Clinical trials: Critical Ill Patients
Critical Illness, Pain
Treatment of Procedural Pain Associated With Turning in Patients With Mechanical Ventilation
Background: Few studies have addressed the situation of procedural pain and the use of preemptive analgesia for turning in patients under mechanical ventilation.
- Trial name
- NCT01950000
- Testing
- Fentanyl
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Underdosing of Aminoglycosides, Critical Illness
An International Survey on Aminoglycoside Practices in Critically Ill Patients: AMINO III Survey
This is an international observational cohort study on current aminoglycoside practices in intensive care units. Clinical and demographic data, dosing and therapeutic drug monitoring data will be collected during the first week…
- Trial name
- NCT02850029
- Testing
- Observational study, no intervention
- Where
- 85 sites in Australia, Chile and 3 more
- Volunteers
- 964 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Critical Illness, Extracorporeal Membrane Oxygenation Complication
Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
Observational study Primary Objective: To study whether ECMO alters the PK of anti-infectives including voriconazole, posaconazole and caspofungin in critically ill patients on ECMO Secondary Objectives: Develop Population PK…
- Conditions
- Critical Illness, Extracorporeal Membrane Oxygenation Complication, Infection
- Trial name
- EAT-PK (NCT04674657)
- Testing
- blood drug concentration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Hyperglycemia
Effect of Real-time Continuous Glucose Monitoring on Glucose Control and Outcomes of Critically Ill Patients
The purpose of the study is to evaluate the effect of real-time continuous glucose monitoring system on glucose control and outcomes of critically ill patients.
- Trial name
- NCT01992965
- Testing
- Different methods of blood glucose monitoring between groups
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Kang Yan
Severe Pneumonia, Community-acquired Pneumonia
Efficacy of Intravenous Amboxol Hydrochloride as an Adjunct Therapy for Severe Pneumonia in Critically Ill Patients
Ambroxol is a mucolytic containing an active N-desmethyl metabolite of bromhexine. It is approved by both the U.S. FDA and EMA to be marketed under several formulations including oral, nasal, oro-mucosal, rectal and intravenous…
- Conditions
- Severe Pneumonia, Community-acquired Pneumonia, Hospital-acquired Pneumonia, Critical Illness
- Trial name
- NCT05663905
- Testing
- Ambroxol Hydrochloride, Standard Therapy
- Where
- Malaysia
- Volunteers
- 32 people
- Sponsor
- National University of Malaysia
Anemia, Critical Illness
Pharmacokinetic/ Pharmacodynamic Study of Epoetin Alfa (PROCRIT) in Critically Ill Patients.
The purpose of this study is to describe the pharmacokinetics (PK) of six different dosing regimens of epoetin alfa (PROCRIT®) in anemic critically ill subjects
- Trial name
- NCT00210756
- Testing
- epoetin alfa
- Volunteers
- 60 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Critical Illness, Muscle Atrophy
VALIDation of Bedside Ultrasound of Muscle Layer Thickness of the Quadriceps in the Critically Ill Patient
The overall objective is to evaluate the validity of bedside US of QMLT and MF-BIA by comparing measurements from US and MF-BIA to those estimates of lean body mass obtained from CT Scan of abdomen when done for clinical reasons.
- Trial name
- VALIDUM (NCT04676464)
- Testing
- Ultra- sound
- Volunteers
- 204 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Venous Thromboembolism
Efficacy of ICU-VTE Scale in ICU Patients
Venous thromboembolism (VTE) is a common cause of morbidity and mortality among critically ill patients. No uniform standard model of VTE risk for critically ill patients was formatted by now. In 2020, Viarasilpa et al.
- Trial name
- NCT05487066
- Where
- China
- Volunteers
- 269 people
- Sponsor
- Lijuan Zhang
Critical Illness, Respiratory Failure
Targeted OXYgen Therapy in Critical Illness
The investigators propose to conduct a feasibility, multi-centre, randomised controlled trial of targeted oxygen therapy in adult critically ill patients receiving mechanical ventilation via an endotracheal tube as part of their…
- Trial name
- TOXYC (NCT03287466)
- Testing
- Oxygen
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Critically Ill
The Effect of Gastric Antrum Ultrasonography on Early Stage of Enteral Nutrition in Critically Ill Patients.
The purpose of this study is to investigate the effect of Gastric Antrum Ultrasonography on Early Stage of Enteral Nutrition in Critically Ill Patients.
