Clinical trials: Critical Illness
Bacterial Infections
Early Procalcitonin Kinetics During Empirical Antibiotic Therapy in Critically Ill Patients
To investigate the value of procalcitonin (PCT) kinetics between 0-8-16-24 hours after starting empirical antibiotic therapy in critically ill patients, to predict appropriate or inappropriate antibiotic treatment.
- Trial name
- NCT02294695
- Where
- Hungary
- Volunteers
- 209 people
- Sponsor
- Domonkos Trásy
Anxiety, Depression
PARTNER II: Improving Patient and Family Centered Care in Advanced Critical Illness
This is a stepped wedged randomized controlled trial comparing the PARTNER intervention with usual care in 5 Intensive Care Units.
- Trial name
- NCT02445937
- Testing
- PARTNER II
- Where
- 2 sites in United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sepsis Induced Cardiomyopathy, Sepsis Induced Myocardial Dysfunction
Sepsis Induced Myocardial Injury in Critically Ill Children
Sepsis is a dysregulated immune response due to infection, leading to life-threatening organ dysfunction affecting respiratory, renal, immunological, digestive, neurological, and cardiovascular organs.
- Trial name
- NCT07497139
- Testing
- observational study
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Anxiety
Music for Anxiety in Critically Ill Patients
Rationale: Anxiety is common in critically ill patients, and has likely become more prevalent in the recent decade due to the imperative of the recent PADIS guidelines to use low levels of sedation and strive for wakefulness.
- Trial name
- RELACS (NCT04796389)
- Testing
- Music
- Where
- 3 sites in Netherlands
- Volunteers
- 104 people
- Sponsor
- Erasmus Medical Center
AKI - Acute Kidney Injury, Critical Illness
Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive…
- Trial name
- CIILOS (NCT07586059)
- Testing
- continuous renal replacement therapy
- Volunteers
- 500,000 people
- Sponsor
- Karolinska Institutet
Circulatory Shock
Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients
Current guidelines recommend the inititaion of noradrenaline and if shock is refractory, then vasopressin should be administered. Data indicate that the earlier use of vasopressin may improve survival.
- Trial name
- NCT06265259
- Testing
- Initiation of vasopressine as a first vasoconstrictive drug, Initiation of noradrenaline as a first vasoconstrictive drug
- Where
- Greece
- Volunteers
- 145 people
- Sponsor
- University of Thessaly
Critical Illness, Emergency Department Patient
Critical Care Admission Following Emergency Department's Resuscitation Room Care
This prospective multicenter observational study aims to describe resuscitation room activity in France and to compare critical care admission within 24 hours between patients directly admitted to the resuscitation room and those…
- Conditions
- Critical Illness, Emergency Department Patient, Shock, Trauma (Including Fractures)
- Trial name
- SAUV-IRU (NCT07411976)
- Testing
- Emergency resuscitation room management (observational)
- Where
- France
- Volunteers
- 1,629 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Critical Illness, Covid19
Psychological Impact of COVID-19 Outbreak on Caregivers
Based on the experience of previous pandemics, countries reacted by applying different upgrade strategies to prevent or delay the widespread of the disease.
- Conditions
- Critical Illness, Covid19, Stress Disorders, Post-Traumatic
- Trial name
- PSY-CO-ICU (NCT04511780)
- Testing
- questionnaire filling
- Where
- 51 sites in France
- Volunteers
- 701 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pain, Brain Injuries
Validity and Reliability Study of the Pain Indicator Behavior Scale-Brain Damage (ESCID-DC)
A multicentre observational study to validate the adaptation of the Pain Indicator Behavior Scale (ESCID) for patients with acquired Brain Damage (ESCID-DC), as a measuring instrument.
- Conditions
- Pain, Brain Injuries, Behavior
- Trial name
- ESCID-DC (NCT04898491)
- Testing
- Pain assessment using a behavioral scale
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Candelas Lopez Lopez
Delirium, Cancer
Implementation of a Delirium Screening
The purpose of this project is to improve patient outcomes in individuals affected by cancer, through the implementation of a delirium screening and treatment protocol in the ICU setting.
