Clinical trials: Critical Ill Patients
COVID-19, Encephalopathy
Acute Encephalopathy in Critically Ill Patients With COVID-19
Infection with SARS-CoV-2 or severe acute respiratory syndrome coronarvirus type 2 was highlighted in December 2019 in the city of Wuhan in China, responsible for an pandemic evolution since March 11, 2020.
- Conditions
- COVID-19, Encephalopathy, Critically Ill
- Trial name
- NeuroCOVID19 (NCT04320472)
- Testing
- Follow up
- Where
- 39 sites in United States, Brazil and 5 more
- Volunteers
- 250 people
- Sponsor
- Ictal Group
Critically Ill, Intubation Complication
Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
The aim of this retrospective cohort study is to compare the safety and efficacy of induction agents for tracheal intubation in critically ill adult patients.
- Conditions
- Critically Ill, Intubation Complication, Oxygenation, Airway Management
- Trial name
- NCT07222007
- Testing
- induction type for intubation in ICU
- Where
- United States
- Volunteers
- 806 people
- Sponsor
- Zeliha Alicikus
Critical Care, Phototherapy
HEaling LIght Algorithms for the ICU Patient
The purpose of this prospective, randomized controlled trial is to investigate if mechanically ventilated patients who are treated with a Light Scheduling Algorithm with high circadian effective irradiances are better able to…
- Trial name
- HELIA-ICU (NCT05556811)
- Testing
- Dynamic Light Therapy Device, LSA-1, Dynamic Light Therapy Device, LSA-2, Dynamic Light Therapy Device, LSA, 3
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Critically Ill
Indirect Calorimetry Versus Urea-creatinine Ratio to Evaluate Catabolism in Critically Ill Patients
This study aims to evaluate the efficiency of the urea/creatinine ratio as a catabolism marker compared to indirect calorimetry to optimize nutritional support in critically ill patients.
- Trial name
- NCT06244381
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Sao Domingos
Critical Illness
Reducing Discomforts in Critically Ill Patients: the IPREA3 Study
Since critically ill patients are exposed to stressful conditions, the investigators evaluated the effectiveness of a multicomponent program to reduce perceived discomforts in the Intensive Care Unit (ICU) .
- Trial name
- IPREA3 (NCT02442934)
- Testing
- Administration of the IPREA3 questionnaire, Immediate feedback through electronic reminder messages, Targeted interventions in each ICU to reduce discomforts
- Where
- 26 sites in France
- Volunteers
- 5,411 people
- Sponsor
- Dr Pierre KALFON
Critical Care
Neutrophil Lymphocyte Ratio as a Predictor of Outcome in Critically Traumatic Patients
Neutrophil lymphocyte ratio NLR is an important index that evaluate the inflammatory status . It is a cost effective and readily available , and simply calculated , so that why investigators try to use it as a predictor of short…
- Trial name
- NCT02749487
- Testing
- Neutrophil Lymphocyte Ratio
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Critical Illness, Enteral Nutrition
Early Enteral Feeding and Clinical Outcomes in ICU Patients
This study evaluated the effectiveness of an early enteral feeding protocol in critically ill adult patients admitted to an Intensive Care Unit (ICU).
- Conditions
- Critical Illness, Enteral Nutrition, Intensive Care Unit ICU, Nutritional Support
- Trial name
- EEFP (NCT07131098)
- Testing
- Early Enteral Feeding Protocol, Standard Nutritional Care
- Where
- Palestinian Territories
- Volunteers
- 80 people
- Sponsor
- Loai Muawiah Zabin
Critically Ill
Evaluation of Two Methods of Jejunal Placement of Enteral Feeding Tubes in Critically Ill Patients
In patients with high gastric residual volumes jejunal feeding is recommended. Jejunal feeding tubes can be placed in different ways.
- Trial name
- NCT00807287
- Testing
- Jejunal tube placement using the unguided frictional method, Jejunal tube placement using the endoscopic method
- Where
- Austria
- Volunteers
- 42 people
- Sponsor
- Medical University of Vienna
Venous Thrombosis, Critical Illness
The Effect of Vasopressors on the Anti Xa Response to Enoxaparin in Critically Ill Patients
The purpose of this study is to evaluate the efficacy of 3 different dosing regimens of enoxaparin in achieving adequate antithrombotic aFXa levels in critically ill patients.
- Trial name
- NCT00351663
- Testing
- Enoxaparine
- Where
- Israel
- Volunteers
- 39 people
- Sponsor
- Shaare Zedek Medical Center
Sedation in Critically Ill COPD Patients
Effects of Sedation on Clinical, Gasometric and Respiratory Muscle Parameters in Critically Ill COPD Patients
the investigators conducted a randomized controlled trial in respiratory intensive care unit (RICU) of Assiut University Hospital. COPD patients admitted to RICU were included.
