Clinical trials: Creatine
Osteoporosis, Sarcopenia
Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone
As we age, we experience a reduction in muscle and bone which inevitably decreases strength and the ability to perform tasks of daily living such as gardening, carrying groceries, and climbing stairs.
- Trial name
- NCT01057680
- Testing
- creatine monohydrate
- Where
- 2 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Post-partum, Women
Creatine for Recovery and Thinking in Mothers
The purpose of this randomized, double-blind, parallel-group trial is to compare the effects of two doses of creatine monohydrate (5 g/day versus 10 g/day) administered for four weeks in postpartum women.
- Trial name
- CREATE-MOM (NCT07795853)
- Testing
- Creatine Monohdyrate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Pelvic Floor; Rupture, Old (Postpartum)
Correlation Between Creatine Phosphokinase and Pelvic Floor Muscle Strength in Postnatal Women
The purpose of this study is to determine the correlation between creatine phosphokinase and pelvic floor muscle strength in post-partum women.
- Trial name
- NCT06502392
- Testing
- Assessment of creatine phosphokinase, Assessment of pelvic floor muscle strength
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Cairo University
Amyotrophic Lateral Sclerosis
Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis
The objective of this study is to compare two combinations of drugs, minocycline and creatine or celecoxib and creatine, in a phase II trial designed to determine which combination is more effective for ALS.
- Trial name
- NCT00355576
- Testing
- Celecoxib, Creatine, Minocycline
- Where
- 19 sites in United States
- Volunteers
- 86 people
- Sponsor
- Columbia University
Creatine Synthesis in Healthy Subjects
Creatine Kinetics, Synthesis From Glycine and Response to Creatine and Amino Acid Supplement in Healthy Humans
The goal of the present study is to quantify the rate of synthesis of creatine in healthy controls and endurance trained subjects.
- Trial name
- NCT01725503
- Testing
- Creatine and Amino Acid supplement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Menopausal, Perimenopause
Creatine HCl and Creatine Ethyl Ester Supplementation in Perimenopausal and Menopausal Women
The goal of this randomized controlled double-blind parallel-group interventional trial is to evaluate the effects of of dietary supplementation with creatine HCl and creatine ethyl ester supplementation on cognitive performance…
- Trial name
- CONCRET-MENOPA (NCT06660004)
- Testing
- Dietary Supplement: Experimental 1 Creatine HCl, Dietary Supplement: Experimental 2 Creatine HCl, Dietary Supplement: Experimental 3 Creatine Ethyl ester
- Where
- Serbia
- Volunteers
- 36 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Healthy
An Open-Label, Two-Arm Pilot Study of the Tolerability, Consumer Acceptability, and Exploratory Well-Being Outcomes of a Multi-Ingredient Protein Formula in Two Flavors in Healthy Adults
This is an open-label, two-arm pilot study designed to evaluate the tolerability, consumer acceptability, and well-being outcomes of a multi-ingredient protein formula, available in two flavors (Vanilla Protein Formula and…
- Trial name
- NCT07827014
- Testing
- Vanilla Protein Formula, Chocolate Protein Formula
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Amyotrophic Lateral Sclerosis
Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS]
The purpose of this study is to evaluate the safety and effectiveness of creatine treatment in amyotrophic lateral sclerosis (ALS). There is currently no known effective treatment for ALS.
- Trial name
- NCT00005674
- Testing
- Creatine
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Major Depressive Disorder
Creatine Augmentation Treatment in Major Depressive Disorder Subjects
Given 1) the established safety with short-term or long-term supplementation of Cr, 2) its potential usefulness in improving brain energy metabolism, 3) the reported abnormality in brain energy metabolism in MDD subjects, and 4)…
- Trial name
- NCT00729755
- Testing
- Creatine monohydrate
- Where
- 4 sites in South Korea
- Volunteers
- 59 people
- Sponsor
- Ewha Womans University
Creatine, Patellar Tendinopathy
Effects of Creatine and Rehabilitation Programin Athletes With Patellar Tendinopathy
The aim of this study are to analyze the effect of creatine ingestion in pain, histological properties of the tendon, body composition, strength and vertical jump performance in athletes with patellar tendinopathy that follow a…
- Trial name
- CREATINE_TEN (NCT06482619)
- Testing
- Creatine supplementation
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Universidad Pontificia Comillas
Acute Kidney Injury
Effect of Creatine on Serum and Urine Creatinine
Background: Creatinine (Crn) concentration is used to assess renal function via calculation of GFR (Glomerular Filtration Rate).
