Clinical trials: Critically Ill Child
Nutrition Assessment, Critical Illness
Indirect Calorimetry: SensorMedics Vmax vs GE Carescape - a Method Comparison Study
Dosing of nutrition in PICUs is mainly based on patient weight and assumptions on clinical status. There is however poor correlation between these calculations and actual energy consumption measured with indirect calorimetry…
- Conditions
- Nutrition Assessment, Critical Illness, Children
- Trial name
- NCT02987309
- Where
- Norway
- Volunteers
- 6 people
- Sponsor
- Oslo University Hospital
Acute Kidney Injury, Critically Ill Children
Iohexol for Measuring Renal Function
Approximately 25-35% of all children admitted to the paediatric intensive care unit (PICU) or neonatal intensive care unit (NICU) will develop Acute Kidney Injury (AKI) during the first seven days after admission.
- Trial name
- HERO (NCT03946345)
- Testing
- Iohexol Inj 300 MG/ML
- Where
- Netherlands
- Volunteers
- 105 people
- Sponsor
- Radboud University Medical Center
Intensive Care Units, Pediatric, Anesthetics, Inhalation
Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents
The goal of a pilot study is to test a study plan to see if it is appropriate for a larger study. This study plan is looking at whether the use of inhaled sedatives (medications that help people be calm and sleep) can reduce…
- Conditions
- Intensive Care Units, Pediatric, Anesthetics, Inhalation, Mechanically Ventilated, Critically Ill Children
- Trial name
- ABOVE (NCT05867472)
- Testing
- Isoflurane Inhalant Product
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute Kidney Injury
Effect of Cumulative Chloride Dose on Development of Acute Kidney Injury in Critically Ill Children
The investigators would like to investigate the effect of chloride dosing on the development of acute kidney injury in critically ill patients.
- Trial name
- NCT02188602
- Where
- United States
- Sponsor
- Stanford University
Acute Kidney Injury, Renal Replacement Therapy
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI
This study follows a group of patients admitted to the PICU who are identified as being at risk for developing acute kidney injury.
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Pediatric Intensive Care Units
- Trial name
- Taking Focus 2 (NCT03541785)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Critical Illness, Infection, Mixed
Biomarkers of Acute Serious Illness in Children
This study is a large multi-centre collaboration between a busy regional paediatric intensive care transport service (Children's Acute Transport Service, CATS), four large paediatric intensive care units (PICUs at Great Ormond…
- Conditions
- Critical Illness, Infection, Mixed, Children, Only
- Trial name
- BASIC (NCT03238040)
- Testing
- None, observational study
- Where
- 4 sites in United Kingdom
- Volunteers
- 674 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Post Operative Pain
Morphine PK Subgroup Analysis
This study was originally undertaken to evaluate the analgesic efficacy of an intravenously administered dose of ketorolac compared with intravenous morphine in the relief of acute, postoperative pain in children admitted to the…
- Trial name
- NCT01322191
- Testing
- Morphine
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
PTSD, Critical Illness
The Experiences of Children and Caregivers Given PICU Storybooks
1. To assess the acceptability and feasibility of a study design aimed at evaluating the efficacy of a newly developed intervention for children and their caregivers following discharge from PICU 2.
- Conditions
- PTSD, Critical Illness, Depression, Anxiety
- Trial name
- NCT04041401
- Testing
- PICU storybook
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Acute Kidney Injury
Predictors of Acute Kidney Injury in Critically Ill Children Admitted to PICU.
Predictors of Acute Kidney Injury in critically ill children admitted to PICU during one year.
- Trial name
- NCT06328478
- Testing
- Observational prospective study.
- Volunteers
- 100 people
- Sponsor
- Assiut University
Community Acquired Pneumonia
Clinical Pediatric Pneumonia Score in Critically Ill Children
The purpose of the study is to create a clinical pneumonia tool that can be used to predict the cause of community-acquired pneumonia, which is a lung infection that began outside of the hospital in critically ill children…
- Trial name
- NCT02139384
- Where
- United States
- Sponsor
- Loma Linda University
Sepsis, Critical Illness
Study of MSC-Exo on the Therapy for Intensively Ill Children
At present, a number of projects related to MSCs have been approved for graft-versus-host disease, myocardial infarction, Crohn's disease and other diseases, indicating a strong therapeutic potential of MSCs.
- Trial name
- NCT04850469
- Where
- China
- Sponsor
- Children's Hospital of Fudan University
Congenital Metabolic Disorder, Acute Disease
Rapid Genetic Diagnosis Employing Next Generation Sequencing for Critical Illness in Infants and Children
Under the joint efforts of genetic and intensive expert, to establish the high-throughput whole exon sequencing(WES) and analysis all the possible pathogenic genes.
- Trial name
- NCT03175692
- Testing
- Whole Exome Sequencing
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Access and Transport to Paediatric Intensive Care
Differences in Access to Emergency Paediatric Intensive Care and Care During Transport
There are fewer than 30 paediatric intensive care units (PICUs) in the United Kingdom (UK). This means that a critically ill child taken to their nearest hospital will need to be transferred to a PICU.
- Trial name
- DEPICT (NCT03520192)
- Where
- United Kingdom
- Volunteers
- 2,838 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Critical Illness
Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children
The purpose of the study is 1) to determine whether administration of intravenous zinc to critically ill children is safe, and 2) to determine an appropriate dose of zinc supplementation.
- Trial name
- NCT01062009
- Testing
- Zinc sulfate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Children
AI Based Multi-modal Parameter of Peripheral Blood Cells (MMPBC) Predicts Survival Risk in Critically Ill Children
This study aims to investigate whether an AI prediction model based on blood cell multi-modal data can achieve early warning of survival risk in critically ill children through a large-scale multi-center cohort of critically ill…
- Trial name
- NCT06034639
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Zhujiang Hospital
Pediatric Intensive Care Units
Nutritional Status of Critically Ill Children in Pediatric Intensive Care Units at Sohag University Hospitals
The goal of this observational study is to evaluate nutritional status of critically ill patients admitted to Pediatric Intensive Care Units (PICU) at Sohag University Hospital and its correlation with their outcome as regarding…
- Trial name
- NCT07041658
- Volunteers
- 100 people
- Sponsor
- Sohag University
Critically Ill Children, Nutritional Support
Relationship of Nutritional Support for Critically Ill Children With Clinical Outcomes in a Pediatric Hospital in Bolivia (NutPeBol)
The aim of this observational study is to learn about the characteristics of nutritional support in critically ill children. The primary question to be answered is Is there an association between nutritional support of the…
- Trial name
- NutPeBol (NCT06716229)
- Where
- 2 sites in Bolivia
- Volunteers
- 56 people
- Sponsor
- MPH D Raul Copana-Olmos
Critical Illness
PICU Patient Diary
The PICU-Diary study is a prospective single centre pilot study in the Pediatric Critical Care Unit at McMaster Children's Hospital.
- Trial name
- NCT03777527
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Adrenal Insufficiency, Critical Illness
Pilot Study Assessing Oxidative Stress in Children
Role fo oxidative stress in adrenal insufficiency has not been studied. The degree of oxidative stress and it's role in pediatric critical illness is unknown.
- Trial name
- OxStress (NCT01052207)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Emory University
Mechanical Ventilation Complication, Ventilator-induced Diaphragm Dysfunction
How Early Mobilization Impacts on Diaphragm Thickness in Critically Ill Children
The objective is to compare the impact of early mobilization and routine care on diaphragm thickness in critically ill children
- Trial name
- NCT04534296
- Testing
- early mobilization, routine care
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Children's Hospital of Fudan University