Clinical trials: Creatine
Hyperhomocysteinemia
The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy Volunteers
A methyl-group acceptor such as guanidinoacetic acid (GAA) could induce hyperhomocysteinemia with the effects of GAA expected to be dose-dependent.
- Trial name
- NCT01371357
- Testing
- TEST 1, TEST 2, TEST 3
- Where
- Serbia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Center for Health Sciences, Serbia
HIV Infections
Effects of Creatine and Resistance Exercise Training in People With HIV Infection
This study was designed determine whether use of creatine monohydrate, a dietary supplement, can increase skeletal muscle mass and strength and improve the response to progressive resistance exercise training in people with HIV…
- Trial name
- NCT00484627
- Testing
- Use of creatine monohydrate (a dietary supplement), Progressive resistance exercise training
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Resistance Training, Sports Nutrition
Effects of Three Carbohydrate Beverages on Resistance Training Performance
This randomized, triple-blinded, counterbalanced crossover trial compared three carbohydrate beverages that provided the same amount of carbohydrate (30 g) but differed in carbohydrate source: dextrose, maltodextrin, and highly…
- Conditions
- Resistance Training, Sports Nutrition, Dietary Carbohydrates
- Trial name
- NCT07874776
- Testing
- Dextrose, Maltodextrin, Highly Branched Cyclic Dextrin
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Aging, Sarcopenia
Effect of Creatine+HMB Supplementation in Physically Active Older Adults
Sarcopenia (SAR) is the loss of muscle strength and mass caused by aging. It is accompanied by a progressive decline in physical and cognitive abilities, increasing the risk of falls.
- Conditions
- Aging, Sarcopenia, Nutrition, Healthy
- Trial name
- CRESHARE (NCT05951439)
- Testing
- CRE + HMB
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Burgos
Coronary Artery Disease
Effect of Creatine and L-Arginine on Endothelial Function
The study is a double blind 2x2 factorial study. Patients with coronary disease will be randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary supplement.
- Trial name
- NCT00551434
- Testing
- Creatine, L-arginine and creatine, l-arginine
- Volunteers
- 119 people
- Sponsor
- Boston University
Neurologic Diseases, General
Intranasal Administration of Dodecyl Creatine Ester (CBT101) in Healthy Male Subjects
A Phase 1, Randomized, Double-Blinded, Placebo-Controlled study to Evaluate the Safety, Tolerability,and Pharmacokinetics of Single and Multiple Ascending Doses of CBT101 given intranasally in Healthy Male Subjects.
- Trial name
- CBT101 (NCT07050316)
- Testing
- CBT101
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ceres Brain Therapeutics
Knee Osteoarthritis
Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis
Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing…
- Trial name
- NCT04423432
- Testing
- Lower Extremity Resistance Exercise Training, Home Exercise Plan, Electrotherapy + Heating
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Perioperative Inflammatory Response
Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery
The purpose of the present study is to quantify the degree of modulation, if any, in the perioperative inflammatory response associated with statins use.
- Trial name
- NCT00656292
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Mayo Clinic
Depression, Anxiety
Creatine for Depressed Male and Female Methamphetamine Users
Assess the antidepressant/anxiolytic effect of creatine in male and female methamphetamine users Assess creatine's effect on methamphetamine use Assess the safety of creatine in male methamphetamine users with depression
- Conditions
- Depression, Anxiety, Methamphetamine Dependence
- Trial name
- NCT02568878
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Montana State University
Aging, Muscle Loss
D3-Creatine and Skeletal Muscle in Older Adults
The age-related decline in muscle mass and strength are collectively referred to as sarcopenia. However, the tools currently employed to assess skeletal muscle mass (SMM) (e.g., Dual-energy Xray Absorptiometry; DXA) have…
- Trial name
- D3-Cr (NCT06630949)
- Where
- Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- McMaster University
Anorexia, Cachexia
Creatine in Treating Patients With Cancer-Associated Weight Loss
RATIONALE: It is not yet known whether the supplement creatine is effective in increasing weight and improving appetite and quality of life in patients who have cancer.
