Clinical trials: Critical Ill Patients
Critical Illness
Responsiveness Index Versus the RASS Based Method for Adjusting Sedation in Critically Ill Patients
Systematic evaluation of pain, agitation and delirium in ICU-patients is recommended and deep sedation should be avoided. Sedation is still monitored with clinical assessments, like RASS.
- Trial name
- NCT03250481
- Testing
- Propofol
- Where
- Finland
- Volunteers
- 32 people
- Sponsor
- Helsinki University Central Hospital
Kidney Failure, Critically Ill
Hemodialysis Without Anticoagulation in Intensive Care Unit
The purpose of this study is to determine the safety and operative efficacy of intermittent hemodialysis without anticoagulation with saline flushes or Nephral 400ST in patients at high risk of bleeding
- Conditions
- Kidney Failure, Critically Ill, Hemorrhage
- Trial name
- NCT00242398
- Testing
- AN69 ST
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Départemental
Healthcare Associated Infection, Critically Ill
Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients
29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, with a significant proportion related to central venous catheters, and an influence on both morbility and mortality.
- Conditions
- Healthcare Associated Infection, Critically Ill, Central Venous Catheter Associated Bloodstream Infection
- Trial name
- OCT-BIO-CVC (NCT06216080)
- Testing
- D-FF-OCT analysis of CVC
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier William Morey - Chalon sur Saône
Post-Extubation Stridor
Use Bronchoscopy to Predict Post-Extubation Stridor in Critical Ill Patients
Our study aims at the accuracy of bronchoscopy to predict PES. Evidence base medicine guidelines for extubation may be obtained through this study.
- Trial name
- NCT00824096
- Testing
- Bronchoscopy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chimei Medical Center
Coma, Critical Illness
Effectiveness of Familiar Voices and Nature Sounds Among Critically Ill Comatose Patients
The goal of this clinical trial is to compare the effectiveness of auditory stimulation using familiar voices (FV) versus nature sounds (NS) on awakening critically ill comatose persons in the intensive care unit (ICU), reduce…
- Conditions
- Coma, Critical Illness, Unconsciousness
- Trial name
- NCT06470802
- Testing
- Familiar voice, Nature sounds, Control
- Where
- 2 sites in Vietnam
- Volunteers
- 90 people
- Sponsor
- Vo Thi Hong Nhan
Glucose Metabolism Disorders, Critical Illness
Effect of Location of Feeding on Glycemic Control in Critically Ill Patients (ELF)
The purpose of this study is to investigate the effect of location of feeding on glycemic control in critically ill patients. The investigators hypothesize that glycemic control in critically ill patients who receive enteral…
- Trial name
- ELF (NCT03566992)
- Testing
- Gastric
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Winchester Medical Center
Critical Illness, Intra-Abdominal Hypertension
Intraabdominal Pressure in Critically Ill Patients
This study is conducted to evaluate the incidence and prognostic significance of IAH in medical ICU patients.
- Trial name
- NCT03670771
- Testing
- Harrahill method for measuring of intraabdominal pressure
- Volunteers
- 100 people
- Sponsor
- Assiut University
Critically Ill, Ventilation Therapy; Complications
Consensus Statements on Airway Clearance Interventions in Intubated Critically Ill Patients--Protocol for a Delphi Study
Intubated critically ill patients are susceptible to secretion accumulation because of compromised airway clearance. Various airway clearance interventions are employed to prevent complication(s) arising from mucus retention.
- Conditions
- Critically Ill, Ventilation Therapy; Complications, Mucus Retention, Airway Clearance Impairment
- Trial name
- ACCorDingly (NCT06649734)
- Testing
- Delphi Study
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Feasibility of Virtual Reality Stimulation for Critically Ill Patients
Virtual Reality on the IMC
The goal of this substudy (main study NCT04498585) is to determine the feasibility of applying virtual reality stimulation to patients in the intermediate care unit.
- Trial name
- NCT05380700
- Testing
- Virtual Reality Stimulation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Critical Illness, Thrombosis
Influence of Vasopressors on Anti-Xa Activity in Critically Ill Patients
Critically ill patients require antithrombotic prophylaxis. At the same time, majority of them is receiving various vasopressors.
