Clinical trials: Crimean-Congo Hemorrhagic Fever
Crimean-Congo Haemorrhagic Fever
Development Of A Rapid Diagnostic Test To Identify Crimean-Congo Haemorrhagic Fever At The Point-Of-Care
The goal of this medical device diagnostic evaluation study is to determine if this novel lateral flow device can detect Crimean-Congo Hemorrhagic Fever (CCHF) at the point of care in secondary health care clinics in Turkey.
- Trial name
- NCT06624787
- Testing
- Rapid Diagnostic Test
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 492 people
- Sponsor
- Liverpool School of Tropical Medicine
Crimean Congo Hemorrhagic Fever
Study to Evaluate Safety and Immunogenicity of DNA Vaccine N-pVAX1 Against Crimean Congo Hemorrhagic Fever
This First-in-human dose-escalation vaccine phase I study aims to evaluate safety and reactogenicity of the investigational vaccine N-pVAX1, against Crimean Congo Hemorrhagic Fever, delivered by in vivo EP given as three im doses…
- Trial name
- CCHF-NP-1 (NCT06684431)
- Testing
- N-pVAX1
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Crimean-Congo Hemorrhagic Fever, Lassa Fever
Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities
This is a Phase 2 study of the safety and efficacy of Intravenous (IV) Ribavirin in treating patients presenting with a probable or suspected case of viral hemorrhagic fever (either Crimean Congo or Lassa Fever) at a military…
- Trial name
- NCT00992693
- Testing
- Ribavirin (Virazole) Injection
- Where
- Germany
- Sponsor
- U.S. Army Medical Research and Development Command
Viral Hemorrhagic Fever
Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever
Is ribavirin a therapeutic option for patients with a probable or suspected case of viral hemorrhagic fever?
- Trial name
- NCT02483260
- Testing
- Ribavirin
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- U.S. Army Medical Research and Development Command
Crimean-Congo Hemorrhagic Fever
Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans
This study covers the first trial of the Crimean-Congo Hemorrhagic fever virus (CKKA) vaccine on humans (healthy volunteers), which has been developed in Turkey and has completed preclinical toxicology studies to be performed on…
- Trial name
- NCT03020771
- Testing
- KIRIM-KONGO-VAX
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Scientific and Technological Research Council of Turkey
Infectious Diseases, Emerging
Development of a Rapid Diagnostic Test to Identify Crimean-Congo Hemorrhagic Fever - Research and Development Testing
Background Crimean-Congo Haemorrhagic Fever (CCHF) is a rare disease with a death rate between 10% and 50%, rising to 80% during outbreaks.
- Trial name
- DETECT-R&D (NCT06894758)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Vaccine, Crimean-Congo Hemorrhagic Fever
Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against Crimean-Congo Hemorrhagic Fever
The goal of this clinical trial is to assess the safety, tolerability and immunogenicity of three dosage levels, and a single or two-dose administration regimen, of the investigational HDT-321 product administered…
- Trial name
- NCT06799013
- Testing
- 10 ug HDT 321, 25ug HDT-321, 50ug HDT-321
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- HDT Bio
Crimean-Congo Hemorrhagic Fever
UMIT-2 - Adaptive Phase IIb Platform Trial to Determine the Efficacy and Safety of Therapeutics for CCHF
CCHF has a wide geographical distribution with cases mainly occurring in Asia, the Middle East, South-Eastern Europe and Africa.
- Trial name
- UMIT-2 (NCT06860334)
- Testing
- Favipiravir, Ribavin, Optimised Standard of Care
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 378 people
- Sponsor
- Liverpool School of Tropical Medicine
Leishmaniasis, Leptospirosis
Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases
Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments).
- Conditions
- Leishmaniasis, Leptospirosis, Brucellosis, Q Fever
- Trial name
- SEZAM (NCT06859619)
- Testing
- Peripheral venous blood sample
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Montpellier