- Trial name
- ECSUC (NCT01367717)
- Testing
- Creatine Monohydrate, Creatine Ethyl Ester
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Medical Center
Chronic Fatigue Syndrome
Guanidinoacetic Acid Loading for Chronic Fatigue Syndrome
Chronic fatigue syndrome (CFS) is a debilitating condition of unknown etiology. Recent studies have shown that CFS is associated with impaired cellular energetics and low levels of phosphocreatine.
- Trial name
- NCT02213679
- Testing
- Guanidinoacetic acid
- Where
- Serbia
- Volunteers
- 20 people
- Sponsor
- Center for Health Sciences, Serbia
Rhabdomyolysis, Myopathy
Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients. 2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).
- Conditions
- Rhabdomyolysis, Myopathy, Acute Renal Failure, Neuroleptic Malignant Syndrome
- Trial name
- NCT01022450
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer
Resistance Exercise and Creatine in Colorectal Cancer
Low skeletal muscle mass and function, is prevalent in up to 60% of colorectal cancer patients. This condition arises from a combination of factors such as aging, inactivity, treatment side effects, malnutrition, tumor burden…
- Trial name
- NCT06420726
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of South Carolina
Heart Failure
Heart Failure and Risk of Re-Admissions Determined by Abnormal REVEAL Parameters
The purpose of the Heart Failure and Risk of re-Admissions Determined by Abnormal REVEAL Parameters (HF RADAR) study is to evaluate the ability of cardiac rhythm (Cardiac Compass) data to predict future cardiac events in heart…
- Trial name
- HF-RADAR (NCT01357408)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Heart Failure
Clinical Prospective ranDomized Trial to Evaluate the Non-inferiority of Left Bundle Branch Area Pacing Vs Cardiac ResynchronIzatioN Therapy With ECG guIded AV Optimization
Cardiac resynchronization therapy is the gold standard therapy for patients with advanced HF left ventricle dysfunction and large QRS.
- Trial name
- DA VINCI (NCT07107048)
- Testing
- Pacemaker and defibrillator
- Where
- Italy
- Volunteers
- 194 people
- Sponsor
- Leonardo Calò, MD
Healthy Lifestyle
Creatine Monohydrate Versus Creatine Hydrochloride on Strength and Body Composition in Elite Team-Sport Athletes
A triple-arm double-blinded placebo-controlled repeated-measures randomized clinical trial in Colombian elite team-sport athletes.
- Trial name
- CrM_CrHCl (NCT05697900)
- Testing
- Creatine Monohydrate, Creatine Hydrochloride
- Where
- Colombia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dynamical Business and Science Society - DBSS International SAS
Heart Failure
Care-HF CArdiac Resynchronization in Heart Failure
The CARE-HF trial evaluates the effects of Cardiac Resynchronization (CR) therapy on the mortality and morbidity of patients with heart failure due to left ventricular systolic dysfunction already receiving diuretics and optimal…
- Trial name
- NCT00170300
- Testing
- Implantable Cardiac Resynchronisation (pacing) device
- Volunteers
- 813 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure, Levosimendan
Study on the Correlation Between NAT2(N-acetyltransferase2) Gene Polymorphism and CrCl(Creatine Clreance) and the Efficacy and Safety of Levosimendan in Patients With Severe Heart Failure
1. To evaluate the efficacy and safety of levosimendan in the treatment of heart failure ; 2. Guide patients to apply levosimendan individually and establish a dose adjustment program.
- Conditions
- Heart Failure, Levosimendan, Efficacy, Safety
- Trial name
- NCT05913271
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Yi Han
Healthy Persons
Creatine Supplementation on Kidney Function in Resistance-trained Individuals
There is a claim that creatine supplementation might affect kidney function, especially in those consuming a high-protein diet. The aim of this study was to investigate the effects of creatine supplementation on kidney function…
- Trial name
- NCT01817673
- Testing
- creatine
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo