Clinical trials: Critical Ill Patients
Critically Ill, Pain, Postoperative
Ketamine-fentanyl VS Fentanyl for Analgosedation in SICU
This is a randomized, double-blinded study to evaluate the analgosedative effect of ketamine in a surgical intensive care unit. The patients who will receive continuous fentanyl infusion for either pain control or sedation will…
- Trial name
- NCT03879564
- Testing
- Ketamine, Normal saline
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Mahidol University
Critical Illness, New Onset Atrial Fibrillation
Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients
A double-blind, multi-centre, randomized, placebo-controlled, feasibility pilot trial in the prevention of new onset atrial fibrillation of critically ill patients admitted to an ICU.
- Trial name
- ATOMIC (NCT05829317)
- Testing
- Magnesium sulfate
- Where
- 4 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Dr. Stephanie Sibley
Critical Illness
The Effect of Prophylactic Probiotic Lactobacilli in Enteral Feeding on Nosocomial Pneumonia Rates in Critically Ill Patients
To assess the effect of addition of probiotic Lactobacilli to standard enteral feeding on infection rates and feeding efficacy in critically ill patients.
- Trial name
- NCT00256087
- Testing
- Probiotic Lactobacillus, Lactose Powder
- Where
- Australia
- Volunteers
- 57 people
- Sponsor
- Melbourne Health
Citrulline, Organ Failure, Multiple
INtestinal Failure, multiPle Organ Failure ANd CItrulline Assessment
The gastrointestinal dysfunction occurs frequently during the intensive care unit (ICU) stay and is associated with a worse prognosis.
- Conditions
- Citrulline, Organ Failure, Multiple, Gastro Intestinal Failure, Intra Abdominal Pressure
- Trial name
- IN-PANCIA (NCT02520440)
- Testing
- Monitoring of plasmatic levels of Citrulline, Intra-abdominal pressure monitoring, Monitoring of plasmatic levels of Arginine and Glutamine
- Volunteers
- 42 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Acute Respiratory Failure, Critically Ill
Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim)
This is a study of plasma HBP -levels of a previously published trial of G-CSF in critically ill patients (Pettila et al. Critical Care Medicine 2000).
- Trial name
- HBP-Neupogen (NCT01713309)
- Testing
- Filgrastim
- Where
- Finland
- Volunteers
- 59 people
- Sponsor
- Helsinki University Central Hospital
Acute Respiratory Failure Requiring Mechanical Ventilation
Eye-Control Trial: Wearable Eye-Tracking Device as Means of Communication
The purpose of this study is to evaluate the feasibility of use of a wearable communication device for critically ill patients who are admitted to the intensive care unit (ICU) and mechanically ventilated.
- Trial name
- NCT04582149
- Testing
- EyeControl Eye-tracking Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Systemic Inflammatory Response Syndrome, Sepsis
Vitamin D and Critically Ill Patients
The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and…
- Trial name
- NCT01636232
- Where
- China
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Peripheral Venous Catheterization
Infrared for Peripheral Venous Catheterization in the Critically-ill
Peripheral venous catheterization is a fundamental part of the management of critically-ill patients, especially for administration of intravenous emergency treatments.
- Trial name
- ICARE (NCT03932214)
- Testing
- ACCUVEIN
- Where
- France
- Volunteers
- 460 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anemia
The Israeli Trigger for Blood Transfusions in the ICU
The purpose of the study is to determine the trigger for blood transfusions in Israeli ICU patients and the possible effects of anemia on the post ICU discharge course.
- Trial name
- NCT00413816
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Rabin Medical Center
AKI, Critical Illness
What is the Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients?
The aim of this study is to evaluate the impact of acute kidney injury (AKI) on the success rate, duration, and complications of weaning from mechanical ventilation in critically ill adult patients admitted to the intensive care…
- Trial name
- NCT07477652
- Testing
- Acute Kidney Injury (AKI) Exposure
- Volunteers
- 85 people
- Sponsor
- Assiut University
Pediatric Cancer, Critically Ill
ONCOTIPNET: Multicenter Study on Risk Factors and Outcome in Cancer Pediatric Patients Admitted in Italian PICUs
The study will describe characteristics of pediatric cancer patients admitted to Italian PICUs and will analyze risk factors of PICU admission, neurological outcome, and mortality.
