Clinical trials: Critically Ill, Mechanically Ventilated
Mechanical Ventilation, Complication
Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients
The purpose of this study was to evaluate effects, safety and cost of midazolam used alone or sequential use of midazolam and propofol/dexmedetomidine for long-term sedation in critically ill, mechanically ventilated patients.
- Conditions
- Mechanical Ventilation, Complication, Delirium
- Trial name
- NCT02528513
- Testing
- midazolam, Fentanyl, propofol
- Where
- China
- Volunteers
- 240 people
- Sponsor
- West China Hospital
Critically Ill Patients, Mechanically Ventilated Patients
Oral Melatonin in Critically Ill High-risk Patients
Sleep disruptions are extremely common in high-risk critically ill patients. The investigators want to analyse oral melatonin potentialities as a sedative and a free-radicals scavenger for critically ill patients, and secondarily…
- Trial name
- NCT00470821
- Testing
- Oral melatonin 3mg BID
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- University of Milan
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Critical Illness
Ultrasound-guided Axillary Artery vs Femoral Artery Cannulation.
The main purpose of the study is to compare two ultrasound-guided arterial cannulation procedures: in-plane infraclavicular axillary artery cannulation and out-of-plane femoral artery cannulation.
- Trial name
- AxFemArt (NCT02801825)
- Testing
- Real-time ultrasound-guided in-plane infraclavicular axillary artery cannulation., Real-time ultrasound-guided out-of-plane femoral artery cannulation.
- Where
- Poland
- Volunteers
- 110 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Delirium
Polypharmacy-related Adverse Events in Critically Ill Children
The purpose of this study is to learn how 2 medications (fentanyl and dexmedetomidine) affect how sick children think and interact with their environments.
- Trial name
- NCT03293927
- Testing
- Fentanyl, Dexmedetomidine
- Where
- United States
- Sponsor
- Duke University
Delirium, Critical Illness
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs.
- Conditions
- Delirium, Critical Illness, Sedation Complication, Executive Dysfunction
- Trial name
- mini-MENDS (NCT04801589)
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Sleep Deprivation
Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients
The goal of this project is to determine whether the sleep and circadian rhythms of critically ill patients undergoing mechanical ventilation can be improved through practical strategies that can be employed at the bedside.
- Conditions
- Critical Illness, Sleep Deprivation, Respiratory Failure, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01284140
- Testing
- Sleep and circadian rhythm promotion, Usual care
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Brian Gehlbach
ICU-acquired Weakness, Mechanical Ventilation
eCASH and Early Goal-Directed Mobilization to Prevent ICU-Acquired Weakness
This single-center, prospective, randomized controlled trial aims to evaluate whether an eCASH concept-based analgesia and sedation strategy combined with early goal-directed mobilization can reduce the incidence of intensive…
- Conditions
- ICU-acquired Weakness, Mechanical Ventilation, Critical Illness
- Trial name
- eCASH-EGDM (NCT07677488)
- Testing
- eCASH-Based Analgesia and Sedation Strategy Combined With Early Goal-Directed Mobilization, Routine ICU Nursing Care
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Critically Ill, Cardiac Disease
Respired Gases in Patients Post Cardiac Surgery
Certain diseases relating to the heart can only be definitively treated with surgery. When untreated, these can lead to heart failure with a lack of supply of oxygen-rich blood to the tissues, leading to damage to other organs.
- Conditions
- Critically Ill, Cardiac Disease, Mitral Valve Disease
- Trial name
- REGAPS (NCT05531253)
- Testing
- Data collection using the Optical Gas Analyser
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Oxford
Low Blood Pressure, Delirium
Vasopressor SAT Study
To assess the impact of daily awakening from sedation on the amount of vasoactive medication required in the ICU. The hypothesis of this proposal is that the amount of vasoactive drug required to maintain an adequate mean…
- Conditions
- Low Blood Pressure, Delirium, Critical Illness
- Trial name
- NCT03182335
- Testing
- sedation awakening trial
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Chicago
Critical Illness, Sedation
Analgosedative adjuncT keTAmine Infusion iN Mechanically vENTilated ICU Patients
The purpose of this study is to investigate the efficacy and safety of a low dose ketamine infusion used in combination of standard of care in critically ill patients to test whether ketamine can help to shorten the time of being…
- Conditions
- Critical Illness, Sedation, Mechanical Ventilation
- Trial name
- ATTAINMENT (NCT04075006)
- Testing
- Ketamine
- Where
- Saudi Arabia
- Volunteers
- 84 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Polyneuropathy
Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.
Even 20-50% of patients under sedation and mechanical ventilation develops myopathy and / or neuropathy which difficulties both the process of extubation and the functional recovery.
- Trial name
- NCT02033057
- Testing
- Muscular electrostimulation and percutaneus muscular biopsy.
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitario La Fe
Critical Illness, Malabsorption Syndromes
The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care (ENTERIC) Study
This is a multi-centre randomised controlled trial comparing early jejunal feeding (using a frictional nasojejunal [NJ] tube) and standard feeding in critical illness.
- Trial name
- ENTERIC (NCT00163813)
- Testing
- Early jejunal feeding (using frictional NJ tube), Standard feeding (using nasogastric [NG] tube)
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- Bayside Health
Critically Ill, Mechanical Ventilation
The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))
This study is a prospective cohort study to evaluate the long-term effects of early activity and mobilisation compared to standard care on disability, function and health status for patients at 1, 2 and 5 years after recruitment…
- Conditions
- Critically Ill, Mechanical Ventilation, Long Term Outcome
- Trial name
- NCT05298982
- Testing
- Early activity and Mobilisation Intervention
- Where
- 16 sites in Australia
- Volunteers
- 250 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Sedation, Critical Illness
Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients
This randomized clinical trial evaluates the effects of a musical intervention on hormonal and inflammatory biomarkers in sedated adult patients undergoing invasive mechanical ventilation in an intensive care unit.
- Conditions
- Sedation, Critical Illness, Respiration, Artificial, Inflammation
- Trial name
- NCT06120660
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Oviedo
Critical Illness, Respiratory Failure
Targeted OXYgen Therapy in Critical Illness
The investigators propose to conduct a feasibility, multi-centre, randomised controlled trial of targeted oxygen therapy in adult critically ill patients receiving mechanical ventilation via an endotracheal tube as part of their…
- Trial name
- TOXYC (NCT03287466)
- Testing
- Oxygen
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Respiratory Failure, Critical Illness
Jet or Vibrating Mesh Nebulisation for Secretion Management in ICU
Critically unwell patients in Intensive Care have a decreased ability to effectively clear secretions. High secretion load is a major risk factor in the failure of tracheal extubation failure and the requirement for reintubation.
- Trial name
- NCT05635903
- Testing
- Continuous nebulisation 0.9% saline Aerogen Solo vibrating mesh Nebuliser, Intermittent nebulisation 0.9% saline Aerogen vibrating mesh Solo Nebuliser, Intermittent standard intermittent nebulisation of 0.9% saline Intersurgical Cirrus 2 self sealing Jet Nebuliser
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Sepsis
Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis
Despite of a remarkable decrease in overall mortality has been achieved following the International Guidelines for Management of Sepsis and Septic Shock since 2004,the short-and long-term outcomes remain poor in critically ill…
- Trial name
- PTMVP (NCT03406494)
- Testing
- Early multicomponent physical therapy program
- Volunteers
- 800 people
- Sponsor
- Zhujiang Hospital
Tracheostomized Patients, Mechanical Ventilation Weaning
High Flow Tracheal Oxygen for Weaning of Tracheostomized Patients
In this pilot randomized controlled trial (RCT), the investigators aim to explore the feasibility of conducting a powered RCT that examines the efficacy and safety of high flow tracheal oxygen (HFTO) in weaning critically ill…
- Conditions
- Tracheostomized Patients, Mechanical Ventilation Weaning, High Flow Oxygen Therapy
- Trial name
- HFTO-WEAN (NCT07559591)
- Testing
- High-flow tracheal oxygen (HFTO), Tracheal Mask (TM)
- Where
- Saudi Arabia
- Volunteers
- 88 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Critical Illness, Mechanical Ventilation Complication
Enteral Feeding in Mechanically Ventilated Children
This prospective cohort study aims to assess enteral feeding practices and the adequacy of energy and protein delivery among mechanically ventilated children admitted to the pediatric intensive care unit.
- Trial name
- NCT07884838
- Volunteers
- 60 people
- Sponsor
- Assiut University