Clinical trials: Creatine
Amyotrophic Lateral Sclerosis
Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS)
The purpose of the study is to evaluate the safety and efficacy of high dose creatine and two dosages of tamoxifen treatment in amyotrophic lateral sclerosis (ALS).
- Trial name
- SDALS-001 (NCT01257581)
- Testing
- creatine, tamoxifen
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Nazem Atassi
Diet-induced Thermogenesis, Brown Adipose Tissue Activation
Creatine Effect on Brown Adipose Tissue Activation
Pre-clinical studies indicate that creatine may play a substantial role in diet-induced thermogenesis and may have a profound effect on energy balance.
- Trial name
- CreaBAT (NCT04086381)
- Testing
- Creatine monohydrate
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Creatine Transporter Defect
Relevant Outcome Measures for Creatine Transporter Deficiency Patient
Creatine transport deficiency (CTD) is a rare genetic disorder related to pathogenic variants in the SLC6A8 gene, located on chromosome Xq28.
- Trial name
- CREAT_criteria (NCT06018519)
- Testing
- Clinical endpoints, Parental questionnaires, Quality of life scale
- Where
- France
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Rett Syndrome
Effects of Creatine Supplementation in Rett Syndrome
Creatine supplementation in RTT: a randomized controlled trial Rett Syndrome (RTT) is a neurodevelopmental disorder characterised by apparently normal early development (stage 1 of RTT) followed by loss of purposeful hand use…
- Trial name
- NCT01147575
- Testing
- Creatine monohydrate
- Where
- Austria
- Volunteers
- 21 people
- Sponsor
- Medical University of Vienna
Huntington Disease
Creatine Safety and Tolerability in Premanifest HD: PRECREST
PRECREST is a two phase protocol for Huntington's disease in which 60 premanifest and at-risk subjects will first be randomized into a double blind placebo controlled dose titration study bringing them to 30 grams daily or their…
- Trial name
- PRECREST (NCT00592995)
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Muscle Adaptation, Body Composition
Creatine and Muscle Health in Madrid's Walking Footballers.
Healthy aging requires effective, accessible, and sustainable interventions capable of preserving functional capacity and preventing age-related decline.
- Conditions
- Muscle Adaptation, Body Composition, Physical Activity in Adults
- Trial name
- MyoCreaWalk (NCT07891936)
- Testing
- Monohydrate Creatine supplementation during Walking Football training
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Stage IV Gastric Cancer, Stage IIIA Gastric Cancer
A Study of Creatine Combined With Curcumin in the Intervention of Early Cachexia in Upper Gastrointestinal Tumors
Cachexia is a common complication of various advanced malignant tumors, which seriously affects the quality of life and survival time of patients.
- Conditions
- Stage IV Gastric Cancer, Stage IIIA Gastric Cancer, Stage IIIB Gastric Cancer, Stage III Esophageal Cancer
- Trial name
- NCT05856500
- Testing
- basic nutrition, oral supplement of creatine and curcumin
- Volunteers
- 152 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Protein Deficiency, Training Group, Sensitivity
Effects of a Recovery Supplement on Body Composition, Performance, Muscular Properties, and Wellbeing
The investigation will be conducted as a double blinded, randomized, parallel between treatment conditions comparison design with two different groups ingesting a different supplement each one.
- Conditions
- Protein Deficiency, Training Group, Sensitivity, Fatigue, Muscular Atrophy
- Trial name
- NCT05769101
- Testing
- Ingestion of a Post-Workout Supplement, Ingestion of a Maltodextrin Supplement
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joel Puente
Healthy
Load and Hold: Impact of 7-Day Creatine Monohydrate Loading on Breath-Hold Cycling Performance
The present study aims to investigate the effects of creatine monohydrate supplementation on maximal breath-hold exercise performance on a bicycle ergometer in trained breath-hold divers.
- Trial name
- BREATHE-C (NCT07233707)
- Testing
- Creatine Monohydrate
- Where
- Greece
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Neovacular Age-related Macular Degeneration
UNcovering the Difference Between Ranibizumab and Aflibercept, Focusing on Systemic Anti-vascular Endothelial Growth Factor (VEGF) Effects in Patients With neovascuLar Age-related Macular Degeneration (AMD)
This study assessed systemic vascular endothelial growth factor (VEGF) level in patients with neovascular Age-related Macular Degeneration following treatment with Ranibizumab or Aflibercept.
