Clinical trials: Critical Illness, completed
Enteral Nutrition, Vasopressor Agents
Enteral Nutrition and Vasoactive Drugs
Enteral nutrition in critically ill patients undergoing vasoactive support due to hemodynamic instability is controversial. Hypothesis: enteral nutrition delivered in such patients can be feasible and safe.
- Conditions
- Enteral Nutrition, Vasopressor Agents, Hemodynamics Instability, Critical Care
- Trial name
- NUTRIVAD (NCT03401632)
- Testing
- Enteral nutrition
- Where
- 23 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Severo Ochoa
Malnutrition or Risk of Malnutrition, Acute Respiratory Failure
Nutritional Intake in Patients on Noninvasive Ventilation: a Prospective Observational Study
The primary objective is to quantify the caloric and protein intake in adult participants with acute respiratory failure who start a noninvasive ventilation treatment.
- Trial name
- PRO-NUTRINIV (NCT06740981)
- Testing
- Food diary
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Critically Ill
IMPACT STUDY: Investigating Microbial Pathogen Activity of Copper Textiles
The purpose of this study is to assess the impact of copper linens on hospital acquired infections and drug resistant bacteria.
- Trial name
- IMPACT (NCT02627092)
- Testing
- Copper linen exposure
- Where
- 2 sites in United States
- Volunteers
- 585 people
- Sponsor
- University of Pennsylvania
Peripheral Muscle Strength
Study of Intensive Care Unit (ICU)-Acquired Weakness (Handgrip Strength Study)
To better understand ICU-acquired weakness in patients requiring mechanical ventilation in the Intensive Care Unit.
- Trial name
- NCT00702000
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Naeem Ali, MD
Any Disease Causing Death in the ICU or Within 24 Hours of Discharge From the ICU
Integrating Palliative and Critical Care (IPACC) Study
The purpose of this research study is to evaluate an intervention to improve the care given to patients who are dying in the intensive care unit (ICU) and their families.
- Trial name
- IPACC (NCT00685893)
- Testing
- Education, Local Champions, Institution Feedback
- Where
- 15 sites in United States
- Volunteers
- 3,498 people
- Sponsor
- University of Washington
COVID-19 Acute Respiratory Distress Syndrome, Viral Disease
Registry for Hemoperfusion of Covid-19 ICU Patients
The ongoing COVID-19 pandemic caused high hospitalization and mortality rates especially in critically ill patients. Unfortunately, there is no present study with a large number of patients that would offer us clear answers on…
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Viral Disease, Critical Illness, Multi Organ Failure
- Trial name
- HERICC (NCT05470907)
- Testing
- Hemoperfusion
- Where
- Croatia
- Volunteers
- 1,050 people
- Sponsor
- Croatian Society for Organ Support
Critical Illness
Reducing Discomforts in Critically Ill Patients: the IPREA3 Study
Since critically ill patients are exposed to stressful conditions, the investigators evaluated the effectiveness of a multicomponent program to reduce perceived discomforts in the Intensive Care Unit (ICU) .
- Trial name
- IPREA3 (NCT02442934)
- Testing
- Administration of the IPREA3 questionnaire, Immediate feedback through electronic reminder messages, Targeted interventions in each ICU to reduce discomforts
- Where
- 26 sites in France
- Volunteers
- 5,411 people
- Sponsor
- Dr Pierre KALFON
Critical Illness
Intrahospital Transport in Patients With High-flow Nasal Oxygenation: Prospective Observational Study
High-flow nasal oxygen therapy is commonly used in intensive care unit (ICU). Intra-hospital transfer of critical patients is frequent: 1) to perform diagnostic 2) between emergency room or medical wards and ICU.
- Trial name
- HospiFlow (NCT05311007)
- Testing
- Evaluation of the incidence and nature of adverse events
- Where
- 4 sites in France
- Volunteers
- 175 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Vancomycin
The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level
The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.
- Trial name
- NCT03806543
- Testing
- Vancomycin
- Volunteers
- 165 people
- Sponsor
- Southeast University, China
Gastric Residual Volume, Abdominal Distension
Abdominal Massage for Gastric Residual Volume in Surgical Patients
This randomized controlled trial aimed to evaluate the effect of abdominal massage on gastric residual volume (GRV) and abdominal distension in surgical intensive care patients receiving enteral nutrition.
- Conditions
- Gastric Residual Volume, Abdominal Distension, Enteral Nutrition, Massage Therapy
- Trial name
- NCT07018414
- Testing
- Abdominal Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University
Anxiety, Pain
Assessing the Impact of LIve Music in the Intensive Care Unit (ICU) to Improve Care for Critically Ill Patients
Noise in the ICU can worsen patient outcomes through factors such as increased cardiovascular stress, alteration in sleep, and increased discomfort or pain The purpose of this study is to determine the benefit of therapeutic…
- Conditions
- Anxiety, Pain, Critical Illness, Relaxation
- Trial name
- NCT03948984
- Testing
- Therapeutic Music Session
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Pragmatic Trial Examining Oxygenation Prior to Intubation
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- PREOXI (NCT05267652)
- Testing
- Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness Myopathy
Rehabilitation Following Critical Illness
The principal research question to be answered by this study is whether an exercise based rehabilitative intervention following critical illness can generate improvements in exercise capacity and quality of life beyond current…
- Trial name
- NCT00976807
- Testing
- Pulmonary Rehabilitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Surgery, Critical Illness
Sedation Optimisation Strategy (S.O.S.) Ventilation
Use of sedatives and analgesics is common in mechanically ventilated patients hospitalized in Intensive Care Unit (ICU). That is called " sedation " and aimed to reduce both pain and anxiety and also to allow an effective and…
- Conditions
- Surgery, Critical Illness, Mechanical Ventilation Complication, Organ Dysfunction Syndrome
- Trial name
- NCT01486121
- Testing
- Therapy strategy
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Muscle Wasting in Critically Ill
Protein Delivery in Intermittent and Continuous Enteral Nutrition in ICU Patients
Acute skeletal muscle wasting in ICU patients is associated with functional impairment and with increased risk of death. Of what we know today, physical disability can persist up to 5 years.
- Trial name
- ProBoNo (NCT03587870)
- Testing
- Enteral nutrition with Fresubin Intensive
- Where
- Switzerland
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Critically Ill, Respiratory Failure
A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU
Inspiratory muscle training (IMT) is an intervention used with success in the outpatient setting within the COPD population. Use of IMT is also theoretically possible during mechanical ventilation.
- Trial name
- NCT02003053
- Testing
- Inspiratory Muscle Trainer
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Wake Forest University Health Sciences
Electromyography, Ventilator Weaning
Analysis on the Fatigue and Electromyographic Activation on the Mechanical Ventilation Weaning
This study aims to evaluate respiratory muscle activation and fatigue during the mechanical ventilation weaning process using surface electromyography (sEMG).
- Conditions
- Electromyography, Ventilator Weaning, Critical Illness, Intensive Care
- Trial name
- AFAEMG (NCT07387731)
- Testing
- Sponteneous breathing test in T-tube, Sponteneous breathing test in suport ventilation (PSV)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Rio Grande do Sul
Hypoxemic Respiratory Failure, Oxygen Toxicity
Handling Oxygenation Targets in the Intensive Care Unit
Handling oxygenation targets (HOT) is standard of care in the intensive care unit (ICU), however the quality and quantity of evidence is low and potential harm has been reported.
- Trial name
- HOT-ICU (NCT03174002)
- Testing
- Oxygen
- Where
- 37 sites in Denmark, Finland and 5 more
- Volunteers
- 2,928 people
- Sponsor
- Aalborg University Hospital
Severe Sepsis
Glutamine Supplementation in Critically Ill Patients With Severe Sepsis
Severe sepsis is a common condition with high mortality and morbidity. A previous meta-analysis has demonstrated the safety of glutamine supplementation with suggestion of mortality and morbidity benefits in critically ill…
- Trial name
- CGH-GLU (NCT03048994)
- Testing
- Glutamine
- Where
- Singapore
- Volunteers
- 39 people
- Sponsor
- Changi General Hospital
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
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