Clinical trials: Creatine
Sarcopenia in Elderly
Effects of Resistance-band Training and Creatine and Whey Protein
The primary purpose of this research is to compare the effects of creatine monohydrate and/or whey protein supplementation during the first 10 weeks of a 20-week resistance-band training program on measures of body composition…
- Trial name
- NCT06606717
- Testing
- Creatine Whey Protein, Whey Protein
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Regina
Mild Traumatic Brain Injury, Concussion, Brain
The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms
The purpose of this study, is to investigate whether creatine monohydrate as a supplement reduces the number and severity of symptoms in patients with persistent post-concussive symptoms through self-reported post-concussion…
- Trial name
- NCT05562232
- Testing
- Creatine Monohydrate
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Side Effects of Creatine Monohydrate Dosing
Gastrointestinal and Fluid Retention Symptoms Associated With Creatine Monohydrate With and Without Loading Dose Over 28 Days of Supplementation
This study aimed to investigate the incidence and severity of GI symptoms associated with daily CM supplementation, with and without a loading phase, in healthy male and female adults.
- Trial name
- NCT07176325
- Testing
- Creatine Monohydrate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vireo Systems, Inc.
Presbyphonia
Creatine Supplementation for Improved Voice Performance in the Elderly
The primary objective of this study is to determine if creatine supplementation improves acoustic, auditory perceptual, physiologic, and patient-reported outcome measures in patients over 65 years of age.
- Trial name
- NCT05856916
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Sarcopenia
Effects of High-velocity Resistance Training and Creatine Supplementation in Healthy Aging Males
The age-related loss of skeletal muscle mass (i.e. sarcopenia)and muscle performance (i.e. strength and power), decreases functionality and the ability to perform activities of daily living.
- Trial name
- NCT03530202
- Testing
- Creatine monohydrate, Maltodextrin Powder
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Regina
Depression
Creatine Monohydrate Use for Preventing Altitude Induced Depression
This study involves the use of an investigational drug called Creatine Monohydrate. This means that the drug has not yet been approved by the Food \& Drug Administration (FDA) for treatment of altitude-induced depression.
- Trial name
- NCT03433651
- Testing
- Creatine monohydrate
- Where
- United States
- Sponsor
- Mike O'Callaghan Military Hospital
Prolonged Mechanical Ventilation, Critical Illness
Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support.
- Trial name
- SECRET-VENT (NCT07177183)
- Testing
- Dietary supplement creatine, No intervention
- Where
- 2 sites in Czechia
- Volunteers
- 492 people
- Sponsor
- University Hospital Ostrava
Sarcopenia
Time Course Adaptations Using Deuterated Creatine (D3Cr) Method
The pilot study is to assess the feasibility of using a new method to measure muscle mass called Deuterated Creatine (D3Cr) method and thereby understand the role of muscle mass on functional outcomes in older adults.
- Trial name
- NCT03573583
- Testing
- Resistance Training, Successful Aging
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Depression, Bipolar
Combined Cytidine and Creatine-containing Drug in the Treatment of the Bipolar Depression
This research is aimed to investigate the efficacy and safety of the creatine and cytidine augmentation in treating bipolar depression and to evaluate changes in relevant brain biochemical metabolism using proton and phosphorous…
- Trial name
- NCT02625779
- Testing
- Valproate and Cytidine-containing Drug, Valproate and Creatine-containing Drug
- Where
- South Korea
- Sponsor
- Ewha Womans University Mokdong Hospital
Major Depressive Disorder
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The primary hypothesis is that compared to placebo, 10g of daily creatine monohydrate for eight weeks will be associated with significant increases in frontal lobe phosphocreatine and beta-nucleoside triphosphate (β-NTP)…
- Trial name
- NCT02134808
- Testing
- Creatine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Rett Syndrome
Creatine Metabolism in Rett Syndrome
Rett syndrome (RTT) is an X-linked severe neurodevelopmental disorder. Despite their good appetite, many females with RTT meet the criteria for moderate to severe malnutrition. The pathological mechanism is barely understood.
