Clinical trials: Critical Ill Patients
Tissue Hypoperfusion, Critical Illness
Fecal Lactate and Resuscitation Outcomes in Critical Illness
This study evaluates the prognostic value of fecal lactate and the fecal-to-serum lactate gradient as early biomarkers of tissue hypoperfusion in critically ill patients.
- Conditions
- Tissue Hypoperfusion, Critical Illness, Shock, Sepsis
- Trial name
- DELTA-LAC (NCT07658001)
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital H+ Queretaro
Oncology, Critical Illness
Indwelling Device-associated Biofilms
Healthcare associated infections linked to the use of indwelling medical devices increase hospital morbidity, mortality and the Intensive Care treatment costs.
- Conditions
- Oncology, Critical Illness, Sepsis, Hospital Infection
- Trial name
- BiofilmICU (NCT04328818)
- Testing
- indwelling device biofilm identification
- Where
- Romania
- Volunteers
- 150 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Critical Illness, Malnutrition
The Effect of Higher Protein Dosing in Critically Ill Patients Ultrasound a Sub-study
The investigators will evaluate the effects of of higher protein/amino acid dosing (≥2.2 g/kg/d) vs usual care of protein/amino acid dosing (≤1.2 g/kg/d) over muscle mass in nutritionally high risk ill patients.
- Trial name
- EFFORTUS (NCT04242966)
- Testing
- Usual Care, Higher Protein/Amino Acid Group, Ultrasound measure
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Delirium
Incidence of Delirium in Critically Ill Patients in a Dutch University Hospital
The objective of this study is to determine the incidence of delirium in adults patients who are admitted at the critical care unit of a Dutch University Hospital.
- Trial name
- NCT00604773
- Where
- Netherlands
- Volunteers
- 700 people
- Sponsor
- Radboud University Medical Center
Pneumonia, Critical Illness
Drug Resistance Factors In Healthcare-associated Pneumonia
Recently clinical guidelines categorize pneumonia in to three types: community, healthcare-associated, and hospital-acquired. Much of the existing research to describe the epidemiology of pneumonia in critically ill patients…
- Trial name
- DEFINE (NCT02736097)
- Where
- 30 sites in United States, Saudi Arabia
- Volunteers
- 679 people
- Sponsor
- Critical Care Pharmacotherapy Trials Network
Acute Kidney Injury
A Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism
Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.
- Trial name
- CAT-RISK (NCT07751874)
- Testing
- continuous renal replacement therapy with regional citrate anticoagulation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Sepsis, Critical Illness
Evaluation of the Effect of Immune Modulating Enteral Nutrition Formula
The aim is to compare the efficacy and tolerability of an immune modulating enteral nutrition formula versus the regular formula on the outcomes of critically ill septic patients by assessment of clinical outcomes, immune…
- Trial name
- NCT05186480
- Testing
- Neo Mune
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- NewGiza University
Critical Illness
PICU Patient Diary
The PICU-Diary study is a prospective single centre pilot study in the Pediatric Critical Care Unit at McMaster Children's Hospital.
- Trial name
- NCT03777527
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sepsis, Shock
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness.
- Trial name
- NCT00745888
- Testing
- Chemiluminescence Analyzer
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Critical Illness, Multiple Organ Failure
Adding a Gastrointestinal Subscore to SOFA2 for Mortality Risk Assessment in the ICU: The SOFA2-GIS Study
The goal of this observational study is to learn whether adding a gastrointestinal (GI) component to a widely used organ failure score improves the prediction of death risk in critically ill adults treated in the intensive care…
- Conditions
- Critical Illness, Multiple Organ Failure, Gastrointestinal Diseases, Mortality
- Trial name
- SOFA2-GIS (NCT07586254)
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people
- Sponsor
- Ozkul Yilmaz Colak
Severe Acute Respiratory Infection
Viral Etiology of Severe Acute Respiratory InFection in CriticallY Ill Patients Registry
SARI is a major public health problem in Saudi Arabia and leads to considerable morbidity and mortality. Most SARI-related mortality occurs in patients admitted to ICUs across the country.
