Clinical trials: Critical Illness, completed
Fluid Shifts, Critical Care
Effects of Fluid Balance Control in Critically Ill Patients
Most ICU patients develop a positive fluid balance, mainly during the two first weeks of their stay. The causes are multifactorial: a reduced urine output subsequent to shock state, positive pressure mechanical ventilation, acute…
- Trial name
- POINCARE (NCT02765009)
- Testing
- diuretics, albumin, fluid restriction
- Where
- 11 sites in France
- Volunteers
- 1,411 people
- Sponsor
- Central Hospital, Nancy, France
Ventilation Therapy; Complications
Correlation Between Muscle Thickness and Inflammation With Ventilator Use in Critically Ill Patients
Decrease thickness of diaphragm muscle, cross-sectional area of rectus femoris and biceps brachii muscle, and increase in CRP would affect ventilator length of use in critically ill patients in ICU
- Trial name
- NCT03933332
- Testing
- Diaphragm thickness, Cross-sectional area of rectus femoris muscle, Cross-sectional area of biceps brachii
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Critical Illness
Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)
Many patients in intensive care (ICU) need help to breathe on a breathing machine and need pain killers and sedatives to keep them comfortable and pain free.
- Trial name
- A2B (NCT03653832)
- Testing
- Dexmedetomidine, Clonidine, Propofol
- Where
- 38 sites in United Kingdom
- Volunteers
- 1,404 people
- Sponsor
- University of Edinburgh
Respiratory Insufficiency, Ventilator Weaning
Totally Transdermal Sedation in the Weaning From Remifentanil Infusion
The choice of the sedation protocol has a massive impact on the duration of mechanical ventilation and the timing of extubation. Many sedation protocols are described in the literature.
- Conditions
- Respiratory Insufficiency, Ventilator Weaning, Analgesics, Opioid
- Trial name
- TOES (NCT04204967)
- Testing
- Fentanyl Transdermal System, Remifentanil
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Kidney Injury
Role of Biomarkers in Predicting Contrast-induced Acute Kidney Injury in Critically Ill Patients
Title: "Role of biomarkers in predicting contrast-induced acute kidney injury in critically ill patients: a prospective observational study" Objective: To analyse the role of plasma and urinary biomarkers (Neutrophil…
- Trial name
- NCT02430844
- Where
- India
- Volunteers
- 85 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Anemia, Mechanical Ventilation
Anemia and Duration of Mechanical Ventilation
In mechanically ventilated patients in intensive care unit, anemia is commonly seen and it is probably associated with adverse outcomes including mortality.
- Conditions
- Anemia, Mechanical Ventilation, Critically Ill, Intensive Care Unit
- Trial name
- NCT05382065
- Where
- Thailand
- Volunteers
- 236 people
- Sponsor
- Mahidol University
Critical Illness, Respiratory Failure
Early Versus Deferred De-escalation From Controlled Ventilation After a 48-Hour Landmark of Physiological Stability
This retrospective target trial emulation evaluates the optimal timing of de-escalation from controlled to assisted mechanical ventilation in critically ill adults.
- Conditions
- Critical Illness, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT07804992
- Testing
- Ventilatory Support De-escalation Strategy
- Where
- China
- Volunteers
- 12,736 people
- Sponsor
- Ruijin Hospital
Hypomagnesemia
Magnesium Replacement Therapy to Prevent Acute Renal Failure in Critically Ill Patients
Acute renal failure (ARF) is a serious and common complication in hospitalized patients, occurring in more than 25% of intensive care unit (ICU) patients.
- Trial name
- NCT01700998
- Testing
- Magnesium
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Coronavirus Infection
Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19
Multicenter observational/registry study of the clinical features and outcomes of critically ill patients with COVID-19.
