Clinical trials: Critical Ill Patients
Side-effect of Antibiotic, Efficacy
Pharmacokinetics and Pharmacodynamics of Linezolid Continuous and Intermittent Administration
The purpose of this study is to evaluate the therapeutic efficacy expressed in pharmacokinetic/pharmacodynamic (PK/PD) indices, the clinical response and the risk of adverse reactions following the continuous and intermittent…
- Conditions
- Side-effect of Antibiotic, Efficacy, Pharmacokinetics, Critical Illness
- Trial name
- NCT05801484
- Testing
- Linezolid continuous infusion
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Cluj Municipal Clinical Hospital
Weaning Mechanical Ventilation, ICU Ill Patients
Diaphragmatic Ultrasonography in Difficult Weaning
Weaning from mechanical ventilation (MV) is a gradual process that includes several steps until the complete withdrawal of ventilatory support.
- Conditions
- Weaning Mechanical Ventilation, ICU Ill Patients, Diaphragm Dysfunction
- Trial name
- DUS-WEAN (NCT07751237)
- Testing
- Diaphragmatic ultrasound
- Where
- Brazil
- Volunteers
- 220 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Critical Illness
Vasopressor Support, Mean Arterial Pressure and Capillary Refill Time in Critically Ill Patients
The goal of this observational study is to learn whether different doses of various vasopressor drugs influence capillary refill time (CRT) value in crtically ill patients.
- Trial name
- NCT05674084
- Testing
- Capillary refill time
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Silesia
Critically Ill Patients
Influence of Tightly Glucose Control on Hyperglycemic Toxicity and Protein Catabolism in Critically Ill Patients
To compare the differences of urinary nitrogen excretion, nitrogen balance and clinical outcomes between tightly insulin therapy and conventional insulin therapy in the ICU.
- Trial name
- NCT01227148
- Testing
- Tightly glucose control, Conventional glucose control
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Tube Feeding
Incidence of Diarrhea Using High and Low Osmolality Enteral Tube Feeding in Critically Ill Surgical Patients
The purpose and primary objective of this study is to determine if there is an association between enteral tube feed (TF) osmolality and diarrhea in critically ill patients.
- Trial name
- NCT03487744
- Testing
- Osmolite 1.5, Promote without fiber
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Critical Illness, Malnutrition
The Effect of Higher Protein Dosing in Critically Ill Patients
The investigator will investigate the effects of higher protein/amino acid dosing (≥2.2 g/kg/d) vs usual protein/amino acid dosing (≤1.2 g/kg/d) on clinical outcomes in nutritionally high risk ill patients.
- Trial name
- EFFORT (NCT03160547)
- Testing
- Usual Protein/Amino Acid Group, Higher Protein/Amino Acid Group
- Where
- 86 sites in United States, Argentina and 14 more
- Volunteers
- 1,329 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Intensive Care Unit Syndrome
Correlation of the Hand Grip Force With Maximum Inspiratory and Maximum Expiratory Pressure, in Critical Ill Patients
This study aimed to examine the relationship between Hand Grip Force (HGF), Maximum Inspiratory Pressure (PImax) and Maximum Expiratory Pressure (PEmax) in ICU tracheostomized patients.
- Trial name
- NCT03457376
- Testing
- Hand Grip Force, Maximal Inspiratory Pressure, Maximal Expiratory Pressure
- Where
- 2 sites in Greece
- Volunteers
- 15 people
- Sponsor
- Attikon Hospital
Pressure Ulcer, Critical Care
Prevalence of Pressure Ulcers Among Critically Ill Patients and Factors Associated With Their Occurrence in the ICU
The prevalence of and risk factors for pressure ulcers (PUs) in critically ill patients have been poorly studied. The main objective of this study was to describe the prevalence of PUs in critically ill patients.
- Conditions
- Pressure Ulcer, Critical Care, Intensive Care Unit Syndrome
- Trial name
- PRESSURE (NCT03912467)
- Testing
- Pressure Ulcer Evaluation
- Where
- 60 sites in France
- Volunteers
- 1,228 people
- Sponsor
- French Society for Intensive Care
Enteral Nutrition, Vasopressor Agents
Enteral Nutrition and Vasoactive Drugs
Enteral nutrition in critically ill patients undergoing vasoactive support due to hemodynamic instability is controversial. Hypothesis: enteral nutrition delivered in such patients can be feasible and safe.