- Conditions
- Delirium, Cancer, Bone Marrow Ablation
- Trial name
- NCT03360474
- Testing
- Delirium Screen
- Sponsor
- University of Miami
Pneumonia, Ventilator-Associated, Stenotrophomonas Infection
Pneumonia Due to Stenotrophomonas Maltophilia in ICUs
Pneumonia is a major cause of ICU admission, or may complicate ICU course. Among the causative pathogens, Stenotrophomonas Maltophilia is a rare pathogen, but affects usually patients with chronic pulmonary co-morbidities, or…
- Conditions
- Pneumonia, Ventilator-Associated, Stenotrophomonas Infection, Critical Illness, Pneumonia, Bacterial
- Trial name
- RETROSTENO (NCT03506191)
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Covid19, Critical Illness
Early Occupational Therapy in Mechanical Ventilated Patients With Covid-19
This study evaluates the feasibility of an early occupational therapy (OT) protocol in critical adult patients requiring mechanical ventilation with Covid-19.
- Conditions
- Covid19, Critical Illness, Impairment, Cognitive, Impairment, Coordination
- Trial name
- NCT04904497
- Testing
- Early Occupational Therapy
- Where
- Chile
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Chile
Acute Kidney Injury
Citrate Versus Heparin Anticoagulation in Continuous Venovenous Hemofiltration
The purpose of this study is to compare citrate regional anticoagulation with systemic heparinization in continuous venovenous hemofiltration.
- Trial name
- CASH-CVVH (NCT00209378)
- Testing
- regional anticoagulation with citrate, HfCitPre
- Where
- 9 sites in Netherlands
- Volunteers
- 139 people
- Sponsor
- Universitair Ziekenhuis Brussel
Peritonitis, Pneumonia
ZAVI APD ELF Protocol v2.2
CAZ/AVI is a new antibiotic drug that is meant to be used for various indications including cIAI and nosocomial pneumonia. To date, limited data exists on PK of CAZ/AVI in patients undergoing peritoneal dialysis as well as on…
- Trial name
- NCT03790176
- Testing
- Intravenous Infusion
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Markus Zeitlinger
Deep Venous Thrombosis
Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial
The purpose of this phase 2a, multi-center, randomized controlled study, is to explore the efficacy of early prophylaxis against catheter-associated deep venous thrombosis (CADVT) in critically ill children.
- Trial name
- CRETE (NCT03003390)
- Testing
- Enoxaparin
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Yale University
Cancer, Critical Care, Cancer Critically Ill
Admission, Triage, and Discharge Criteria for Oncological Patients in the Intensive Care Unit
This study will create one agreed set of rules to help doctors decide which people with cancer should be treated in an intensive care unit (ICU), and when they are well enough to leave it.
- Trial name
- ONCO-TRIAD (NCT07809490)
- Testing
- No Intervention: Observational Cohort
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Onco Critical Care Society
Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism
Cerebral Microemboli in Venoarterial ECMO Patients
Extracorporeal membrane oxygenation (ECMO) is progressively used in critically ill patients with cardiac or respiratory failure as a bridging option for potential organ recovery.
- Conditions
- Complication of Extracorporeal Membrane Oxygenation, Cerebral Microembolism, Cerebral Perfusion
- Trial name
- NCT02020759
- Testing
- Transcranial Doppler Ultrasound
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Intensive Care Unit Syndrome, Post-intensive Care Syndrome
Neurological Blood-based Biomarkers and Cognitive Disorders in Critically Ill Survivors.
Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β…
- Conditions
- Intensive Care Unit Syndrome, Post-intensive Care Syndrome, Cognitive Disorder
- Trial name
- COGNISI (NCT05953311)
- Testing
- Blood analysis, Cognitive tests
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University of Liege
Acute Kidney Failure
Pharmacokinetics of Ertapenem in Continuous Venovenous Hemodialysis
Critically ill patients in the intensive care unit often receive continuous hemodialysis to treat their kidney failure. Ertapenem is an antibiotic often used in these patients.
- Trial name
- NCT00877370
- Testing
- ertapenem
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Respiration, Artificial, Mechanical Ventilation
Continuous Evaluation of Diaphragm Function
Aim of mechanical ventilation is to improve gas exchange and to unload the respiratory muscles delivering a form of mechanical support to the ventilation.
- Conditions
- Respiration, Artificial, Mechanical Ventilation, Critical Illness
- Trial name
- NCT03941002
- Testing
- Assesment of diaphragm function
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Milan