Clinical trials: Critical Ill Patients
Critically Ill
Testing of a New Therapeutic Vibration Device to Reduce Neuromuscular Weakness in Hospitalized Patients (Hospital Testing)
Objective: Test the ability of vibration to produce physiologic, biochemical, and anatomic changes consistent with exercise that would help prevent the development of muscle weakness that occurs when patients are immobile for…
- Trial name
- NCT05352100
- Testing
- Therapeutic Vibration Device
- Where
- United States
- Sponsor
- University of Michigan
COVID-19, Outcome, Fatal
Critically Ill ICU Patients Under Casirivimab- and/or Tocilizumab Application
In a retrospective observational study, critically ill COVID-19 patients admitted to the ICU with the CoV-2 delta-variant between august 2021 and february 2022 were evaluated (ethics application nr.
- Conditions
- COVID-19, Outcome, Fatal, Tocilizumab, Interleukin 6
- Trial name
- CasiTocCOVID (NCT06233357)
- Testing
- treated without (N), with casirivimab / imdevimab (C) or tocilizumab (T), solely, or in combination of both (C + T)
- Where
- Germany
- Volunteers
- 95 people
- Sponsor
- University of Ulm
Critically Ill, Acute Circulatory Failure
FLOTRAC/VIGILEO in Acute Circulatory Failure
Acute circulatory failure may be related to hypovolemia. Fluid loading increases stroke volume in approximatively half of challenges. Determining fluid responsiveness prevents unnecessary fluid loading.
- Conditions
- Critically Ill, Acute Circulatory Failure, Fluid Loading
- Trial name
- FLOVAC (NCT01090791)
- Testing
- Flotrac/Vigileo third generation software, Transthoracic echocardiography
- Where
- 2 sites in France
- Volunteers
- 1 people
- Sponsor
- Hôpital Européen Marseille
SIRS, Sepsis
Prevalence and Outcome of Hypermetabolism in Initial Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study
Patients in critical illness frequently present hypermetabolism， which can extremely increase the rest energy expenditure（REE）. We hypothesize that if we alleviate the extremely increased REE will improve ICU patients' outcome
- Conditions
- SIRS, Sepsis, Septic Shock
- Trial name
- NCT02002676
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Nanjing University School of Medicine
Critical Illness
The Optimization of Procedural Pain Control in Intensive Care Unit (ICU) Patients
The purpose of this study is to determine the influence of morphine 2,5 mg or morphine 7,5 mg iv during a painful and unavoidable intervention in critically ill patients.
- Trial name
- OPCIC (NCT00558090)
- Testing
- morphine
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Critically Ill, Mechanical Ventilation
The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))
This study is a prospective cohort study to evaluate the long-term effects of early activity and mobilisation compared to standard care on disability, function and health status for patients at 1, 2 and 5 years after recruitment…
- Conditions
- Critically Ill, Mechanical Ventilation, Long Term Outcome
- Trial name
- NCT05298982
- Testing
- Early activity and Mobilisation Intervention
- Where
- 16 sites in Australia
- Volunteers
- 250 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critical Illness
Mitochondrial Assessment in Critical Ill Patients in Intensive Care
Critically ill patients often require admission to the intensive care unit (ICU). When patients develop organ failures and end up on a ventilator, there are changes in the body's cell function that can increase the risk of poor…
- Trial name
- MitoICU (NCT07018843)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Critical Illness
Evaluation of Bedside Methods to Measure Muscularity in Critically Ill Patients
Muscle wasting is a significant problem in critically ill patients, with reported losses of a half to three percent per day over the first ten days (for an average 70kg person this equates to 3 to 20kg of muscle loss).
- Trial name
- NCT03019913
- Testing
- Observational cohort
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- La Trobe University
Acute Stress Disorder, Anxiety
GASA-CIR Trail (Guidance and the Symptoms of Acute Stress and Anxiety in Critically Ill Patients Relatives in Intensive Care Unit)
A randomized clinical trial 1:1 among relatives of patients admitted to an intensive care unit, the intervention group will be composed by family members who receive a printed brochure and will be encouraged to visit a website…
- Conditions
- Acute Stress Disorder, Anxiety, Depression
- Trial name
- GASA-CIR (NCT03812458)
- Testing
- website and brochure
- Where
- Brazil
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Critically Ill Patients, Neutropenic Fever Patients
Observational Prospective Study of the Predicted Value of Immature Thrombocytes Counts in Three Different Groups of Critically Ill Patients
Immature Platelet Fraction (IPF) is a new value in CBC blood tests Recent Studies showed that this value may be another prognostic factor in critically ill patients such as those admitted to ICU, or those with neutropenic Fever.
