Clinical trials: Creatine
Major Depressive Disorder
5-HTP and Creatine for Depression R33 Phase
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression.
- Trial name
- NCT05895747
- Testing
- Low Dose 5-hydroxytryptophan, High Dose 5-hydroxytryptophan, Low Dose Creatine Monohydrate
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Utah
Cirrhosis, Frailty
Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis
Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining…
- Conditions
- Cirrhosis, Frailty, Sarcopenia
- Trial name
- NCT07029243
- Testing
- HEAL-ME digital app, Creatine supplementation, Whey protein supplementation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Depression, Substance Abuse
Creatine as a Treatment Option for Depression in Methamphetamine Using Females
Methamphetamine (MA) is a psychostimulant drug with high abuse potential. MA can be smoked, snorted, injected or ingested orally to produce a release of high levels of dopamine into the brain and reduction of dopamine uptake.
- Conditions
- Depression, Substance Abuse, Substance Use, Neuroimaging
- Trial name
- NCT01514630
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Perry Renshaw
Sarcopenia
Estimation of Muscle Mass in Older Adults Using Deuterated Creatine
Current methods for the quantification of muscle mass are indirect, lack precision, and often rely on expensive equipment that only provides limited (indirect) data on whole body muscle mass.
- Trial name
- MM-DC (NCT02062086)
- Testing
- deuterated creatine 30 mg
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Toulouse
Endothelial Dysfunction
The Effect of NADPH Oxidase and Creatine Supplementation on Microvascular Blood Flow Regulation
This research study seeks to determine the effects of an enzyme in the human body called NADPH oxidase (NOX) on blood flow. In addition, the study will investigate the benefits of creatine monohydrate, a common sports performance…
- Trial name
- NOXCROS (NCT06018480)
- Testing
- Creatine Monohydrate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Florida State University
Parkinson's Disease
National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial
The goal of this study is to assess the impact of minocycline and creatine on the progression of Parkinson's disease, in order to determine whether it is reasonable to proceed with further study of either of these agents.
- Trial name
- NCT00063193
- Testing
- minocycline, creatine
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- University of Rochester
Major Depressive Disorder
Creatine Augmentation in Veterans With SSRI-Resistant Major Depression
The purpose of this study is to determine whether creatine will be helpful as an adjunctive treatment for treatment-resistant major depressive disorder (MDD) in female and male Veterans.
- Trial name
- NCT01175616
- Testing
- Creatine
- Sponsor
- University of Utah
Endothelial Dysfunction, Oxidative Stress
Creatine Monohydrate Supplementation and Vascular Endothelial Health
To determine the effects of 4 weeks of creatine monohydrate supplementation on markers of macrovascular and microvascular function, cognitive performance, and physical performance.
- Trial name
- NCT05014659
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Florida State University
Heart Failure
Clinical Evaluation of LEft VEntricular Auto Threshold Algorithm (LEVEA)
The purpose of the LEVEA study is to assess the performances of a new automatic left ventricular auto threshold (LVAT) algorithm (In-Clinic LVAT algorithm) when used by physicians during in-hospital follow-up.
- Trial name
- LEVEA (NCT03014180)
- Testing
- "In-Clinic LVAT"
- Where
- France
- Volunteers
- 60 people
- Sponsor
- LivaNova
Fibromyalgia
Effectiveness of Creatine on Pain, Fatigue, and Muscle Architectural Variables in Patients Witg Fibromyalgia.
Creatine, a non-protein organic amino acid, is synthesized from arginine, glycine, and methionine. The use of creatine has been shown to be effective in healthy subjects, providing benefits primarily in terms of strength, which…
- Trial name
- SECPFMAPFM (NCT06675708)
- Testing
- Creatine, Dextrose
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Camilo Jose Cela University
Colitis, Ulcerative
Therapeutic Modulation of the Intestinal Creatine Kinase System in Inflammatory Bowel Disease (IBD)
This study plans to learn more about the effects that creatine monohydrate has on disease activity in ulcerative colitis. Creatine is a substance that is naturally produced by the body and is found in foods, such as meat and…
- Trial name
- NCT02463305
- Testing
- Creatine monohydrate
- Where
- United States
- Sponsor
- University of Colorado, Denver
Osteopenia, Osteoporosis
Creatine Supplementation and Bone Mass
Resistance training as well as creatine supplementation may increase bone mass. Therefore, the investigators speculate that resistance training combined with creatine supplementation would promote additive benefits on bone mass…
- Trial name
- NCT01163370
- Testing
- creatine supplementation, exercise training
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Burn Injury
The Effect of Acute Phase Treatment Approaches on Creatine Kinase and the Musculoskeletal System in Different Types of Burns
There are very few studies indicating the effect of acute phase treatment approaches on creatine kinase and the musculoskeletal system in the physiotherapy and rehabilitation process.
- Trial name
- NCT04417439
- Testing
- universal goniometer. evaluate the circumference measurement. The biochemical examination of CK (creatine kinase)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Inonu University
Epileptic Seizure, Creatine Kinase
Impact of Early Lactate Dosage Compared to CK for Diagnosis of a Suspected Seizure
Defining the origin of a seizure remains a difficult diagnosis. The presence of witness is not systematic, the clinical examination can be little contributory, and the delay recommended by the FSN is often surpassed for the…
- Conditions
- Epileptic Seizure, Creatine Kinase, Lactate, Epileptic Generalized Tonic-clonic Seizure
- Trial name
- NCT03163719
- Testing
- CK and Lactate dosages
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Exercise Induced Muscle Damage, Cryotherapy
Acute Cryotherapy on Musculoskeletal Function and Biomarkers
In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more…
- Trial name
- NCT07211412
- Testing
- Cryotherapy, Eccentric exercise-induced muscle damage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Major Depressive Disorder
Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram
The purpose of this study is to see if creatine, which is a naturally occurring chemical in the body, is effective for treating Major Depressive Disorder (MDD) in female teenagers.
- Trial name
- NCT00851006
- Testing
- Creatine Monohydrate
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cold-water Immersion, Protein-carbohydrates Supplementation
Effects on CK, RPE, VAS Scale and Physical Performance of Three Recovery Methods in Elite Basketball Players
The aim of this study was to compare the effects of cold water intermittent ion (CWI), carbohydrate and protein supplementation (SUPPL), and active recovery (ACT) on creatine kinase (CK), perceptual and performance markers of…
- Conditions
- Cold-water Immersion, Protein-carbohydrates Supplementation, Active Recovery, Placebo
- Trial name
- NCT05805540
- Testing
- Cold-water immersion, Protein-carbohydrates supplementation, Active recovery
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Heart Valve Diseases
Sodium Creatine Phosphate in Heart Valve Surgery
To explore the effect of intraoperative sodium creatine phosphate on myocardial protection in patients undergoing valve surgery
- Trial name
- NCT03186053
- Testing
- sodium creatine phosphate, saline
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Progressive Supranuclear Palsy
A Pilot Clinical Trial of Pyruvate, Creatine, and Niacinamide in Progressive Supranuclear Palsy.
This study intends to study the safety and tolerance of the combination of pyruvate, creatine, and niacinamide over 6 months in patients with PSP.
- Trial name
- NCT00605930
- Testing
- Pyruvate, creatine, niacinamide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Sarcopenia
Older Adult Training Study With Creatine and CLA
We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise…
- Trial name
- OTR (NCT00473902)
- Testing
- Training, Creatine Monohydrate, Conjugated Linoleic Acid
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation