Clinical trials: Critically Ill Children
Acute Kidney Injury
Role of Renal Artery Doppler in Critically Ill Children With Acute Kidney Injury
To detect frequency of acute kidney injury in critically ill children in Assuit university hospital. To detect associated AKI risk factors, severity and outcomes . To assess the value of use of renal Doppler ultrasound in AKI.
- Trial name
- NCT06202326
- Testing
- renal artery doppler
- Volunteers
- 45 people
- Sponsor
- Assiut University
Traumatic Brain Injury, Critical Illness
Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin
Sleep wake disturbances compound recovery in over half of pediatric traumatic brain injury survivors, leading to impaired quality of life, and few effective interventions exist to treat this important morbidity.
- Conditions
- Traumatic Brain Injury, Critical Illness, Sleep
- Trial name
- SMARTKids (NCT04932096)
- Testing
- melatonin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Critical Illness, Pediatric Critical Illness
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit…
- Conditions
- Critical Illness, Pediatric Critical Illness, Respiratory Failure, Traumatic Brain Injury
- Trial name
- NCT07613918
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Wisconsin, Madison
Critically Ill Child, Nutritional Status
Height Measurement in Critically Ill Children
Height/length has to be assessed accurately in critically ill children, as its value is required to assess nutritional status, to calculate nutritional requirements, to calculate body surface area (involved in drug…
- Conditions
- Critically Ill Child, Nutritional Status, Height, Length
- Trial name
- EvTaRéaP (NCT03572504)
- Testing
- critically ill children
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Strasbourg, France
Adrenal Insufficiency, Critical Illness
Pilot Study Assessing Oxidative Stress in Children
Role fo oxidative stress in adrenal insufficiency has not been studied. The degree of oxidative stress and it's role in pediatric critical illness is unknown.
- Trial name
- OxStress (NCT01052207)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Emory University
Transpulmonary Pressure, Pressure.Rate Product
Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation
Typically doctors adjust the settings on the ventilator to ensure that children receive enough help to decrease the work they perform to breathe, receive enough oxygen through the machine to pass into the blood and to the organs…
- Conditions
- Transpulmonary Pressure, Pressure.Rate Product, Guide to Mechanical Ventilator Management, Extubation Readiness
- Trial name
- NCT02354365
- Testing
- Transpulmonary Pressure measurement
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Children's Hospital Los Angeles
Sepsis
Vitamin A Status in Critically Ill Children With Sepsis and Its Association With Illness Severity
The primary purpose of this study is to assess the status of vitamin A in critically ill children with sepsis and its association with the ill severity.
- Trial name
- NCT03598127
- Where
- China
- Volunteers
- 300 people
- Sponsor
- West China Hospital
Mechanically Ventilated, Critically Ill Children
Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children
There is a significant lack of adequately powered randomized clinical trial (RCT) data to determine the comparative safety and effectiveness of sedative treatments in pediatric patients.
- Trial name
- NCT04082767
- Testing
- Precedex, Midazolam
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Douglas Fraser
Critical Illness
Improving Outcomes After PICU Admission: A Pilot Study
1. Evaluate the feasibility and acceptability of an information based intervention delivered to parents following their child's admission to paediatric intensive care; 2.
- Trial name
- NCT01737021
- Testing
- Psycho-education
- Volunteers
- 31 people
- Sponsor
- Imperial College London
Delirium
Lived Experiences and Impact of Delirium in Critically Ill Children: a Qualitative Study
The investigators aim to conduct a qualitative study evaluating the long and short-term recollection and experiences of critically ill children with delirium as well as collect the lived experience of the caregiver and healthcare…
- Trial name
- NCT04168515
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Critical Illness, Depressive Symptoms
Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients
Depressive symptoms are common among patients admitted to the intensive care unit (ICU) and may adversely affect recovery, participation in care, treatment adherence, quality of life, and outcomes after critical illness.