- Trial name
- NCT06055907
- Testing
- Serum anti-Xa activity
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Gdansk
Lung Diseases
Mathematical Arterialisation of Capillary Blood for Blood Gas Analysis in Critical Ill Patients
The aim of the study is to compare capillary blood gas analysis compensated by v-TAC software (aCBGE, aCBGF) to arterial blood gas analysis (ABG) in terms of pH, pCO2 and pO2 and the clinical usefulness of this method compared to…
- Trial name
- NCT04144296
- Testing
- Study procedure
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- RWTH Aachen University
Critical Illness, Hyperglycemia
Stress Hyperglycemia Ratio and Glucose Variability in Critically Ill Patients
This prospective cohort study aims to evaluate the stress hyperglycemia ratio and glucose variability among critically ill patients admitted to the intensive care unit.
- Trial name
- NCT07892222
- Volunteers
- 75 people
- Sponsor
- Assiut University
Muscle Weakness, Critical Illness
Pilot Study on Device-assisted Mobilisation of Critically Ill Patients
This Pilot study will hypothesize that patients with organ insufficiency and breathing assistance in our post-anaesthesia care unit (PACU) and ICU will be mobilized more often to an ICU mobility scale (IMS) ≥ 4 (i.e.
- Trial name
- LIANA-I (NCT05716451)
- Testing
- Device-assisted mobilisation with the sit/stand stabilizer Liana
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Acute Kidney Injury, Hemodialysis
Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients.
The purpose of this study is to compare the feasibility, safety and efficacy of hemodialysis with unfractionated heparin compared to hemodialysis with Citrasate in Critically Ill Patients.
- Trial name
- NCT01228292
- Testing
- Unfractionated heparin, Citrasate
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University Hospital, Antwerp
Critical Illness
Effect of Electrical Muscle Stimulation in Critically Ill Patients
Electrical muscle stimulation (EMS) is the therapy used to passively activate muscles using electrodes on the surface of the skin.
- Trial name
- NCT01637467
- Testing
- Electrical muscle stimulation (EMS)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Critical Illness, Extracorporeal Membrane Oxygenation Complication
PK/PD Study of Anti-Infective Drugs in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation Treatment
Extracorporeal membrane pulmonary oxygenation (ECMO) may provide partial or complete support for organ replacement in patients with severe cardiopulmonary failure, buying time for further management of the primary disease.
- Trial name
- ECMO (NCT06319677)
- Testing
- ECMO treatment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Third Xiangya Hospital of Central South University
COVID-19 Respiratory Infection
Respiratory Muscles Electromyography in Patients With Covid-19
This research was characterized as a cross-sectional observational study, following the recommendations of the STROBE instrument.
- Trial name
- EMG-COVID (NCT05572853)
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- University of Pernambuco
Kidney Injury, Acute
Effects of Continuous Veno-venous Haemofiltration on Plasma Lactate in Critically Ill Patients
Continuous Veno-Venous Hemofiltration (CVVH) can eliminate metabolic products effectively and replace renal function partly. It is widely used in intensive care units (ICUs), especially for patients with acute kidney…
- Trial name
- NCT01824771
- Testing
- Plasma lactate were measured
- Where
- China
- Volunteers
- 15 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hypomagnesemia, Critical Illness
Hypomagnesemia and Its Clinical Outcome
Magnesium is an essential electrolyte involved in numerous physiological processes, including maintaining cellular integrity, regulating muscle tone, supporting cardiovascular function, and modulating immune responses.
- Conditions
- Hypomagnesemia, Critical Illness, Intensive Care Unit (ICU) Patients, Scoring Systems
- Trial name
- Hypogamnesamia (NCT07089004)
- Testing
- No intervention (observational study)
- Where
- Bangladesh
- Volunteers
- 112 people
- Sponsor
- Bangladesh Bioscience Research Group
Hemodialysis
HEMOTOL: Efficacy and Safety of Hemodialysis On-line Monitoring Devices on Hemodynamic Stability in Intensive Care Unit
The purpose of this randomized controlled study is to compare the effects of different new dialysis on-line monitoring devices on hemodynamic stability during intermittent hemodialysis in critically ill patients with acute kidney…
- Trial name
- HEMOTOL (NCT00811109)
- Testing
- Standard Hemodialysis, with Blood Volume Management (BVM®) only, with Blood Volume (BVM®) and Temperature (BTM®) on-line monitoring
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen