Clinical trials: Critical Illness
Covid19, Endothelial Dysfunction
Managing Endothelial Dysfunction in Critically Ill COVID-19 Patients at LAUMCRH
COVID-19 Infection has been found to cause endothelial dysfunction and most of the adverse events stem to this mechanism. So we seek to target endothelial dysfunction in critically Ill patients with covid by giving them an…
- Trial name
- NCT04813471
- Testing
- Endothelial Protocol
- Where
- Lebanon
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Lebanese American University Medical Center
Sepsis, Primary Myopathies
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular…
- Trial name
- NCT00735384
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Colonic Neoplasms, Rectal Neoplasms
Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy
Indications for colostomy are rectal or anal cancer, diverticular disease, radiation enteritis, complex perirectal fistulas, anorectal trauma, severe incontinence, motility and functional disorders.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Fecal Incontinence
- Trial name
- EACC (NCT02308631)
- Testing
- ENDOSCOPICALLY ASSISTED COLOSTOMY WITH COLOPEXY
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiogenic Shock,, With ECMO or IABP Support,
The Analysis of Heart Rate Variability With 24hrs Holter ECG and Serum Cardiac Fibrosis Markers in Critical Illness Patients Who Are With Cardiogenic Shock, With ECMO or IABP Support, or With APACH II Score >25)
The study is to show the prognostic factor of HRV parameter and cardiac fibrosis markers in critical illness patients
- Conditions
- Cardiogenic Shock,, With ECMO or IABP Support,, With APACH II Score >25)
- Trial name
- NCT01993745
- Where
- Taiwan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pseudomonas Infections, Pseudomonas Septicemia
Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis
The present study focuses on patients with Pseudomonas aeruginosa (PSA) sepsis. The aim of the present study is to find out whether the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype predominates in blood monocytes in…
- Conditions
- Pseudomonas Infections, Pseudomonas Septicemia, Pseudomonas; Pneumonia, Pseudomonal Bacteraemia
- Trial name
- MIPSA (NCT03044223)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulm
ICU Stay & Mortality
Observational, Prospective, Single-center Study: Should Body Mass Index (BMI) be Added to the Scoring Criteria of Hepatic Critically Ill Patients in Intensive Care Unit??
The purpose of the study is to evaluate the hypothesis of poor clinical outcomes in critically ill patients that are having abnormal BMI.
- Trial name
- NCT03461523
- Where
- Egypt
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Critical Illness, Family
Psychosocial Outcomes in Families of COVID-19 ICU Patients
During the first part of the SRAS-COV2 pandemic, families were not allowed to visit the patients in ICU. We know that families can develop "Family-PICS" after their relatives' ICU stay.
- Conditions
- Critical Illness, Family, Psychological Stress, Covid19
- Trial name
- NCT04498507
- Testing
- HADS questionnaire
- Where
- Belgium
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Liege
Malnutrition, Critical Illness
Anabolic Steroids for Nutritional Rehabilitation of Critically Ill Patients
This prospective, double-blinded study will determine the feasibility of determining the efficacy of a weekly intramuscular injection of nandrolone (an anabolic steroid) in malnourished ICU patients.The data from this study will…
- Trial name
- NCT00242463
- Testing
- Nandrolone (anabolic steroid)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Critical Illness
Nutrient Uptake During Continuous Enteral Feeding
Continuous enteral nutrition is used to feed patients in intensive care who are unable to eat normally. The goal of this observational study is to learn about the uptake of nutrients from feeding formula.
- Trial name
- NCT05628844
- Testing
- Continuous enteral feeding
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Felix Liebau
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Volume Overload, Tissue Perfusion
Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness
43 patients between 18-60 years presenting with criteria of sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection, suspected or documented infection and an acute increase ≥2 SOFA…
- Trial name
- NCT05104528
- Testing
- OSYPKA Medical ICONTM Noninvasive CardiometerTM Model C3, Fujifilm Sonosite M-Turbo C Ultrasound system
- Where
- Egypt
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Critical Illness, Gender Equality
Ethnic and Gender Based Admittance Patterns in the ICU
The dominating proportion of patients in the ICU are men. Studies indicate that men receive more mechanical ventilation, vasoactive drugs, renal replacement therapy, invasive monitoring and have longer length of stay in the ICU.
- Conditions
- Critical Illness, Gender Equality, Discrimination, Sex, Discrimination, Racial
- Trial name
- EGAP-ICU (NCT05513456)
- Testing
- Randomization to a different factors in the case descriptions
- Where
- Sweden
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Pediatric, Critical Illness
Examining Health Literacy in Biorepository Consents
Previous research has shown that most parents would allow their child's leftover blood to be included in a de-identified biorepository using opt-out consent in an outpatient setting.
- Conditions
- Pediatric, Critical Illness, Consent
- Trial name
- NCT04953169
- Testing
- Biobank Video, Non-Video
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Intellectual Disability, Perceptual Disorders
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood
The purpose of this study is to determine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes.
- Conditions
- Intellectual Disability, Perceptual Disorders, Memory Disorders
- Trial name
- RESTORE-cog (NCT02225041)
- Where
- 31 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Status Epilepticus
Status Epilepticus in the Critically Ill Patients
Convulsive and Non Convulsive Status Epilepticus (SE) and Pseudo Status Epilepticus prospective registry. Data collection using a standardized form : demographic data and data related to the SE, including circumstances of onset…
- Trial name
- NCT03457831
- Where
- 20 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ictal Group
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Intubation; Difficult or Failed, Intubation Complication
Expert Consensus Statements for the Management of a Physiologically Difficult Airway Using the Delphi Method (PDADelphi)
The aim of this study is to review/identify the existing definition and management strategies for a physiologically difficult airway (PDA), to generate expert consensus on the various aspects of managing a patient with a PDA…
- Conditions
- Intubation; Difficult or Failed, Intubation Complication, Hemodynamic Instability, Critical Illness
- Trial name
- PDADelphi (NCT05762068)
- Testing
- Delphi procedure
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Airway Management, Tracheal Intubation
Curriculum for Airway Skills in Critically Ill Adults: a Delphi Evaluation
This study using a Delphi methodology, and involving international experts, will help define a training curriculum for physicians involved with airway management in critically ill patients.
- Conditions
- Airway Management, Tracheal Intubation, Critical Illness, Training
- Trial name
- CASCADE (NCT06689748)
- Testing
- Delphi procedure
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pediatric ALL, Critical Illness
Singapore's Health Outcomes After Critical Illness in Kids
What is the problem? Every year about 2.5 million children are affected by critical illness and require admission to the pediatric intensive care unit (PICU).
- Conditions
- Pediatric ALL, Critical Illness, Post Intensive Care Unit Syndrome
- Trial name
- SHACK (NCT04637113)
- Testing
- This is a non-interventional study
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital