Clinical trials: Critical Care, Intensive Care
Respiratory Failure, Critical Illness
The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients…
- Conditions
- Respiratory Failure, Critical Illness, Respiratory Distress Syndrome, Adult, Lung Injury
- Trial name
- NCT06203405
- Testing
- Titrating sedation targeting both optimal P0.1 and appropriate arousal level, Fentanyl, Midazolam
- Where
- Thailand
- Volunteers
- 214 people
- Sponsor
- Siriraj Hospital
Pneumonia
PNEUmonia DOSing in Critically Ill Patients (PNEUDOS)
Pneumonia is the most common infection in intensive care unit (ICU) patients and occurs in 10% of all ICU admissions. Unfortunately, ICU patient outcomes remain poor with a high mortality rate associated with pneumonia despite…
- Trial name
- PNEUDOS (NCT04986254)
- Testing
- Blood sampling, Epithelial lining fluid sampling, Urine sampling
- Where
- 6 sites in Australia, Belgium and 3 more
- Volunteers
- 179 people
- Sponsor
- The University of Queensland
Critical Illness, Enteral Nutrition
Early Enteral Feeding and Clinical Outcomes in ICU Patients
This study evaluated the effectiveness of an early enteral feeding protocol in critically ill adult patients admitted to an Intensive Care Unit (ICU).
- Conditions
- Critical Illness, Enteral Nutrition, Intensive Care Unit ICU, Nutritional Support
- Trial name
- EEFP (NCT07131098)
- Testing
- Early Enteral Feeding Protocol, Standard Nutritional Care
- Where
- Palestinian Territories
- Volunteers
- 80 people
- Sponsor
- Loai Muawiah Zabin
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Critically Ill
Prevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: The PREVAIL Study
Lactoferrin is a protein that is a component of the immune system. It has many properties that could make it the ideal agent for the prevention of hospital-acquired infections.
- Trial name
- PREVAIL (NCT01996579)
- Testing
- Lactoferrin
- Where
- Canada
- Volunteers
- 214 people
- Sponsor
- Queen's University
Critical Illness, Refeeding Syndrome
Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome
The overall aim of the study is to improve understanding of refeeding syndrome (RFS) in patients admitted to the intensive care unit (ICU) using metabolomics.
- Conditions
- Critical Illness, Refeeding Syndrome, Hypophosphatemia
- Trial name
- NCT06344546
- Testing
- Metabolomics
- Where
- 4 sites in Czechia, Italy and 1 more
- Volunteers
- 218 people
- Sponsor
- Karolinska University Hospital
Intensive Care, Mechanical Ventilation
Predictive Algorithms for Critical Rehabilitation Outcomes
An increasing amount of evidence from evidence-based medicine indicates that early rehabilitation intervention for patients receiving mechanical ventilation is safe and feasible, and can promote functional recovery and reduce…
- Conditions
- Intensive Care, Mechanical Ventilation, Rehabilitation, Algorithms
- Trial name
- NCT06532994
- Testing
- Early rehabilitation intervention
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Wuhan University
Critical Illness, Pediatrics
Comparing Cardiac Output Measurements in Critically Ill Children Using USCOM and Transthoracic ECHO
The purpose of this study is to compare the accuracy and precision of two non-invasive methods of measuring cardiac output in critically ill children (<18 yrs).
- Trial name
- NCT01460329
- Testing
- Ultrasonic Cardiac Output Monitor (USCOM).
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of North Carolina, Chapel Hill
Critical Illness, Pneumonia, Viral
D-Dimer as Predictor of Disease Outcome in Intensive Care Unit in COVID-19m Patients
Evaluating value of D-Dimer blood level of icu admitted patients on admission and 48 hours later as outcome predictor in SARS.COV.2 patients.
- Trial name
- COVID-19 (NCT05279469)
- Testing
- no intervention, just observational for D-Dimer level in blood
- Where
- 2 sites in Egypt
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Delirium
Melatonin for Treatment of Delirium in Critically Ill Adult Patients
The purpose of this study is to determine the feasibility of conducting a randomized controlled trial (RCT) with melatonin for treatment of delirium in critically ill adult patients.
