affect the final outcome of surgical treatment.
- Conditions
- Hyperglycemia, Craniotomy, Infection Post Op
- Trial name
- NCT04285359
- Testing
- Intracranial Interventions
- Where
- 2 sites in Italy, Russia
- Volunteers
- 514 people
- Sponsor
- Burdenko Neurosurgery Institute
Postoperative Nausea and Vomiting
Scalp Blocks Effect on Postoperative Nausea & Vomiting After Craniotomy
In this study, the investigators hypothesize that preemptive scalp block in neurosurgical patients may decrease incidence of PONV after craniotomy through decreasing intraoperative inhalational agents' concentration and…
- Trial name
- NCT04240236
- Testing
- Scalp block, Control Group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Supratentorial Brain Tumor
Comparison of the Effect of Low and High Fraction of Inspired Oxygen on Postoperative Surgical Field Infection
The purpose of this study is to compare the effect of high 0.8 and low 0.4 *FiO2 ventilation primarily on surgical field infection and secondarily on postoperative pulmonary complications in patients are undergoing supratentorial…
- Trial name
- NCT03454659
- Testing
- Craniotomy
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Perioperative Hypertension
Evaluation of Periop Biochemical Stress Factors in Craniotomy Neurosurgical Procedure With Respect to Preop Hypertension
Perioperative hypertension is commonly associated with surgical craniotomy. As the sympathetic nervous system and the renin-angiotensin-aldosterone system play a key role in the development of this hypertension, preoperative…
- Trial name
- NCT02441842
- Testing
- atenolol, lisinopril, glucose
- Volunteers
- 85 people
- Sponsor
- Milton S. Hershey Medical Center
Infratentorial Neoplasms, Hyperventilation
The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery
The aim of this study is to evaluate the changes of cerebral oxygen saturation during hyperventilation and normo-ventilation (using near-infrared spectroscopy) in pediatrics undergoing posterior fossa tumor resection.
- Conditions
- Infratentorial Neoplasms, Hyperventilation, Craniotomy
- Trial name
- NCT04232059
- Testing
- cerebral oximetry
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Kasr El Aini Hospital
Craniotomy, Seizures
Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
Awake craniotomy require a cooperative patient during resection neurosurgery phase. Anesthesiologist should guarantee analgesia, sedation, nausea and vomiting prevention, while maintaining normal vital parameters.
- Conditions
- Craniotomy, Seizures, Dexmedetomidine, Propofol
- Trial name
- NCT05103735
- Testing
- Propofol
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Infection, Surgery
Topical Vancomycin for Neurosurgery Wound Prophylaxis
This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures.
- Conditions
- Infection, Surgery, Nervous System Diseases
- Trial name
- Vanguard (NCT02284126)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 1,103 people
- Sponsor
- Columbia University
Glioblastoma, IDH-wildtype, Glioblastoma
The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma
Resection of glioblastoma in or near functional brain tissue is challenging because of the proximity of important structures to the tumor site.
- Conditions
- Glioblastoma, IDH-wildtype, Glioblastoma, Glioblastoma Multiforme of Brain, Astrocytoma, Malignant
- Trial name
- RECMAP (NCT06273176)
- Testing
- Awake mapping under local anesthesia, Asleep mapping under general anesthesia, Resection under general anesthesia without mapping
- Where
- 8 sites in United States, Belgium and 3 more
- Volunteers
- 225 people
- Sponsor
- Erasmus Medical Center
Anesthesia, Craniotomy
Anesthesiological Strategies in Elective Craniotomy
This protocol, NeuroMorfeo, aims to assess equivalence between volatile and intravenous anesthetics for neurosurgical procedures.
- Conditions
- Anesthesia, Craniotomy, Neurosurgery
- Trial name
- Neuromorfeo (NCT00741351)
- Testing
- Sevoflurane + Fentanyl, Sevoflurane + Remifentanyl, Propofol + Remifentanyl
- Where
- 15 sites in Italy
- Volunteers
- 411 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Pain, Postoperative, Post-Craniotomy Headache
Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Postoperative Pain After Craniotomy
A majority of patients would suffer from moderate-to-severe postoperative pain after undergoing craniotomy. As a result, adequate pain control is essential for patients' prognosis and their postoperative life quality.
- Trial name
- NCT03618264
- Testing
- Miscible liquid of dexamethasone and ropivacaine, Ropivacaine
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Pain
Intravenous Acetaminophen in Craniotomy
The purpose of this study is to assess the use of intravenous Acetaminophen (OFIRMEV) as an effective adjunct therapeutic agent in patients undergoing craniotomy.
- Trial name
- NCT01598701
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston