Clinical trials: Critically Ill
Critically Ill Patients With ECMO
Imipenem in Critically Ill Patients
Extracorporeal membrane oxygenation (ECMO) has become increasingly used for lifesaving respiratory and/or cardiac failure support in critically ill patients, including those with life-threatening severe infections.
- Trial name
- NCT03776305
- Testing
- Imipenem
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Prince of Songkla University
Critically Ill Patients
Impact of Capillary Leak and Hypoalbuminemia on PK/PD of Anidulafungin and Caspofungin in Critically Ill Patients
This prospective study will explore the pharmacokinetic exposure and pharmacodynamics of the echinocandins (caspofungin or anidulafungin) in critically ill patients.
- Trial name
- NCT04045366
- Testing
- Sample collection
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Critically Ill, Hyperglycemia
Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 2
The Purpose of this study is to: 1. Introduce the refined, validated, and safe computerized bedside decision support tool for blood glucose management in critically ill adult and pediatric ICU patients that was studied in Phase 1…
- Trial name
- NCT00654797
- Testing
- glucose control with computer generated recommendations
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Intermountain Health Care, Inc.
COVID-19
Clinical Research of Human Mesenchymal Stem Cells in the Treatment of COVID-19 Pneumonia
The COVID-19 pneumonia has grown to be a global public health emergency since patients were first detected in Wuhan, China, in December 2019, which spread quickly to worldwide and presented a serious threat to public health.
- Trial name
- NCT04339660
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Puren Hospital Affiliated to Wuhan University of Science and Technology
Pain Management, Critical Illness
Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients.
This study investigates how well fentanyl is absorbed through the skin when delivered via a transdermal patch in critically ill surgical ICU patients.
- Trial name
- NCT06966869
- Testing
- Transdermal fentanyl patch
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Acute Heart Failure, Acute Renal Failure
Bladder Pressure Predicting Renal Failure in Critically Ill Patients as Compared to Hemodynamic Parameters
Studies have shown that more than 30% of the overall acute decompensated heart failure (ADHF) patients develop renal dysfunction.
- Trial name
- NCT01363505
- Testing
- BARD® Intra-abdominal Pressure monitor
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwell Health
Stress Hyperglycemia
Incidence and Course of Stress Hyperglycemia in Critically Ill Children Admitted to PICU of Assiut University Children Hospital
Detection of the prevelance of stress hyperglycemia in patients admitted to pediatric intensive care unit of Assiut university children hospital , asses its pattern ,course ,risk factors, its relation to the outcome and its…
- Trial name
- NCT04591561
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sepsis
Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis
Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU…
- Trial name
- Aminoside_II (NCT02898961)
- Testing
- 30 mg/kg amikacin or 8 mg/kg gentamicin
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Aortic Aneurysm, Gastrointestinal Dysfunction
Gastrointestinal Dysfunction in Aortic Surgery Patients
The goal of this observational study is to determine the association of gastrointestinal dysfunction through the Gastrointestinal Dysfunction Scale (GIDS) tool and serum concentrations of citrulline and Intestinal fatty-acid…
- Conditions
- Aortic Aneurysm, Gastrointestinal Dysfunction, Aortic Diseases, Enteral Feeding Intolerance
- Trial name
- NCT06514170
- Testing
- No intervention
- Where
- Mexico
- Volunteers
- 114 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Weakness Acquired in the ICU, Muscle Wasting
Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients
This cross-sectional study aims to investigate the relationship between variations in muscle thickness and subcutaneous tissue, measured by ultrasound, and fluid compartments, evaluated using bioelectrical impedance analysis…
- Conditions
- Weakness Acquired in the ICU, Muscle Wasting, Edema, Fluid Overload
- Trial name
- NCT06697470
- Testing
- Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Dr F Duprez
Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Transbronchial Lung Cryobiopsy in Undiagnosed Acute Respiratory Failure
In patients with acute hypoxemic respiratory failure whose diagnosis is not established after initial evaluation, obtaining a histopathological diagnosis may improve the patients' prognosis.
- Trial name
- NCT05754866
- Testing
- Transbronchial lung cryobiopsy, Transbronchial lung biopsy
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Critical Illness, Delirium in the Intensive Care Unit
Pilot Feasibility Study of a Pragmatic Mixed-Methods Randomized Controlled Trial on a Follow-Up Bundle of Care for ICU Survivors and Caregivers
~80% of ICU survivors experience profound long-term cognitive, physical, and psychiatric impairments known as post-intensive care syndrome (PICS).
- Trial name
- IMPACT-ICU (NCT06681649)
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Queen's University
Critical Illness, Family Members
Addressing Palliative Care Needs Among Intensive Care Unit Family Members
The quality of palliative care is highly variable for many patients treated in intensive care units (ICUs) and their family members.
- Conditions
- Critical Illness, Family Members, Psychological Distress, Informal Caregivers
- Trial name
- ICUconnect (NCT03506438)
- Testing
- Needs-focused mobile app, Usual care
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Duke University
COPD Exacerbation
Non-inferiority Evaluation of Trimbow in Critically Ill Patients Admitted in ICU Compared to Standard of Care
Objective: To evaluate non-inferiority of Trimbow, an approved therapy for treatment of severe COPD, in ICU compared to the standard of care which is based on the same therapeutic approach.
- Trial name
- TRIMICU (NCT04737655)
- Testing
- TRIMBOW® pressurised inhalation solution: Beclometasone dipropionate / formoterol fumarate /glycopyrronium 87/5/9 µg per inhalation
- Volunteers
- 200 people
- Sponsor
- PARZIBUT Gilles
Hyperglycemia in Critically Ill Patients
The Accuracy of Continuous Glucose Monitoring Systems in Critically Ill Patients
Abstract: Hyperglycemia, hypoglycemia, and glucose variability in ICU patients are associated with adverse outcomes. Continuous Glucose Monitoring Systems (CGMS) offer dynamic glucose monitoring and early warnings to improve…
- Trial name
- NCT07201155
- Testing
- Continuous Glucose Monitoring Systems, Continuous Glucose Monitoring, CGMS
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Severe Sepsis
Zinc Therapy in Critical Illness
Sepsis is a clinical syndrome often caused by a bloodstream infection that results in a common set of symptoms termed systemic inflammatory response syndrome (SIRS).
- Trial name
- NCT01162109
- Testing
- Zinc sulfate
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Weakness, Muscle
Muscular Ultrasound and Production of ICUAW
Skeletal muscle weakness is a common complication of acute respiratory failure, shock and other manifestations of critical illness or injury.
- Trial name
- MUICUAW (NCT04864093)
- Testing
- muscular ultrasound
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- University of Milan
Critical Illness Myopathy
Effects of Neuromuscular Electrical Stimulation on Exercise Capacity in Respiratory Critically Ill Patients
Neuromuscular electrical stimulation (NMES) implemented during the intensive care unit(ICU) stay may improve exercise capacity and prevent muscular weakness in critically ill patients with respiratory disease.
- Trial name
- NCT03083652
- Testing
- Neuromuscular electrical stimulation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Clinic of Barcelona
Bacteremia
Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltration
The purpose is to investigate daptomycin pharmacokinetics in critically ill patients with suspected or verified bacteremia with Gram-positive cocci undergoing combined continuous hemodiafiltration at a filtration rate of…
- Trial name
- NCT01171547
- Testing
- Daptomycin
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Shock, Cardiovascular Diseases
Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery
This study will examine the differences in microcirculatory function and mitochondrial respiration in patients with shock after cardiovascular surgery.
- Conditions
- Shock, Cardiovascular Diseases, Critical Illness
- Trial name
- MicroRESUS (NCT05330676)
- Testing
- coronary artery bypass grafting, valve repair/replacement
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Pennsylvania