- Trial name
- NCT03678532
- Testing
- Midazolam
- Volunteers
- 97 people
- Sponsor
- Assiut University
Sepsis, Thrombocytosis
Predictors of Reactive Thrombocytosis in Critically Ill Septic Patients
Reactive or secondary thrombocytosis is defined as abnormally high platelet count (≥4,50,000 platelets per micro-liter) in the absence of chronic myeloproliferative disease.
- Conditions
- Sepsis, Thrombocytosis, Critically Ill
- Trial name
- NCT03531515
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Gastrointestinal Dysfunction, Critical Illness
Ear-Vagus Nerve Stimulation and Body Acupuncture for Gut Motility in Elderly ICU Patients
This study aims to investigate whether acupuncture, specifically a combination of body acupuncture and ear vagus nerve stimulation (taVNS), can improve gastrointestinal function in critically ill elderly patients in the Intensive…
- Trial name
- NCT07861503
- Testing
- Standard Care, Body Acupuncture, Transcutaneous Auricular Vagus Nerve Stimulation
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Critical Care Nursing, Critical Illness
Clinical Trial Protocol for Continuous Glucose Monitoring in Critical Care
High blood glucose levels (hyperglycaemia) are very common in patients admitted to intensive care units (ICUs) and are associated with worse health outcomes.
- Conditions
- Critical Care Nursing, Critical Illness, Critical Care, Intensive Care, Hyperglycaemia
- Trial name
- CGM-UCI23 (NCT07687368)
- Testing
- Continuous Glucose Monitoring, Conventional Glucose Measurement
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
Nutrition Therapy for Critical Illness
An Observational Cohort Study to Establish Accurate Nutrition Therapy for Critically Ill Patients
1. Demographics data; 2. Nutritional evaluation data; 3. All biochemical monitoring data during the study period; 4. All nutritional treatment data will be recorded daily during the study period, including actual calorie intake…
- Trial name
- NCT02831725
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Pneumonia, Resistant Pneumonia
Flexible Bronchoscopy in Resistant Pneumonia in PICU
Pneumonia remains a leading cause of morbidity and mortality among critically ill children admitted to Pediatric Intensive Care Units (PICUs).
- Conditions
- Pneumonia, Resistant Pneumonia, Resistant Pneumonia in Critically Ill Pedaitric Patients
- Trial name
- FFP-RP PICU (NCT07421440)
- Testing
- Flexible fiberoptic bronchoscopy with bronchoalveolar lavage (BAL)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansour Gomaa Mohammed Saleh
Analgesia, Critical Illness
Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study
The aim of this prospective, randomized, active control, double blinded study is to assess the effect and safety of continuous infusion nefopam in mechanically ventilated ICU patients compared to standard of care.
- Conditions
- Analgesia, Critical Illness, Mechanical Ventilation, Sedation
- Trial name
- NCT05071352
- Testing
- Nefopam, Standard of care in the ICU for assessment and management of pain, sedation, and delirium.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
SIRS, Sepsis
Prevalence and Outcome of Hypermetabolism in Initial Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study
Patients in critical illness frequently present hypermetabolism， which can extremely increase the rest energy expenditure（REE）. We hypothesize that if we alleviate the extremely increased REE will improve ICU patients' outcome
- Conditions
- SIRS, Sepsis, Septic Shock
- Trial name
- NCT02002676
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Nanjing University School of Medicine
Critical Illness, ARDS
Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients
In this study, we will explore the feasibility of a randomized controlled trial that will compare high protein dose from ICU day 6 to 14 with moderate protein intake.
- Conditions
- Critical Illness, ARDS, Septic Shock, Multiple Trauma
- Trial name
- Replenish (NCT03480555)
- Testing
- Replenish Protein, Standard protein
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Abdullah International Medical Research Center
COVID, Sars-CoV2
Echocardiography in Critically-ill Patients With COVID-19 Pneumonia
Critical care echocardiography (CCE) has been widely used since the 10 last years. Covid outbreak leads that many patients with acute respiratory failure were admitted in the ICU.
- Trial name
- ECHO-COVID (NCT04414410)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Hospital Ambroise Paré Paris
Critical Illness
Family-Participatory Early Rehabilitation in Critically Ill Patients
This prospective, randomized controlled trial aims to evaluate the efficacy of an Internet-Based, Family-Participatory Early Rehabilitation (IFPER) model compared to standard care for critically ill patients in the Intensive Care…
- Trial name
- NCT07278713
- Testing
- Internet-Based, Family-Participatory Early Rehabilitation (IFPER), Standard ICU Care
- Where
- China
- Volunteers
- 204 people
- Sponsor
- The First Hospital of Hebei Medical University