- Trial name
- VERIFY (NCT06627166)
- Where
- Saudi Arabia
- Volunteers
- 13 people
- Sponsor
- King Abdullah International Medical Research Center
Critical Illness
Intravenous Versus Subcutaneous Administration of Low Molecular Weight Heparin for Thromboprophylaxis in Critically Ill Patients
Objective: To compare the pharmacokinetic profiles of intravenous versus subcutaneous route of administration of LMWH for thromboprophylaxis in critically ill patients
- Trial name
- NCT04982055
- Testing
- Nadroparin (intravenous Infusion), Nadroparin (subcutaneous group)
- Volunteers
- 60 people
- Sponsor
- Clinique Saint Pierre Ottignies
Mechanical Ventilation, Pulmonary Rehabilitation
Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.
This international, multicenter, observational study aims to describe rehabilitation practices in Intensive Care Units (ICUs) worldwide.
- Conditions
- Mechanical Ventilation, Pulmonary Rehabilitation, Intensive Care Units (ICUs), Quality of Life (QOL)
- Trial name
- REPOrt (NCT07093125)
- Where
- Italy
- Volunteers
- 2,400 people
- Sponsor
- Universita degli Studi di Genova
Disseminated Intravascular Coagulation, Critical Illness
Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical Infections
Inflammation and abnormalities in laboratory coagulation tests are inseparably tied. For example, coagulation abnormalities are nearly universal in septic patients.
- Conditions
- Disseminated Intravascular Coagulation, Critical Illness, Sars-CoV2, Viral Infection
- Trial name
- NCT04356144
- Testing
- Thrombin Generation Assay (TGA), Thrombomodulin Modified Thrombin Generation Assay (TGA-TM)
- Where
- Austria
- Volunteers
- 58 people
- Sponsor
- Medical University of Vienna
Critical Illness, Acute Kidney Injury
Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)
Worldwide, the use of Extracorporeal Blood Purification (EBP) in everyday clinical practice is becoming increasingly common, particularly in critical care settings.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- GlobalARRT (NCT04580680)
- Testing
- Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Careggi Hospital
Critical Illness, Hyperglycemia
Comparing Two Ways of Controlling Blood Sugar With Insulin in Patients Admitted to the Intensive Care Unit
The purpose of this study is to determine if there is any difference between two ways of controlling blood sugar with insulin. In patients admitted to the intensive care unit, blood sugar levels often rise due to the stress of…
- Trial name
- NCT00166491
- Testing
- Insulin
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- Mayo Clinic
Anxiety
Music for Anxiety in Critically Ill Patients
Rationale: Anxiety is common in critically ill patients, and has likely become more prevalent in the recent decade due to the imperative of the recent PADIS guidelines to use low levels of sedation and strive for wakefulness.
- Trial name
- RELACS (NCT04796389)
- Testing
- Music
- Where
- 3 sites in Netherlands
- Volunteers
- 104 people
- Sponsor
- Erasmus Medical Center
Critical Illness, Vitamin D Deficiency
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients
In the VITdAL-ICU trial using a large oral dose of vitamin D3 in 480 adult critically ill patients, there was no benefit regarding the primary endpoint hospital length of stay.
- Conditions
- Critical Illness, Vitamin D Deficiency, Covid19
- Trial name
- VITDALIZE (NCT03188796)
- Testing
- Cholecalciferol
- Where
- 18 sites in Austria, Belgium and 2 more
- Volunteers
- 2,400 people
- Sponsor
- Medical University of Graz
Postoperative Care, Intensive Care
Is There a Benefit of Postoperative ICU Management After Elective Surgery in Critical Ill Patients?
Postoperative care of high risk patients in the Intensive Care Unit (ICU) has for long been considered to be the gold standard of care in terms of reducing perioperative mortality.New evidence from a 7-day cohort study involving…
- Trial name
- NCT03777150
- Testing
- Postoperative care in Intensive care unit (ICU), Postoperative care in standard ward
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Saint Savvas Anticancer Hospital
Severe Sepsis, Septic Shock
(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis
This prospective randomized multicenter study evaluates whether the decision to prescribe antifungals guided by (1,3)-β-D-glucan in comparison to standard of care shortens time to antifungal therapy and reduces mortality in…
- Trial name
- CandiSep (NCT02734550)
- Testing
- Standard of care, (1,3)-β-D-glucan guided therapy
- Where
- 18 sites in Germany
- Volunteers
- 342 people
- Sponsor
- Center for Sepsis Control and Care, Germany