- Trial name
- DELIRE-ICU (NCT05713877)
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Critical Illness, Multi Organ Failure
Parathyroid Hormone Kinetics During CRRT
The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergoing citrate anticoagulation…
- Conditions
- Critical Illness, Multi Organ Failure, Renal Failure, Circulatory Failure
- Trial name
- NCT03873675
- Testing
- parathyroid hormone
- Where
- 3 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Tissue Hypoperfusion, Critical Illness
Fecal Lactate and Resuscitation Outcomes in Critical Illness
This study evaluates the prognostic value of fecal lactate and the fecal-to-serum lactate gradient as early biomarkers of tissue hypoperfusion in critically ill patients.
- Conditions
- Tissue Hypoperfusion, Critical Illness, Shock, Sepsis
- Trial name
- DELTA-LAC (NCT07658001)
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital H+ Queretaro
Circulatory Failure, Fluid Volume Disorder
Volume Responsiveness Assesment After Propofol.
Patients in ICU who suffer from circulatory insufficiency, regardless the cause that require invasive hemodynamic monitoring. The aim of the study is to correlate stroke volume variation which predicts fluid responsiveness with…
- Conditions
- Circulatory Failure, Fluid Volume Disorder, Critical Illness
- Trial name
- NCT03917446
- Testing
- Propofol bolus
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Gdansk
Critical Care, Patient Satisfaction
The Effect of Nursing Care Based on Kolcaba's Comfort Theory on of Intensive Care Patients
Nurses aim to care for people who can no longer carry out their life activities and needs, and to ensure that they can continue to live their lives as well as possible.
- Trial name
- NCT05791903
- Testing
- Nursing Care Based on Kolcaba's Comfort Theory
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Acute Kidney Injury, Renal Replacement Therapy
Albumin To Enhance Recovery After Acute Kidney Injury
Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses)…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
- Trial name
- ALTER-AKI (NCT04705896)
- Testing
- 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL)
- Where
- 16 sites in Canada
- Volunteers
- 856 people
- Sponsor
- Ottawa Hospital Research Institute
Motor Activity, Muscle Strength
Critical Care Observation of Motor Activity (COMA) and SICU Outcomes
In the surgical intensive care unit (SICU), goals of critical care are often discussed in long-term ventilated patients around the time of extubation.
- Conditions
- Motor Activity, Muscle Strength, Muscle Weakness
- Trial name
- COMA (NCT02994641)
- Testing
- COMA Score Assessment
- Where
- United States
- Volunteers
- 761 people
- Sponsor
- Massachusetts General Hospital
Quality of Life, COVID-19
COVID-19 Follow up Intensive Care Studies
Since the SARS-CoV-2 infection is relatively new, the long term attributable burden related to COVID19 has not been investigated yet.
- Trial name
- COFICS (NCT04460170)
- Where
- Netherlands
- Volunteers
- 122 people
- Sponsor
- University Medical Center Groningen
Critical Illness, Sedation Complication
Sedation, ANalgesia and Delirium MANagement in Intensive Care Unit
Patients with acute severe health problems often need to be admitted to specialised hospital wards called Intensive Care Units (ICUs) where they can receive emergency treatment such as mechanical ventilation to support their…
- Conditions
- Critical Illness, Sedation Complication, Intensive Care Unit Delirium, Analgesia
- Trial name
- SAnDMAN (NCT05027217)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 3,421 people
- Sponsor
- University of Oxford
Post Intensive Care Unit Syndrome, Critical Illness
Improving Recovery After Critical Illness
Rationale: Survival rates of patients with critical illness have increased due to improved facilities and treatment methods in the intensive care unit (ICU).
- Conditions
- Post Intensive Care Unit Syndrome, Critical Illness, Malnutrition, Muscle Weakness
- Trial name
- IMPROVE (NCT05182086)
- Testing
- Group physical therapy and dietary improvements
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Frisius Medisch Centrum