Clinical trials: Critically Ill Intensive Care Unit Patients
Critically Ill Patients
Virtual Visitation in Intensive Care Unit Study
The purpose of this study is to identify the efficacy of virtual visitation in Intensive Care Unit on patients and their caregivers during COVID-19 Pandemic.
- Trial name
- ISEEU (NCT04962204)
- Testing
- Virtual meeting between patients/physicians and caregiver
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Enteral Feeding Intolerance, Critical Illness
Continuous Versus Intermittent Enteral Feeding and Gastric Residual Volume in Critically Ill Patients
This study will compare two commonly used methods of enteral feeding in critically ill adults: continuous feeding and intermittent feeding.
- Trial name
- NCT07876141
- Testing
- Continuous Enteral Feeding, Intermittent Enteral Feeding
- Where
- Vietnam
- Volunteers
- 76 people
- Sponsor
- Viet Duc University Hospital
Critically Ill
Diaphragmatic Function in Ventilated Patients
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called…
- Trial name
- NCT00786526
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Pediatric Cancer, Critically Ill
ONCOTIPNET: Multicenter Study on Risk Factors and Outcome in Cancer Pediatric Patients Admitted in Italian PICUs
The study will describe characteristics of pediatric cancer patients admitted to Italian PICUs and will analyze risk factors of PICU admission, neurological outcome, and mortality.
- Trial name
- ONCOTIPNET (NCT04581655)
- Where
- 17 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera di Padova
Sepsis
Red Cell Distribution Width Versus Presepsin (Soluble CD14) as a Prognostic Marker in Critically-ill Sepsis Patients
Presepsin (soluble CD14 subtype) is a novel marker with growing body of evidence supporting its accuracy and value for the diagnosis of sepsis. Patients with sepsis showed higher Prsepsin levels compared to those with SIRS.
- Trial name
- NCT03796715
- Testing
- Red Cell Distribution Width (RDW), Presepsin (sCD14-ST)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Bacterial Infections
Pharmacokinetics of Piperacillin and Tazobactam in Critically Ill Patients
Optimal understanding of piperacillin-tazobactam pharmacokinetics in critically ill patients is lacking resulting in large variation of achieved exposure and possible inadequate therapy.
- Trial name
- PICTAR (NCT03738683)
- Testing
- Piperacillin/tazobactam
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Pneumonia
Effect of High Dose Intravenous Vitamin C in Severe Pneumonia
This trial is a multicenter, randomized, double-blind, two-arm, parallel-group, placebo-controlled trial to investigate the effect of high dose intravenous (IV) Vitamin C as an adjunct to the standard of care for patients with…
- Trial name
- VICSEP (NCT05842382)
- Testing
- Active Ingredient
- Where
- 3 sites in Malaysia
- Volunteers
- 484 people
- Sponsor
- Clinical Research Centre, Malaysia
Hypomagnesemia
Dynamic Magnesium Replacement Strategies and 28-Day Mortality in Non-Cardiac Critically Ill Patients With Hypomagnesemia: A Target Trial Emulation
This study looks at how different ways of giving magnesium (a nutrient) affect the risk of death within 28 days for adults with low magnesium levels who are in the intensive care unit (ICU) for non-heart-related reasons.
- Trial name
- NCT07380542
- Where
- China
- Volunteers
- 12,887 people
- Sponsor
- Fujian Provincial Hospital
Cardiovascular Diseases, Delirium
Absent Visitors: The Wider Implications of COVID-19 on Non-COVID Cardiothoracic ICU Patients, Relatives and Staff
Patients are part of a family network. When any person in a family becomes critically unwell and requires the assistance of an Intensive Care Unit (ICU), this has an impact on all members of that family.
- Conditions
- Cardiovascular Diseases, Delirium, Critical Illness, Intensive Care Unit Delirium
- Trial name
- VINCI (NCT04538469)
- Testing
- COVID visitation restrictions
- Volunteers
- 1,000 people
- Sponsor
- University of Glasgow
Covid19, COVID-19 Pneumonia
The Long Term Effects of COVID on Pulmonary Function
An observational cohort study of patients discharged from the ICU following admission with COVID19 infection, looking at their medical wellbeing 6 months after discharge from the ICU.
- Conditions
- Covid19, COVID-19 Pneumonia, Critical Illness, Quality of Life
- Trial name
- NCT05077982
- Testing
- Spirometry, 6-minute walk
- Where
- 2 sites in Malta
- Volunteers
- 123 people
- Sponsor
- Sciberras, Stephen M.D.
Critical Illness, Covid19
Psychological Impact of COVID-19 Outbreak on Caregivers
Based on the experience of previous pandemics, countries reacted by applying different upgrade strategies to prevent or delay the widespread of the disease.
- Conditions
- Critical Illness, Covid19, Stress Disorders, Post-Traumatic
- Trial name
- PSY-CO-ICU (NCT04511780)
- Testing
- questionnaire filling
- Where
- 51 sites in France
- Volunteers
- 701 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Adult ICU Patients
Metabolic Trajectories and Protein Intake in Long-Stay Ventilated Intensive Care Unit (ICU) Patients
Survival of critically ill patients has improved, resulting in a growing population of chronically critically ill (CCI) individuals with prolonged organ dysfunction, mechanical ventilation, and high morbidity.
- Trial name
- MetaChronic (NCT07268274)
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Universidade do Algarve
Critical Illness
Predictive Model for Mortality in Older People With Critical Illness
The present study aims to develop a predictive model to identify elderly patients with the highest likelihood of mortality upon admission to an intensive care unit.
- Trial name
- VITA (NCT06727903)
- Testing
- laboratory biomarker analysis
- Where
- 15 sites in Spain
- Volunteers
- 450 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Sleep Deprivation, Critical Illness
Sleep Harmonization Via Bundled Team-Based Interventions in the ICU
SHANTI-ICU compares the effectiveness of two evidence-based multicomponent ICU sleep promotion bundles on delirium and patient-reported sleep quality in critically ill adults. Bundle A is a non-pharmacologic strategy.
- Conditions
- Sleep Deprivation, Critical Illness, Sleep-Wake Disorders, Bundle Care
- Trial name
- SHANTI-ICU (NCT07840560)
- Testing
- Nighttime noise & light reduction, Clustering patient-care interactions, Non-pharmacologic sleep aids
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 62,500 people
- Sponsor
- University of California, San Diego