- Conditions
- Enteral Nutrition, Vasopressor Agents, Hemodynamics Instability, Critical Care
- Trial name
- NUTRIVAD (NCT03401632)
- Testing
- Enteral nutrition
- Where
- 23 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Severo Ochoa
Hyperglycemia
Fat Based Enteral Nutrition for Blood Glucose Control in ICU
In this randomized, double-blind clinical trial, eligible hospitalized ICU patients with EN will be included. Patients will be divided into two groups.
- Trial name
- NCT02584907
- Testing
- High Fat Enteral Nutrition
- Where
- Iran
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Critical Illness
Hyporesponsiveness of Natural Killer Cells and a Dysfunctional Inflammatory Response in Critically Ill Patients
To investigate natural killer (NK) cell activities, circulating cytokine levels and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients.
- Trial name
- NCT02565589
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Near-infrared Vision, Machine Learning
Near-infrared Vision for Microcirculatory Status
The investigators aimed to combine the image of near-infrared vision and machine learning method to evaluate the microcirculatory status of critical ill patients.
- Conditions
- Near-infrared Vision, Machine Learning, Microcirculatory Status
- Trial name
- NVIM (NCT04399811)
- Testing
- Near-infrared Vision Photograph
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Critical Illness, Vitamin D Deficiency
VITdAL@ICU - Correction of Vitamin D Deficiency in Critically Ill Patients
Study hypothesis: High-dose vitamin D leads to a shorter hospital stay in critically ill patients Vitamin D deficient patients will be randomized to receive either 540,000 IU cholecalciferol or placebo.
- Trial name
- VITdAL@ICU (NCT01130181)
- Testing
- Cholecalciferol
- Where
- Austria
- Volunteers
- 480 people
- Sponsor
- Harald Dobnig, MD
Transfusion Related Complication, Critical Illness
West-China Transfusion Score for Critically-ill Patients
Guidelines for blood transfusion have been issued for years. According to these guidelines, red blood cells (RBCs) transfusion should be given when the hemoglobin level is less than 6g/dL or 7g/dL and is unnecessary when the…
- Trial name
- NCT02139995
- Testing
- RBC transfusion based on different protocols
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Anemia, Critically Ill
Survey of Blood Transfusion Practices in Critically Ill Patients at High Altitude
The purpose of this study is to describe current practice on red blood cell transfusion in critically ill patients of intensive care units located in high altitude areas
- Trial name
- NCT03019900
- Testing
- Red blood cells transfusions
- Where
- Ecuador
- Volunteers
- 352 people
- Sponsor
- Universidad Tecnológica Equinoccial
Critical Illness, Enteral Nutrition Intolerance
Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients
This study aims to explore the correlation between gastrointestinal blood flow and the incidence of enteral nutrition intolerance (ENI) and its symptoms in critically ill patients, construct and compare predictive models…
- Conditions
- Critical Illness, Enteral Nutrition Intolerance, Enteral Nutrition Feeding, Prediction Models
- Trial name
- NCT07521111
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Cancer, Critically Ill
Protein Intake Associated With Physical Activity Related to Specific Outcomes
This is a Randomized Controlled Trial . The purpose of this study is to assess the hypothesis that whether a high protein diet combined with a physical activity protocol in surgical cancer patients admitted to the ICU in the post…
- Conditions
- Cancer, Critically Ill, Surgery
- Trial name
- STRENGTH (NCT03438201)
- Testing
- Intervention, Control
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- University of Sao Paulo
Catheter-Related Infections
Comparison of Chlorhexidine Impregnated Dressing and Standard Dressing
Investigators have designed a single-center randomized controlled trial to compare chlorhexidine gluconate (CHG)-impregnated dressing and standard dressing with respect to their effects on the infection outcomes.
- Trial name
- NCT04794231
- Testing
- Standard dressing, Chlorhexidine gluconate -impregnated dressing group
- Where
- Turkey (Türkiye)
- Volunteers
- 307 people
- Sponsor
- Istanbul Medeniyet University
Acute Gastrointestinal Injury, Critical Illness
Correlation Between Acute Gastrointestinal Injury and Venous Return in Critical Ill Patients
Currently, altered intestinal blood flow in critically ill patients has been a hot research topic in recent years. In 2022, studies on acute mesenteric ischemia were published in top journals in critical care medicine [Crit Care…
- Trial name
- NCT06667297
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Critical Illness, Fluid Overload
Fluid Balance and Body Weight Changes in Critically Ill Adult Patients
Positive fluid status has been consistently associated with worse prognosis in critically ill adult patients.However, observational studies showed poor agreement between fluid balance and body weight changes.
- Trial name
- NCT04434079
- Testing
- Regular critical care
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- Hospital de Clinicas de Porto Alegre