- Trial name
- NCT01198015
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Maastricht University Medical Center
Concussion, Brain
Creatine Supplementation in Concussion Recovery
The proposed study aims to compare concussion recovery in those supplementing creatine and those not supplementing creatine. Specific aim 1: To compare number of days until asymptomatic between those taking creatine vs.
- Trial name
- CSCR (NCT06208813)
- Testing
- Creatine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- San Diego State University
Obesity, Women (Between 30 to 60 Years Old)
Increased Dietary Protein Intake During GLP-1 Medication Use (in Middle-aged Women With Overweight/Obesity)
Middle-aged women with (overweight/)obesity who will begin or have begun GLP-1 medication use will be recruited to complete a 12-week diet intervention study.
- Trial name
- NCT07480109
- Testing
- Protein Rich Foods
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Cognitive Benefits
Citicoline, Creatine, and Omega-3 Effects in Middle Age Women
The purpose of this study is to determine the functional effects of a citicoline, creatine, and omega-3 fatty acids combination when administered for a duration of four weeks (28 days) to non-psychiatric adult female participants.
- Trial name
- NCT01502813
- Testing
- Citicoline, Omega-3 Fatty Acids and Creatine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Deborah Yurgelun-Todd
Placenta Accreta
Creatine Kinase Versus 3D Doppler for Antenatal Diagnosis of Abnormal Adherent Placenta.
Placenta accreta is a potentially life-threatening obstetric condition that requires a multidisciplinary approach to management.Diagnosis of placenta accreta before delivery minimizes potential maternal or neonatal morbidity and…
- Trial name
- NCT03224780
- Testing
- maternal serum creatine kinase, 3D Doppler ultrasound
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Frailty, Sarcopenia
Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Muscle Function in Sarcopenic Frailty
Sarcopenia and physical frailty are highly prevalent among institutionalized older adults and are major contributors to functional decline, reduced mobility, and loss of independence.
- Conditions
- Frailty, Sarcopenia, Aging, Malnutrition Elderly
- Trial name
- MULTI-FRAIL (NCT07275996)
- Testing
- Creatine Monohydrate, Multicomponent Exercise Program, β-Hydroxy-β-Methylbutyrate (HMB)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Burgos
Major Depressive Disorder
Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females
The investigators propose to determine if 8 weeks of dietary augmentation with oral 5g creatine monohydrate daily and 100 mg of 5-hydroxytryptophan (5-HTP) twice daily reduces hypoxia-related depressive symptoms measured by the…
- Trial name
- NCT02922725
- Testing
- 5-hydroxytryptophan and Creatine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brent Michael Kious, MD, PhD
Creatine Deficiency, X-linked
Observational Study of Males With Creatine Transporter Deficiency
The objectives of this study are to illustrate the clinical, neuro/electrophysiologic, biochemical, and developmental status and progression of patients with Creatine Transporter Deficiency (CTD) and to evaluate the utility of…
- Trial name
- Vigilan (NCT02931682)
- Where
- 10 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Breast Cancer, Chemotherapy Effect
Effects of Creatine Supplementation in Breast Cancer Survivors
The purpose of this study is to test the hypothesis that creatine will accelerate adaptations associated with exercise in breast cancer survivors recently completing chemotherapy.
- Conditions
- Breast Cancer, Chemotherapy Effect, Muscle Weakness, Muscle Loss
- Trial name
- NCT04207359
- Testing
- Creatine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Dialysis; Complications
Intradialytic Creatine Supplementation
We perform a pilot study to investigate whether intra-dialytic creatine supplementation via the dialysate will result in higher intra-erythrocyte creatine concentrations.
- Trial name
- NCT05148208
- Testing
- Creatine supplementation to dialysate
- Volunteers
- 16 people
- Sponsor
- University Medical Center Groningen