- Trial name
- UNRAVEL (NCT01988662)
- Testing
- Neovascular Age-related Macular Degeneration
- Where
- 24 sites in Israel, Malaysia and 5 more
- Volunteers
- 205 people
- Sponsor
- Novartis Pharmaceuticals
Sarcopenia in Elderly, Frailty at Older Adults
Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty
Double-blind randomized placebo-controlled clinical trial with two parallel arms. The main objective is to evaluate the efficacy and safety of creatine supplementation in older adults who have been operated on for total knee…
- Conditions
- Sarcopenia in Elderly, Frailty at Older Adults, Functional Capacity, Creatine Supplementation
- Trial name
- CREAR (NCT06925880)
- Testing
- Creatine Monohydrate
- Where
- Spain
- Volunteers
- 262 people
- Sponsor
- Consorci Sanitari del Maresme
Menopause, Estrogen Deficiency
ATENEA Study: Adherence to Creatine-Based Nutritional Supplementation in Estrogen-Depleted Women
This is a prospective, multicenter, observational clinical study conducted under routine clinical practice conditions aimed at describing adherence to a creatine-based nutritional supplement (Creaticare FEM) in estrogen-depleted…
- Trial name
- ATENEA (NCT07580846)
- Where
- 4 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Margan Biotech
Exercise Performance Recovery
Effects of Creatine and Carbohydrate Supplementation on Endurance Performance
This study will examine the independent and combined effects of creatine and carbohydrate supplementation on exercise performance, compared to placebo.
- Trial name
- NCT07712653
- Testing
- Creatine Monohydrate, Carbohydrate, Creatine Monohydrate and Carbohydrate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Peripheral Arterial Disease
Creatine Use and Muscle Stretching in Peripheral Artery Disease
To utilize near-infrared spectroscopy to investigate if the research device, which induces muscle stretching, and creatine loading impact submaximal exercise performance in aged and PAD patients.
- Trial name
- NCT04471792
- Testing
- Creatine monohydrate, Cellulose
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Florida State University
Exercise Performance
Creatine Supplementation At Simulated Altitude
Creatine supplementation has been shown to increase exercise performance at sea level. The goal of this study is to determine the effects of creatine supplementation on exercise performance at simulated altitude.
- Trial name
- NCT06489587
- Testing
- Creatine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Pompe Disease, Muscle Loss
Nutritional Therapy in Late-onset Pompe Disease
RATIONALE: Pompe disease (PD) is a recessive genetic disorder wherein the body cannot break down glycogen due to a mutation in the acid alpha glucosidase (GAA) gene, which encodes for acid alpha-glucosidase.
- Conditions
- Pompe Disease, Muscle Loss, Obesity, Nutrition Poor
- Trial name
- PDT-MIS (NCT06130228)
- Testing
- Multi-ingredient supplement (PDT-MIS)
- Volunteers
- 28 people
- Sponsor
- McMaster University
Mild Traumatic Brain Injury, Concussion (Diagnosis)
Creatine Monohydrate for Mild Traumatic Brain Injury: a Randomised Controlled Pilot Study
Objectives: Approximately one-third of patients with concussion experience persistent symptoms that, in addition to causing serious discomfort, may lead to unemployment and other socioeconomic challenges.
- Trial name
- NCT06644131
- Testing
- Creatine Monohydrate
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Southern Denmark
Primary Lateral Sclerosis, Hereditary Spastic Paraplegia
Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
This study will use a magnetic resonance imaging technique called nuclear magnetic spectroscopy (H-MRS) to define the pathology and progression of primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral…
- Conditions
- Primary Lateral Sclerosis, Hereditary Spastic Paraplegia, Amyotrophic Lateral Sclerosis
- Trial name
- NCT00023075
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Athletes
Creatine Supplementation for Female Football
Creatine is an effective, inexpensive, and safe dietary supplement, which has been largely used in sports and clinical populations.
- Trial name
- NCT06250556
- Testing
- creatine
- Where
- 2 sites in Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Ectopic Pregnancy
Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy
Patients who have doubt for ectopic pregnancy will be enrolled for our study. These patients will be determined with using irregular increased human chorionic gonadotropin (beta-HCG) results and no embryo reported ultrasonography…
- Trial name
- NCT02995356
- Testing
- Collecting cervical liquid and sera samples
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Ege University