- Trial name
- KID-ICU (NCT07639359)
- Testing
- Ketamine (0.5 mg/kg), Normal Saline (0.9% NaCl)
- Where
- 2 sites in United States, Argentina
- Volunteers
- 50 people
- Sponsor
- Hospital Italiano de Buenos Aires
Critical Illness
Modified Pediatric Early Warning Score and Modified PRISA II During COVID-19 Pandemic
One of the most important factors in pediatric emergency units is the correct decision of the patient inpatient or outpatient treatment. If the disease progresses critically, the decision of hospitalization comes to the fore.
- Trial name
- NCT04876872
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 894 people
- Sponsor
- Karadeniz Technical University
Community Acquired Pneumonia
Clinical Pediatric Pneumonia Score in Critically Ill Children
The purpose of the study is to create a clinical pneumonia tool that can be used to predict the cause of community-acquired pneumonia, which is a lung infection that began outside of the hospital in critically ill children…
- Trial name
- NCT02139384
- Where
- United States
- Sponsor
- Loma Linda University
Model Informed Precision Dosing
Model-Informed Precision Dosing on Amikacin and Vancomycin Therapy in Critically Ill Children
Achieving optimal antibiotic exposure in critically ill pediatric patients is difficult due to (their) dynamic physiology and variability.
- Trial name
- NCT07315438
- Testing
- MIPD Tool
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Hacettepe University
Respiratory Insufficiency, Pneumonia, Aspiration
Feeding Children Nasogastrically Versus Nasojejunally While Receiving Noninvasive Positive Pressure Ventilation
The investigators are studying whether it is safe and effective to provide enteral nutrition to critically ill children via the nasogastric route, as opposed to the nasojejunal route, while they are receiving noninvasive positive…
- Conditions
- Respiratory Insufficiency, Pneumonia, Aspiration, Nutrition Disorders
- Trial name
- FeedNIV (NCT01301352)
- Testing
- Route of feeding (nasogastric vs. nasojejunal)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Respiratory Infection, Fluid Overload
Fluid Restriction Keeps Children Dry
Rationale: Fluid overload is a common complication in children who are admitted to the pediatric intensive care for mechanical ventilation.
- Conditions
- Respiratory Infection, Fluid Overload, Critical Illness, Respiratory Insufficiency
- Trial name
- LESSER (NCT02989051)
- Testing
- Restrictive fluid regimen, Liberal fluid regimen
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Music Therapy, Critical Care
Music Use for Sedation In Critically Ill Children
Stress induced by pain and anxiety is common in pediatric intensive care unit (PICU) patients and can impede the delivery of care as well as their recovery.
- Conditions
- Music Therapy, Critical Care, Analgesia, Ventilators, Mechanical
- Trial name
- MUSiCC (NCT03497559)
- Testing
- Music
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Critical Illness, Enteral Feeding Intolerance
Evaluation of Enteral Nutrition in Critically Ill Children
The aim of this study was to evaluate the effect of calorie and enteral feeding timing on survival in critically ill children receiving inotropic, vasopressor and inodilatory supplements.
- Trial name
- NCT04013893
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Cukurova University
Acute Kidney Injury, Fluid Overload
Use of Biomarkers to Optimize Fluid Dosing,CRRT Initiation and Discontinuation in Pediatric ICU Patients With AKI
Acute Kidney Injury (AKI) is a common clinical problem defined by an abrupt (< 48 hour) increase in serum creatinine (SCr) resulting from an injury or insult that causes a functional or structural change in the kidney.
- Trial name
- NCT01416298
- Testing
- Continuous Renal Replacement Therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Stress Hyperglycemia
Incidence and Course of Stress Hyperglycemia in Critically Ill Children Admitted to PICU of Assiut University Children Hospital
Detection of the prevelance of stress hyperglycemia in patients admitted to pediatric intensive care unit of Assiut university children hospital , asses its pattern ,course ,risk factors, its relation to the outcome and its…
- Trial name
- NCT04591561
- Volunteers
- 100 people
- Sponsor
- Assiut University