- Trial name
- NCT03539653
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Kang Yan
Anemic, Critically Ill Patients
Efficacy of Enteral Iron Supplementation in Critical Illness
The purpose of this study is to investigate the efficacy of enteral iron supplementation for improving anemia, decreasing the risk of blood transfusion, and decreasing mortality in patients who are hospitalized in the intensive…
- Trial name
- NCT00450177
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial
Critically ill people who need a breathing machine often develop hospital-acquired lung infections. These infections are commonly treated with the antibiotics piperacillin/tazobactam or meropenem.
- Conditions
- Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP), Nosocomial Respiratory Infection, Critical Illness
- Trial name
- ROAD-RCT (NCT07820501)
- Testing
- Resistance-Optimised Precision Dosing, Standard Care Dosing
- Volunteers
- 610 people
- Sponsor
- The University of Queensland
Critical Illness, Children
Early Versus Late Parenteral Nutrition in the Pediatric Intensive Care Unit
In the PEPaNIC trial it is investigated whether withholding parenteral nutrition during the first week in critically ill children is beneficial, compared to the current standard of the early start of parenteral nutrition.
- Trial name
- PEPaNIC (NCT01536275)
- Testing
- Late parenteral nutrition
- Where
- 3 sites in Belgium, Canada and 1 more
- Volunteers
- 1,440 people
- Sponsor
- KU Leuven
Critical Illness, Acute Respiratory Failure
Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)
The specific aim of the proposed study is to conduct a pilot study involving 160 critically-ill lean and obese patients enrolled at 11 sites in Canada, the United States of America, Belgium and France in order to: Specific Aims…
- Trial name
- TOP-UP (NCT01206166)
- Testing
- Olimel (5.7%E / N9E)
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 125 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Mortality, Muscle Loss
Mortality and Muscle Mass Loss in Critically Ill Patients.
The aim of the study is to monitor changes in muscle mass in critically ill patients and to verify whether a decrease in muscle mass of ≥10% during the first 7 days of hospitalization is associated with increased 28-day…
- Trial name
- MUSIC 2 (NCT07280039)
- Where
- Czechia
- Volunteers
- 386 people
- Sponsor
- Brno University Hospital
Shock, Critically Ill
Validation of the Fluid Responsiveness Index in Critically Ill Patients
Fluid therapy is an important part of the management of patients with hemodynamic instability in the intensive care unit. By increasing cardiac preload, it aims at elevating cardiac output (CO) and thus restoring hemodynamic…
- Trial name
- FRI (NCT00894309)
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 80 people
- Sponsor
- Bicetre Hospital
Acute Kidney Injury, Uremia
Timing of Renal Replacement Therapy in the Critically Ill Patients
Background: Severe acute kidney injury (AKI) among critically ill patients is sometimes treated with renal replacement therapy (RRT), and in Sweden continuous RRT (CRRT) is the dominant modality used in this population.
- Conditions
- Acute Kidney Injury, Uremia, Fluid Overload, Dialysis; Complications
- Trial name
- TORRT (NCT03629977)
- Testing
- CRRT
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska University Hospital
Covid-19, Critical Illness
MIcrovascular Dysfunction in CRitically Ill cOVID-19 Patients
Microcirculatory dysfunction appears to play a key role in the development of organ failure leading to the death of patients with coronavirus disease 2019 (Covid-19).
- Conditions
- Covid-19, Critical Illness, Hemodynamics, SARS-CoV Infection
- Trial name
- MICROVID (NCT04819802)
- Testing
- Measurement of sublingual microcirculation, Plasma sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
The Critically Ill Patient is Requiring Intubation, Septic Shock
Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation
The study is a prospective randomized controlled trial comparing the efficacy and safety of propofol-ketamine ("Ketofol") versus propofol monotherapy in geriatric ICU patients.
- Conditions
- The Critically Ill Patient is Requiring Intubation, Septic Shock, Pneumonia
- Trial name
- NCT07530146
- Testing
- Ketofol, propofol (drug)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Helwan University
Cognitive Impairment
Cerebrolysin in Critically Ill Patients With Delirium
Delirium is a severe problem in critically ill patients, and it is associated with increased morbidity, mortality, and extended stay in hospital. The pathophysiology of delirium is multifactorial and still poorly recognized.
- Trial name
- NCT06677502
- Testing
- Cerebrolysin, Saline Solution - IV
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Medical University of Lublin