Clinical trials: Critical Ill Patients, open to volunteers
Fluid Overload
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit.
- Trial name
- GODIF (NCT04180397)
- Testing
- Furosemide, Isotonic saline
- Where
- 29 sites in Australia, Czechia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Morten H. Bestle
Critical Illness, Recovery Outcomes
Improving Survivorship for Critically Ill Patients Aged 65 and Over
IMPROVE-65 is a randomised control trial designed specifically for people aged over 65 who have survived critical illness. It aims to support patients and general practitioners by providing timely, personalised information to…
- Conditions
- Critical Illness, Recovery Outcomes, Care Coordination
- Trial name
- IMPROVE-65 (NCT07175961)
- Testing
- Multicomponent telehealth care coordination
- Where
- 2 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Psychological Disorder, Critical Illness
Feasibility and Preliminary Effects of a Spiritual Care Strategy on Psychological Disorders in Critically Ill Patients
Studies in hospitalized patients have shown that a large percentage of them consider religion or spirituality to be an important factor in enabling them to cope with a serious illness.
- Trial name
- NCT06048783
- Testing
- Program of systematic and periodic spiritual accompaniment and care
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Post-Intensive Care Syndrome (PICS)
Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients
Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple comorbidities although a poor…
- Trial name
- TOPICS (NCT07170527)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- ARH van Zanten, MD PhD
Metabolism and Nutrition Disorder
Amino Acid Metabolism in Fed Surgical Critically Ill Patients
Introduction Sarcopenia is defined as progressive generalized loss of skeletal muscle mass, strength and function. Sarcopenia due to lack of physical activity is a known phenomenon and is usually observed as a normal part of…
- Trial name
- NCT03451968
- Testing
- amino acid tracer injection for metabolism analysis
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Delirium
Melatonin for Treatment of Delirium in Critically Ill Adult Patients
The purpose of this study is to determine the feasibility of conducting a randomized controlled trial (RCT) with melatonin for treatment of delirium in critically ill adult patients.
- Trial name
- DELIRE-ICU (NCT05713877)
- Testing
- Melatonin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Cancer, Critical Care, Cancer Critically Ill
Admission, Triage, and Discharge Criteria for Oncological Patients in the Intensive Care Unit
This study will create one agreed set of rules to help doctors decide which people with cancer should be treated in an intensive care unit (ICU), and when they are well enough to leave it.
- Trial name
- ONCO-TRIAD (NCT07809490)
- Testing
- No Intervention: Observational Cohort
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Onco Critical Care Society
Respiration Failure, Cardio Vascular Disease
COMPARE-VENT Feasibility Pilot Study
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20%…
- Conditions
- Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness
- Trial name
- NCT07656259
- Testing
- Volume Controlled Mode, Pressure Controlled Mode
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Fluid Balance, Acute Kidney Injury
Fluid Balance in Acute Kidney Injury in Critically Ill Patients
This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults.
- Conditions
- Fluid Balance, Acute Kidney Injury, Critically Ill Acute Kidney Injury, Critically Ill
- Trial name
- NCT07338734
- Volunteers
- 120 people
- Sponsor
- Assiut University
Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial
Critically ill people who need a breathing machine often develop hospital-acquired lung infections. These infections are commonly treated with the antibiotics piperacillin/tazobactam or meropenem.
- Conditions
- Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP), Nosocomial Respiratory Infection, Critical Illness
- Trial name
- ROAD-RCT (NCT07820501)
- Testing
- Resistance-Optimised Precision Dosing, Standard Care Dosing
- Volunteers
- 610 people
- Sponsor
- The University of Queensland
Critical Illness
Mitochondrial Assessment in Critical Ill Patients in Intensive Care
Critically ill patients often require admission to the intensive care unit (ICU). When patients develop organ failures and end up on a ventilator, there are changes in the body's cell function that can increase the risk of poor…
- Trial name
- MitoICU (NCT07018843)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Enteral Feeding Intolerance, Critical Illness
Continuous Versus Intermittent Enteral Feeding and Gastric Residual Volume in Critically Ill Patients
This study will compare two commonly used methods of enteral feeding in critically ill adults: continuous feeding and intermittent feeding.
- Trial name
- NCT07876141
- Testing
- Continuous Enteral Feeding, Intermittent Enteral Feeding
- Where
- Vietnam
- Volunteers
- 76 people
- Sponsor
- Viet Duc University Hospital
Parenteral Nutrition, Gastroparesis
Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction
Clear study hypothesis / research question It has already been proven that a prolonged negative energy balance during intensive care stay is an independent risk factor for mortality.
- Conditions
- Parenteral Nutrition, Gastroparesis, Gastrointestinal Dysfunction, Protein Deficiency
- Trial name
- ATTAINMENT (NCT06510348)
- Testing
- Supplemental Parenteral Nutrition (SPN)
- Where
- Romania
- Volunteers
- 164 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
AKI, Critical Illness
What is the Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients?
The aim of this study is to evaluate the impact of acute kidney injury (AKI) on the success rate, duration, and complications of weaning from mechanical ventilation in critically ill adult patients admitted to the intensive care…
- Trial name
- NCT07477652
- Testing
- Acute Kidney Injury (AKI) Exposure
- Volunteers
- 85 people
- Sponsor
- Assiut University
Critically Ill, Mechanical Ventilation
The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))
This study is a prospective cohort study to evaluate the long-term effects of early activity and mobilisation compared to standard care on disability, function and health status for patients at 1, 2 and 5 years after recruitment…
- Conditions
- Critically Ill, Mechanical Ventilation, Long Term Outcome
- Trial name
- NCT05298982
- Testing
- Early activity and Mobilisation Intervention
- Where
- 16 sites in Australia
- Volunteers
- 250 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Transfusion-Related Acute Lung Injury, ARDS, Human
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples
Transfusion-related acute lung injury (TRALI) is a severe complication of blood transfusions. After a transfusion, TRALI develops in 0.08-15% of cases depending on the characteristics of the studied population.
- Trial name
- CURIE (NCT06444750)
- Testing
- Blood sample collection
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar