Clinical trials: Critically Ill, Mechanically Ventilated
Mechanically Ventilated Patients
Early Directed Physical Therapy in the Management of Mechanically Ventilated Patients in a Medical Intensive Care Unit
To study all ICU patients with an independent baseline functional status, who experience a critical illness requiring intubation and mechanical ventilation, evaluating the role of protocol-directed, early physical and…
- Trial name
- NCT00322010
- Testing
- early PT OT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Chicago
Trauma, Traumatic Injury
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in…
- Conditions
- Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
- Trial name
- EPO-TRAUMA (NCT04588311)
- Testing
- Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9%
- Where
- 41 sites in Australia, Belgium and 7 more
- Volunteers
- 2,500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critical Illness, Communication
Communication With Mechanically Ventilated Intensive Care Patients
The overarching aim of this multicenter study is to develop a multimodule training intervention (COMMEC-ICU) for nurses working in ICUs, to increase nurses skills and knowledge and then improve communication for mechanically…
- Conditions
- Critical Illness, Communication, Intensive Care Unit Syndrome
- Trial name
- COMMEC-ICU (NCT06977555)
- Testing
- Communication Course and skills training
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Respiratory Distress Syndrome, Adult, Critical Illness
Measuring Heart and Lung Function in Critical Care
This is a feasibility study of the use of a novel technique called 'Inspiwave' to measure heart and lung function in adult patients in critical care.
- Conditions
- Respiratory Distress Syndrome, Adult, Critical Illness, Mechanical Ventilation Complication, Haemodynamic Instability
- Trial name
- NCT03424798
- Testing
- Inspiwave
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Long-term Sedation for Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Remimazolam vs Propofol for Long-Term Sedation in Mechanically Ventilated ICU Patients
This multicenter, randomized, controlled, non-inferiority trial is designed to determine whether remimazolam is non-inferior to propofol for prolonged sedation in adult ICU patients requiring mechanical ventilation for ≥48 hours.
- Trial name
- RePro-ICU (NCT07880548)
- Testing
- Remimazolam group, Propofol group
- Where
- 21 sites in China
- Volunteers
- 274 people
- Sponsor
- Sun Yat-sen University
Critically Ill Mechanically Ventilated Subjects
The DIVINE Study: DIetary Management of Glucose VarIability iN thE ICU
To compare the nutritional effect on blood glucose of two commercially available enteral diets in overweight or obese patients in the Intensive Care Unit.
- Trial name
- NCT02337556
- Testing
- Peptamen Bariatric, Replete
- Where
- 7 sites in United States, Canada
- Volunteers
- 106 people
- Sponsor
- Société des Produits Nestlé (SPN)
Critical Illness, Mechanical Ventilation
Metabolic Response to Supine Physiotherapy in Mechanically Ventilated ICU Patients
Critically ill patients who require mechanical ventilation frequently experience rapid loss of muscle mass and physical function during their stay in the intensive care unit (ICU).
- Conditions
- Critical Illness, Mechanical Ventilation, Intensive Care Unit-Acquired Weakness, Physical Rehabilitation in the Intensive Care Unit
- Trial name
- NCT07361419
- Testing
- Supine Physiotherapy Session
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Extremadura
Critical Illness
An Assessment of the Feasibility and Safety of Conservative Oxygen Therapy in Critically Ill Patients
The investigators hypothesize that it is feasible and safe to deliver a conservative approach to oxygen therapy in mechanically ventilated critically ill patients (a tiem frame of, on average,10 days).
- Trial name
- NCT01684124
- Testing
- conservative O2 therapy, standard care
- Where
- Australia
- Volunteers
- 105 people
- Sponsor
- Austin Health
Acute Kidney Failure, Mechanical Ventilation Strategies
Driving Pressure Optimization, RV-PA Coupling, and AKI in Mechanically Ventilated Critically Ill Patients
This study evaluates the effect of driving pressure optimization on right ventricular-pulmonary artery (RV-PA) coupling, assessed by TAPSE/PASP ratio, and its association with acute kidney injury (AKI) progression in mechanically…
- Conditions
- Acute Kidney Failure, Mechanical Ventilation Strategies, Right Ventricular (RV) Dysfunction, Critical Illness
- Trial name
- NCT07836387
- Testing
- Driving Pressure-Guided Ventilator Optimization
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nardin Aymn Boshra
Mechanical Ventilation Weaning From Mechanical Ventilation Extubation Failure Critical Illness
Delta Pocc During Spontaneous Breathing Trial to Predict Extubation Failure in Mechanically Ventilated Adults (DELTA-EXT)
This prospective observational single-center study will evaluate whether dynamic respiratory stress estimated by delta airway occlusion pressure deflection (Delta Pocc) during a standardized spontaneous breathing trial can…
- Trial name
- DELTA-EXT (NCT07634783)
- Testing
- Delta Pocc Measurement During Spontaneous Breathing Trial
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Sanatorio Parque, Argentina
Ankle Contracture, Critically Ill Intensive Care Unit Patients
Continuous Passive Motion to Prevent Ankle Contracture and Muscle Atrophy in Ventilated Patients
This clinical trial aims to evaluate whether continuous passive motion (CPM) can prevent ankle joint contracture and muscle atrophy in critically ill patients receiving mechanical ventilation in the ICU.
- Conditions
- Ankle Contracture, Critically Ill Intensive Care Unit Patients, Muscle Atrophy
- Trial name
- CPM-ICU (NCT07032051)
- Testing
- Continuous Passive Motion
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Critical Illness, Mechanical Ventilation
Effects of Music Therapy on Reducing Delirium in Mechanically Ventilated Adults in Intensive Care Unit
Background: Delirium is a common acute confusion state in patients in intensive care units (ICUs). It has been linked to poor clinical prognoses (e.g., prolonged ICU stay) in critical patients.
- Trial name
- NCT04065256
- Testing
- Personalized music, Personalized music plus earplug
- Where
- Taiwan
- Volunteers
- 63 people
- Sponsor
- Taipei Medical University
Critical Illness, Intensive Care Unit Acquired Weakness
PRotEin Provision in Critical IllneSs
Rapid skeletal muscle wasting during critical illness had a detrimental impact on both short and long term outcomes following ICU admission.
- Trial name
- PRECISe (NCT04633421)
- Testing
- PRECISe protocol EN 8g protein/100kcal, PRECISe protocol EN 5g protein/100kcal
- Where
- 10 sites in Belgium, Netherlands
- Volunteers
- 935 people
- Sponsor
- Maastricht University Medical Center
Pneumonia, Ventilator Associated
Pilot Study of Lateral Rotation Interventions for Efficacy and Safety in ICU Care
Intensive care unit (ICU) patients on respirators are at high risk for preventable pulmonary complications (PPC). Turning these patients from side to side may reduce PPC, but carries the burden of decreases in blood pressure and…
- Trial name
- NCT00542321
- Testing
- Manual turn, kinetic therapy bed
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston
Surgery, Critical Illness
Predictive Ability of PEEP Induced Changes in CVP to Predict Volume Responsiveness in Mechanically Ventilated Patients After Major Abdominal Surgery
Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major…
- Conditions
- Surgery, Critical Illness, Cardiac Output, Low
- Trial name
- NCT04191408
- Testing
- PEEP increase
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
Ventilator-induced Diaphragm Dysfunction, Ventilator Dependence
Shenfu Injection for the Prevention and Treatment of Ventilator Dependence in Mechanically Ventilated Patients
This multicenter randomized controlled trial aims to evaluate the efficacy of Shenfu Injection in preventing and treating ventilator dependence and ventilator-induced diaphragm dysfunction (VIDD) in critically ill adult patients…
- Conditions
- Ventilator-induced Diaphragm Dysfunction, Ventilator Dependence, Ventilator Weaning
- Trial name
- NCT07880977
- Testing
- Shenfu Injection, 5% glucose injection
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Dyspnea During Mechanical Ventilation
Automatic Detection of Dyspnea in Mechanically Ventilated, Critically Ill Patients
The investigators will conduct a prospective, observational, two-center ICU study of 60 subjects on mechanical ventilation with respiratory failure of any cause.
- Trial name
- NCT07205952
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas José de San Martín
Mechanical Ventilation Complication, Ventilator Induced Lung Injury
Mechanical Power and Mortality in Mechanically Ventilated Adults
This prospective observational cohort study aims to investigate the relationship between mechanical power during the first 72 hours of invasive mechanical ventilation and 28-day mortality in mechanically ventilated adult patients…
- Conditions
- Mechanical Ventilation Complication, Ventilator Induced Lung Injury, ARDS, ICU Mortality (Survival Rate)
- Trial name
- NCT07836153
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Zagazig University
Delirium, Cognitive Impairment
The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status
A combined strategy of Richmond Agitation and Sedation Scale (RASS) clinical targeting plus bispectral index (BIS) guided sedation in mechanically ventilated, critically ill patients will decrease time on mechanical ventilation…
- Conditions
- Delirium, Cognitive Impairment, Critically Ill
- Trial name
- SOMNUS (NCT00469482)
- Testing
- Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center