Clinical trials: Critically Ill Acute Kidney Injury
Acute Kidney Injury, Sepsis
Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT
Brief Summary: Evaluating a New Phosphate-Containing Fluid for Blood Purification (CRRT) Why is this study being done? Patients in the Intensive Care Unit (ICU) often need a treatment called Continuous Renal Replacement Therapy…
- Conditions
- Acute Kidney Injury, Sepsis, Critically Ill Patients Requiring Continuous Renal Replacement Therapy
- Trial name
- PHOS-CRRT (NCT07550894)
- Testing
- Phosphate-containing Replacement Fluid, Standard Phosphate-free Replacement Fluid
- Where
- 15 sites in China
- Volunteers
- 220 people
- Sponsor
- Sun Yat-sen University
Dialysis, Critically Ill Acute Kidney Injury
Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America
This is an international, multicenter, observational study aimed at investigating acute kidney injury requiring renal replacement therapy (AKI-RRT) in Latin American countries.
- Conditions
- Dialysis, Critically Ill Acute Kidney Injury, Renal Replacement Therapy for Acute Kidney Injury in ICU, Acute Kidney Injury
- Trial name
- LATAM-AKID (NCT07262320)
- Where
- 15 sites in Bolivia, Brazil and 7 more
- Volunteers
- 1,000 people
- Sponsor
- University of Alabama at Birmingham
Fluid Balance, Acute Kidney Injury
Fluid Balance in Acute Kidney Injury in Critically Ill Patients
This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults.
- Conditions
- Fluid Balance, Acute Kidney Injury, Critically Ill Acute Kidney Injury, Critically Ill
- Trial name
- NCT07338734
- Volunteers
- 120 people
- Sponsor
- Assiut University
Critically Ill, Acute Kidney Injury
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury
The purpose of this study is to assess the efficacy of calcifediol (25-hydroxyvitamin D) and calcitriol (1,25-dihydroxyvitamin D) in preventing and reducing the severity of acute kidney injury (AKI) in critically ill patients.
- Trial name
- ACTIVATE-AKI (NCT02962102)
- Testing
- Calcifediol, Calcitriol
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- David Leaf
Validity, Renal Artery Duplex
The Validity of the Evaluation of Renal Artery Duplex in Critically Ill Acute Kidney Injury Patients
This study aims to assess the clinical relevance of renal artery duplex ultrasound in critically ill patients with acute kidney injury (AKI) in terms of the renal resistive index (RRI).
- Conditions
- Validity, Renal Artery Duplex, Critically Ill Acute Kidney Injury
- Trial name
- NCT07073508
- Testing
- Renal Artery Duplex
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Critically Ill Patients, Nutritional Support
Impact of Comprehensive Rehabilitation Nursing Combined With Refined Airway Management and Nutritional Support on Prognosis and Care Delivery Models in Critically Ill Patients
This combined intervention protocol effectively improves the prognosis of critically ill patients and optimizes nursing management models
- Conditions
- Critically Ill Patients, Nutritional Support, Pulmonary Infections, Gastrointestinal Bleeding
- Trial name
- NCT07025941
- Testing
- Standard Critical Care Nursing Protocol, ICU-PRO Nursing Protocol (Integrated Critical Care Protocol for Rehabilitation Outcomes)
- Where
- China
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Taizhou Hospital of Traditional Chinese Medicine
Critically Ill, Acute Kidney Injury
Remote Ischemic Preconditioning in Septic Patients
Acute kidney injury is a well-recognized complication in critically ill patients. Up to date there is no clinically established method to reduce the incidence or the severity of acute kidney injury.
- Conditions
- Critically Ill, Acute Kidney Injury, Sepsis
- Trial name
- RIPC-ICU (NCT05830669)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Universität Münster
Critically Ill, Acute Kidney Injury
Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation
The primary objectives of the BiPhox-Trial are to demonstrate, that the use of Biphozyl® as a replacement fluid in adult critically ill acute kidney injury (AKI) patients, results in a lower rate of pH excursions and of…
- Conditions
- Critically Ill, Acute Kidney Injury, Renal Replacement Therapy, Continuous Renal Replacement Therapy
- Trial name
- NCT04071171
- Testing
- CVVH with Phoxilium® in the first 48h after randomization, CVVH with Biphozyl® in the first 48h after randomization, CVVH with Phoxilium® in the second 48h after randomization (after previous 48h with Biphozyl®)
- Where
- Austria
- Volunteers
- 88 people
- Sponsor
- Medical University Innsbruck
Acute Kidney Injury, Critically Ill
Ultrasound to Evaluate Acute Kidney Injury
Acute kidney injury is a common complication in critically ill patients. This condition can significantly prolong the length of hospital stay, increase the cost of hospitalization, and have a high mortality rate and a poor…
- Trial name
- NCT06241417
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Southeast University, China
Critically Ill, Nutrition Disorders
Early Goal Nutrition Therapy Guided by Indirect Calorimetry and Nitrogen Balance Among Critically Ill Patients With Acute Kidney Injury (ENGINE Study)
The goal of this clinical trial is to investigate the effects of nutrition therapy guided by indirect calorimetry and nitrogen balance among critically ill patients with acute kidney injury.