- Conditions
- Anorexia, Cachexia, Unspecified Adult Solid Tumor, Protocol Specific, Weight Changes
- Trial name
- NCT00081250
- Testing
- creatine monohydrate
- Where
- 220 sites in United States
- Volunteers
- 300 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Heart Failure, Central Sleep Apnea
Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF
The primary objective of this study is to compare the Apnea- Hypopnea Index in HF patients with concomitant CSA, after 12 weeks of CRT alone to CRT in combination with one night of overdrive pacing.
- Trial name
- Morpheus (NCT00551499)
- Testing
- CRT + AOP
- Where
- 2 sites in Germany
- Volunteers
- 44 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Type 1 Diabetes
Impact of Eccentric Training in Hypoxia With Creatine on Metabolic Control and VO2max in Patients With Type 1 Diabetes
Exercise plays an important role in treatment of diabetes. In recent years exercise training in normobaric hypoxia is used in training programs for athletes and in rehabilitation and also commercially.
- Trial name
- NCT06345612
- Testing
- hypoxia, normoxia, creatine supplementation
- Where
- Poland
- Volunteers
- 28 people
- Sponsor
- Silesian Centre for Heart Diseases
Physical Fitness
Measuring Uniformed Servicemembers' Fitness Scores on Creatine Loading and Exercise
The purpose of this study is to compare the physical fitness performance-as measured by the Air Force Physical Fitness Test (PFT)-of subjects that, in conjunction with exercise, will take creatine supplementation over a four week…
- Trial name
- MUSSCLE (NCT02661334)
- Testing
- Creatine Monohydrate, Rice Flour
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Healthy Subjects
Effects of Betaine Supplementation on Strength and Muscle Creatine Content
It has been suggested that betaine supplementation may improve muscle strength by increasing muscle creatine content. However, there is no data supporting this assumption.
- Trial name
- NCT01213719
- Testing
- creatine, betaine, dextrose
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy
Pomegranate Improve Biological Recovery Kinetics in Elite Weightlifter
From the recent scientific literature in the field of biological response to physical exercise, a significant increase in muscle damage, soreness and inflammation were registered immediately and even 48 after resistance exercise.
- Trial name
- NCT02697903
- Testing
- Natural Pomegranate Juice
- Where
- Tunisia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- The Higher Institute of Sport and Physical Education of Sfax
Athletic Performance, Physical Endurance
Event-Specific Adaptations to CrossFit and Running-Based HIIT in Elite Distance Runners at Moderate Altitude
The goal of this clinical trial is to compare the effects of two high-intensity training programs on physical performance and physiological adaptations in elite male middle- and long-distance runners aged 25 to 35 years who live…
- Conditions
- Athletic Performance, Physical Endurance, Altitude Training Adaptation, Aerobic Capacity
- Trial name
- NCT07675577
- Testing
- Running-Based High-Intensity Interval Training (HIIT), CrossFit-Based High-Intensity Training (CF)
- Where
- Iran
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss
- Trial name
- PRESERVE-HMB (NCT07760948)
- Testing
- Calcium-HMB Plus Vitamin D3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Sarcopenia
Creatine HCl Supplementation in Sarcopenia: A Randomized Controlled Study
The CONCRET-SARCOPA trial is a 12-week, double-blind, randomized controlled study designed to evaluate the efficacy of creatine HCl supplementation in older adults with sarcopenia.
- Trial name
- SARCOPA (NCT07285226)
- Testing
- Experimental 1, Experimental 2
- Where
- Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Center for Health Sciences, Serbia
Amyotrophic Lateral Sclerosis (ALS)
Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis
The purpose of this study is to determine whether nine months of administration of creatine monohydrate results in an increase in muscle strength in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT00069186
- Testing
- Creatine Monohydrate
- Where
- 8 sites in United States
- Volunteers
- 107 people
- Sponsor
- The Avicena Group