- Trial name
- STOP-COVID (NCT04343898)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 5,154 people
- Sponsor
- Brigham and Women's Hospital
Sepsis, Critical Illness
Methionine Metabolism in Enterally Fed Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis…
- Trial name
- NCT01889264
- Testing
- Observational
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Critical Care, Mechanical Ventilation
Prevention of Ventilator Associated Pneumonia With Toothbrushing in Oral Care of Critically Ill Mechanically Ventilated Patients
Effect of toothbrushing in oral care of mechanically ventilated critically ill patients on prevention of ventilator associated pneumonia
- Conditions
- Critical Care, Mechanical Ventilation, Ventilator Associated Pneumonia Prevention, Toothbrushing
- Trial name
- NCT02400294
- Testing
- Toothbrushing
- Where
- France
- Volunteers
- 2,030 people
- Sponsor
- University Hospital, Clermont-Ferrand
Anemia, Critical Illness
Practical Anemia Bundle for SusTained Blood Recovery
The purpose of this study is to test a multi-faceted anemia treatment plan to reduce the severity of anemia and to promote hemoglobin and functional recovery in adults who have been in the intensive care unit (ICU).
- Trial name
- PABST-BR (NCT05167734)
- Testing
- Iron Dextran, Erythropoietin (EPO)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Critical Illness
Family Care Conferences Criteria in the Pediatric Intensive Care Unit
Multidisciplinary experts from two Pediatric Intensive Care Units (PICUs), used an iterative modified Delphi process to develop and refine criteria for determining PICU patients for whom a family care conference would be…
- Trial name
- NCT04298281
- Where
- 2 sites in United States
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Critical Illness, Sepsis
Does GM-CSF Restore Neutrophil Phagocytosis in Critical Illness?
Despite the introduction of multiple preventative measures rates of hospital acquired infection in the intensive care unit remain high. New approaches to tackling this problem are required.
- Conditions
- Critical Illness, Sepsis, Immuno-suppression
- Trial name
- GMCSF (NCT01653665)
- Testing
- Leukine, Normal Saline
- Where
- 4 sites in United Kingdom
- Volunteers
- 64 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Adrenal Insufficiency, Critical Illness
Pilot Study Assessing Oxidative Stress in Children
Role fo oxidative stress in adrenal insufficiency has not been studied. The degree of oxidative stress and it's role in pediatric critical illness is unknown.
- Trial name
- OxStress (NCT01052207)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Emory University
Critically Ill
Continuous Control of Tracheal Cuff Pressure and Microaspiration in Critically Ill Patients
We hypothesized that continuous control of tracheal cuff pressure would reduce microaspiration of gastric content as determined by pepsin level in tracheal aspirate.
- Trial name
- NCT01082666
- Testing
- Continuous control of cuff pressure, Manual control of cuff pressure
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Lille
Fungal Prophylaxis, Candida Infection
Antifungal Prophylaxis in Intensive Care Unit (ICU) Patients
Purpose. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonization and infection. However, Candida prophylaxis in intensive care unit (ICU) is still a matter of debate. Methods.
- Conditions
- Fungal Prophylaxis, Candida Infection, Critical Illness, Surgery
- Trial name
- NCT01495039
- Testing
- Nystatin
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- Policlinico Hospital
Critically Ill
Bio-electrical Impedance Analysis Derived Parameters for Evaluating Fluid Accumulation
The purpose of this study is to assess fluid accumulation (FA) in the body using BIA (Bioelectrical Impedance Analysis) in critically ill patients treated in the ICU.
- Trial name
- NCT05961631
- Testing
- Bio-electrical Impedance Analysis
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Universitas Indonesia
Respiratory Insufficiency
Impact of the Assisted Ventilation Mode on Diaphragm Efficiency in Critically Ill Patients
This study evaluates the impact of the assisted mode of mechanical ventilation on diaphragm efficiency in mechanically ventilated critically ill patients.
- Trial name
- NAVA_PSV (NCT02473172)
- Testing
- Pressure Support ventilation, Neurally Adjusted Ventilatory Assist
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Bari
Intensive Care Unit, Muscle Weakness
Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness
The purpose of this study is to investigate whether neuromuscular electrostimulation (NMES) will decrease ICU-associated weakness.
- Trial name
- NMES (NCT00709124)
- Testing
- Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
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