- Trial name
- ONCOTIPNET (NCT04581655)
- Where
- 17 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera di Padova
Phosphate Deficiency, Hypophosphatemia
Protocolised Management of Phosphate Replacement Trial
The aim of this cluster, crossover, randomised controlled trial is to compare two standard arms of treatment for the replacement of phosphate in critically ill patients.
- Conditions
- Phosphate Deficiency, Hypophosphatemia, Protocol Optimization, Critical Care, Intensive Care
- Trial name
- PROMPT (NCT07288944)
- Testing
- Liberal Phosphate Replacement Protocol, Restrictive Phosphate Replacement Protocol
- Volunteers
- 2,400 people
- Sponsor
- Caboolture Hospital
Critical Illness
Self-Management Behaviors of Caregivers of the Chronically Critically Ill
For family members of chronically critically ill (CCI) patients, an ICU admission marks a significant milestone in the patient's illness trajectory that highlights the onset of end of-life issues and an abrupt need for family…
- Trial name
- ASSIST (NCT03065829)
- Testing
- ASSIST, Attention-Control
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Severe Burns, Acute Kidney Injury
Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT).
- Conditions
- Severe Burns, Acute Kidney Injury, Critical Illness
- Trial name
- CRRT-BURN (NCT07195565)
- Where
- Turkey (Türkiye)
- Volunteers
- 238 people
- Sponsor
- Pinar Timur Tasci
Critical Illness
Lithium Dilution Method in Guiding Fluid Therapy in Critically Ill Patients
Hypothesis: Fluid management guided by LiDCO doesn´t increase cumulative fluid balance and shorten organ dysfunction compared to fluid management based on CVP and clinical judgment.
- Trial name
- LIGA (NCT00626756)
- Testing
- LiDCO technology
- Where
- Czechia
- Volunteers
- 15 people
- Sponsor
- ASQA a.s.
Critically Ill
Enhanced Protein-Energy Provision Via the Enteral Route in Critically Ill Patients
Critically ill patients are consistently underfed. Feeding protocols are standardized system tools used to guide nutrition practices, but to date have failed to improve delivery of nutrition.
- Trial name
- PEPuP (NCT01167595)
- Testing
- PEP uP Protocol
- Where
- 18 sites in United States, Canada
- Volunteers
- 1,059 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Critical Illness, Fluid Overload
Intrarenal Venous Flow Change During Fluid Removal in Critically Ill Patients: A Prospective Exploratory Study
This clinical trial aims to study intrarenal venous flow patterns change, VExUS score change, and LUS score change during fluid removal treatment in critically ill patients
- Trial name
- NCT06216119
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Hyperglycemia, Hypoglycemia
Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients
The investigators intend to conduct a single-center, prospective, randomized comparative trial of patients admitted to the intensive care unit (ICU) who received continuous glucose monitoring (CGM) vs point of care (POC) glucose…
- Conditions
- Hyperglycemia, Hypoglycemia, Critical Illness, Diabetes Mellitus
- Trial name
- NCT05442853
- Testing
- Continuous glucose monitoring, Point of care glucose monitoring
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Malcom Randall VA Medical Center
Terminally Ill Patients
Mobile Shared Decision-Making Program for ICU Caregivers
By developing a smart mobile shared decision-making (SDM) model, this study aims to assist family members of critically ill end-stage patients in making appropriate decisions, enhance their decision quality, and evaluate the…
- Trial name
- NCT07469878
- Testing
- Experimental: Mobile technology devices
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- CHIA-HUI MA
Critical Illness, Stress Disorders, Traumatic, Acute
Intensiva 2.0: Improve the Communication Towards Families of Critically Ill Patients
The admission of a loved one in an ICU is a hard experience for family members. They frequently feel fear and grief, develop anxiety and depression symptoms, or even show some behaviors as this event was a real traumatic one…
- Conditions
- Critical Illness, Stress Disorders, Traumatic, Acute, Stress Disorders, Post-Traumatic
- Trial name
- Intensiva2 (NCT03438175)
- Testing
- Enhanced communication by brochure, website and posters
- Where
- Italy
- Volunteers
- 2,100 people
- Sponsor
- University of Milan