- Conditions
- Critically Ill, Nutrition Disorders, Acute Kidney Injury
- Trial name
- ENGINE (NCT06238674)
- Testing
- indirect calorimetry and nitrogen balance, Indirect calorimetry (Standard care nutrition arm)
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Wankawee Jeerangsapasuk
Critically Ill, Intra-Abdominal Hypertension
The Influence of Fluid Removal Using Continuous Venovenous Hemofiltration (CVVH) on Intra-abdominal Pressure and Kidney Function
Intra- abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are a cause of organ dysfunction in critically ill patients.
- Conditions
- Critically Ill, Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury
- Trial name
- NCT01077895
- Testing
- CVVH, ultrafiltration, ultrafiltration control group
- Where
- 2 sites in Belgium
- Sponsor
- University Hospital, Ghent
Acute Kidney Injury, COVID-19
Incidence of Acute Kidney Injury in Covid-19
Acute kidney injury (AKI) in Covid-19 patients is a topic that receives little attention in the literature, although being important in clinical practice in the ICU, particularly in Oman.
- Conditions
- Acute Kidney Injury, COVID-19, Critically Ill
- Trial name
- COVIDAKI (NCT05467956)
- Testing
- Covid-19
- Where
- Oman
- Volunteers
- 286 people
- Sponsor
- Sultan Qaboos University
Iohexol, Pharmacokinetics
Renal Function Assessment in Critically Ill Children
Identification of renal dysfunction in critically ill children is often delayed due to lack of accurate methods for evaluation of glomerular filtration rate (GFR).
- Conditions
- Iohexol, Pharmacokinetics, Renal Function, Critically Ill Children
- Trial name
- IOHEXOL (NCT05179564)
- Testing
- iohexol administration, iohexol blood sampling
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Critically Ill, Acute Kidney Injury
Non-interventional Follow-up Versus Fluid Bolus in RESPONSE to Oliguria in the Critically Ill
Background: After hypotension, oliguria (urine output less than 0.5 mL/kg/h) was the most common trigger to administer fluid bolus in a multinational practice survey in intensive care.
- Conditions
- Critically Ill, Acute Kidney Injury, Sepsis, Oliguria
- Trial name
- RESPONSE (NCT02860572)
- Testing
- follow-up without intervention, fluid bolus
- Where
- 2 sites in Finland
- Volunteers
- 130 people
- Sponsor
- Helsinki University Central Hospital
Acute Kidney Injury, Critically Ill Children
Iohexol for Measuring Renal Function
Approximately 25-35% of all children admitted to the paediatric intensive care unit (PICU) or neonatal intensive care unit (NICU) will develop Acute Kidney Injury (AKI) during the first seven days after admission.
- Trial name
- HERO (NCT03946345)
- Testing
- Iohexol Inj 300 MG/ML
- Where
- Netherlands
- Volunteers
- 105 people
- Sponsor
- Radboud University Medical Center
Critically Ill, Acute Kidney Injury
Magnesium Balance of Citrate-based Continuous Venovenous Hemofiltration, Effect of Citrate Dose.
Rationale: A higher citrate dose during continuous venovenous hemofiltration provides better anticoagulation but possibly a higher risk of citrate accumulation in case of metabolic limitations.
- Trial name
- NCT02194569
- Testing
- Citrate
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Ziekenhuis Oost-Limburg
Acute Kidney Injury in Critically Ill Children
Utility of NGAL to Diagnose AKI in Critically Ill Children
Acute Kidney Injury is common in critically ill children and is associated with high morbidity and mortality in pediatric intensive care unit.
- Trial name
- NCT03034876
- Volunteers
- 140 people
- Sponsor
- Aga Khan University
Critically Ill, Cancer
Spironolactone Administration to Prevent Ischemic Kidney Injury in Critically Ill Cancer Patients
Acute kidney injury frequently affects cancer patients. The main cause of acute kidney injury is ischemic damage caused by transient decrease in renal blood flow, followed by blood flow restoration and accompanying reperfusion…
- Trial name
- SPIROCAN (NCT02531412)
- Testing
- Spironolactone
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Acute Renal Failure, SIRS
BK Virus and Renal Dysfunction in Postoperative/Posttraumatic Critically Ill Patients
The purpose of this study is to find out whether acute renal failure is associated with BK virus reactivation in postoperative/posttraumatic critically ill patients with severe SIRS/sepsis and shock.
- Conditions
- Acute Renal Failure, SIRS, Sepsis, Critically Ill
- Trial name
- BICUK (NCT00736827)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University of Ulm
Critically Ill, Acute Renal Failure
2012_PharmacoCRRT-study:Pharmacokinetics of Anti-infectives in Critically Ill Patients in Need of Continuous Renal Replacement Therapy (CRRT)
The main purpose of the study is to examine if changes in pharmacokinetics of important antiinfectives in Critically Ill patients in need of continuous renal replacement therapy (CRRT), causes inadequate concentrations in plasma.
- Conditions
- Critically Ill, Acute Renal Failure, Acute Kidney Injury
- Trial name
- PharmacoCRRT (NCT01582360)
- Where
- Norway
- Volunteers
- 640 people
- Sponsor
- Oslo University Hospital