- Conditions
- Critically Ill Patients, Neutropenic Fever Patients, Patients With Hip Fractures
- Trial name
- NCT02016859
- Testing
- Immature Platelet Fraction
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Dr. Yishai Ofran
Infection
PCT and Clinical Algorithm for Determination of Duration of Antibiotics
Patients in the ICU whose infection is resolving will be randomized to standard duration of antibiotics compared to duration determined by a combination of a procalcitonin value and a simple evaluation of clinical status.
- Trial name
- NCT01572831
- Testing
- PCT and clinical algorithm for stopping abx
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Fraser Health
Critically Ill, Acute Kidney Injury
Remote Ischemic Preconditioning in Septic Patients
Acute kidney injury is a well-recognized complication in critically ill patients. Up to date there is no clinically established method to reduce the incidence or the severity of acute kidney injury.
- Conditions
- Critically Ill, Acute Kidney Injury, Sepsis
- Trial name
- RIPC-ICU (NCT05830669)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Universität Münster
Critical Illness, Enteral Nutrition
Optimizing Enteral Nutrition Regimen for Critically Ill Patients
Clinical Trial The goal of this clinical trial is to learn whether different enteral feeding cycles (18-hour, 20-hour, or standard 24-hour continuous feeding) improve outcomes for critically ill ICU patients who need tube…
- Conditions
- Critical Illness, Enteral Nutrition, Ventilator Associated Pneumonia, Hyperglycemia
- Trial name
- NCT07270939
- Testing
- 20-Hour Cycled Enteral Nutrition with a 4-Hour Fasting Window, 18-Hour Cycled Enteral Nutrition with a 6-Hour Fasting Window
- Volunteers
- 150 people
- Sponsor
- Hamad Medical Corporation
Effect of RBC Transfusions on Cerebral Oxygen Saturation
Monitoring the Effect of Red Blood Cell Transfusion on Cerebral Oxygen Saturation With Near Infrared Spectroscopy (NIRS) in Critically Ill Patients
Critically ill patients are frequently transfused with red blood cell (RBC) units with the predominant intention to increase arterial oxygen content and thus oxygen delivery to the tissues.
- Trial name
- NCT02232412
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Dietary Supplements, Intensive Care Unit
Vitamin D Supplementation in Intensive Care Unit Patients
A randomized controlled trial is designed to investigate the safety and clinical efficacy of a mega dose of VD in patients admitted in intensive care unit (ICU).
- Conditions
- Dietary Supplements, Intensive Care Unit, Vitamin D Deficiency, Vitamin D Toxicity
- Trial name
- NCT04915963
- Testing
- Vitamin D supplementation
- Volunteers
- 340 people
- Sponsor
- Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose
Therapeutic Drug Monitoring, Critical Illness
Pharmacokinetic of Posaconazole in Critically Ill Patients
The posaconazole pharmacokinetic in critically ill patients will be studied in a prospective, non-interventional, monocentric observational trial.
- Trial name
- NCT05275179
- Testing
- Posaconazole Therapeutic Drug Monitoring
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hyperglycemia, Respiratory Failure
A Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU
Poor glycemic control in critically ill patients can increase their mortality, while safe and efficient glucose control is laborious and time-consuming.
- Conditions
- Hyperglycemia, Respiratory Failure, Critical Illness
- Trial name
- NCT02491346
- Testing
- conventional empirical glycemic control, SGC directed glycemic control
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Peking Union Medical College Hospital
Community-acquired Pneumonia, Critical Illness
Point-of-Care Multiplex for Adult Patients With Severe Community-acquired Pneumonia
Clinical Impact on Point-of-Care Multiplex PCR Testing for Critically Ill Adult Patients With Community-acquired Pneumonia - A cluster randomization study in ICU units within one medical center.
- Trial name
- NCT04835818
- Testing
- Provide the panel report to the primary care physician
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Critically Ill
Therapeutic Monitoring of Vancomycin in Critical Ill Patients: a Registry
Vancomycin is a glycopeptide antibiotic that is the first line antibiotics for the treatment of serious gram-positive infections involving methicillin-resistant Staphylococcus aureus (MRSA).
- Trial name
- VCMTDMinCI (NCT02896218)
- Testing
- Pharmacists consultation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Withdrawal Syndrome, Iatrogenic Disease
AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU)
Withdrawal from opioids and sedatives administered for medical purposes (i.e. iatrogenic withdrawal) often goes unrecognized in the critically ill, but its prevalence is high.
- Trial name
- NCT04422808
- Where
- United States
- Volunteers
- 2,437 people
- Sponsor
- Wilkes University