Clinical trials: Critically Ill Patient
Covid19, Endothelial Dysfunction
Managing Endothelial Dysfunction in Critically Ill COVID-19 Patients at LAUMCRH
COVID-19 Infection has been found to cause endothelial dysfunction and most of the adverse events stem to this mechanism. So we seek to target endothelial dysfunction in critically Ill patients with covid by giving them an…
- Trial name
- NCT04813471
- Testing
- Endothelial Protocol
- Where
- Lebanon
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Lebanese American University Medical Center
Sepsis, Primary Myopathies
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular…
- Trial name
- NCT00735384
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Colonic Neoplasms, Rectal Neoplasms
Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy
Indications for colostomy are rectal or anal cancer, diverticular disease, radiation enteritis, complex perirectal fistulas, anorectal trauma, severe incontinence, motility and functional disorders.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Fecal Incontinence
- Trial name
- EACC (NCT02308631)
- Testing
- ENDOSCOPICALLY ASSISTED COLOSTOMY WITH COLOPEXY
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiogenic Shock,, With ECMO or IABP Support,
The Analysis of Heart Rate Variability With 24hrs Holter ECG and Serum Cardiac Fibrosis Markers in Critical Illness Patients Who Are With Cardiogenic Shock, With ECMO or IABP Support, or With APACH II Score >25)
The study is to show the prognostic factor of HRV parameter and cardiac fibrosis markers in critical illness patients
- Conditions
- Cardiogenic Shock,, With ECMO or IABP Support,, With APACH II Score >25)
- Trial name
- NCT01993745
- Where
- Taiwan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pseudomonas Infections, Pseudomonas Septicemia
Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis
The present study focuses on patients with Pseudomonas aeruginosa (PSA) sepsis. The aim of the present study is to find out whether the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype predominates in blood monocytes in…
- Conditions
- Pseudomonas Infections, Pseudomonas Septicemia, Pseudomonas; Pneumonia, Pseudomonal Bacteraemia
- Trial name
- MIPSA (NCT03044223)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulm
ICU Stay & Mortality
Observational, Prospective, Single-center Study: Should Body Mass Index (BMI) be Added to the Scoring Criteria of Hepatic Critically Ill Patients in Intensive Care Unit??
The purpose of the study is to evaluate the hypothesis of poor clinical outcomes in critically ill patients that are having abnormal BMI.
- Trial name
- NCT03461523
- Where
- Egypt
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Critical Illness, Family
Psychosocial Outcomes in Families of COVID-19 ICU Patients
During the first part of the SRAS-COV2 pandemic, families were not allowed to visit the patients in ICU. We know that families can develop "Family-PICS" after their relatives' ICU stay.
- Conditions
- Critical Illness, Family, Psychological Stress, Covid19
- Trial name
- NCT04498507
- Testing
- HADS questionnaire
- Where
- Belgium
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Liege
Malnutrition, Critical Illness
Anabolic Steroids for Nutritional Rehabilitation of Critically Ill Patients
This prospective, double-blinded study will determine the feasibility of determining the efficacy of a weekly intramuscular injection of nandrolone (an anabolic steroid) in malnourished ICU patients.The data from this study will…
- Trial name
- NCT00242463
- Testing
- Nandrolone (anabolic steroid)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Volume Overload, Tissue Perfusion
Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness
43 patients between 18-60 years presenting with criteria of sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection, suspected or documented infection and an acute increase ≥2 SOFA…
- Trial name
- NCT05104528
- Testing
- OSYPKA Medical ICONTM Noninvasive CardiometerTM Model C3, Fujifilm Sonosite M-Turbo C Ultrasound system
- Where
- Egypt
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Status Epilepticus
Status Epilepticus in the Critically Ill Patients
Convulsive and Non Convulsive Status Epilepticus (SE) and Pseudo Status Epilepticus prospective registry. Data collection using a standardized form : demographic data and data related to the SE, including circumstances of onset…
- Trial name
- NCT03457831
- Where
- 20 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ictal Group
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Airway Management, Tracheal Intubation
Curriculum for Airway Skills in Critically Ill Adults: a Delphi Evaluation
This study using a Delphi methodology, and involving international experts, will help define a training curriculum for physicians involved with airway management in critically ill patients.
- Conditions
- Airway Management, Tracheal Intubation, Critical Illness, Training
- Trial name
- CASCADE (NCT06689748)
- Testing
- Delphi procedure
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Nutrition, Critical Illness
Micronutrients in Critically Ill Patients
Nutritional support is an important component of modern critical care. The practice of vitamin and micronutrient supplementation is variable and official guidelines are not consistent.
- Conditions
- Nutrition, Critical Illness, Vitamin Supplementation
- Trial name
- MiNuCrit (NCT04136119)
- Testing
- questionnaire
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Pseudomonas Aeruginosa
Pathobiomes in Gut of Critically Ill Patients
Despite powerful antibiotics, 50% of the intestinal tracts of critically ill surgical patients are colonized by Pseudomonas aeruginosa, whose mere presence in this site increases mortality fourfold by mechanisms that remain…
- Trial name
- NCT06822465
- Testing
- P. aeruginosa using in vitro and in vivo assays
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Sleep Disturbance, Sleep Disorder
Efficacy of a Sleep Hygiene Toolkit for Patients in ARU
Sleep Hygiene Study Abstract: INTRODUCTION Sleep is integral to the health of a person and can have multifaceted contributions to a person including their physical, cognitive, and psychosocial well-being.
- Conditions
- Sleep Disturbance, Sleep Disorder, Insomnia, Critical Illness Myopathy
- Trial name
- NCT05541692
- Testing
- Sleep Hygiene Toolkit
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Coronary Artery Disease
Intravenous Fish Oil in Critically Ill Cardiac Patients
A large body of evidence has accumulated showing that n-3 PUFAs exert extensive cardiac effects. The development of commercial solutions of FO opens perspectives for therapeutic applications in patients with acute cardiac…
- Trial name
- FO-cardiac (NCT00516178)
- Testing
- Fish oil emulsion, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Critical Illness
Family Presence on Multidisciplinary Patient Care Rounds in ICU
Family presence on patient care rounds in adult intensive care units remains the least studied area of family-centered care. Despite support from professional organizations and critical care experts, very few critical care units…
- Trial name
- NCT05449990
- Testing
- Participation in PFCC-IR
- Where
- United States
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Circulatory Failure
Fluid Responsiveness Predicted by PtcO2 in Critically Ill Patients
Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of oxygen (PtcO2) in the critically ill patients.
- Trial name
- PtcO2-FR (NCT02083757)
- Where
- China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Anxiety, Depression
Improving Patient and Family Centered Care in Advanced Critical Illness
One in five deaths in the U.S. occurs in or shortly after discharge from an intensive care unit (ICU), typically following decisions made by surrogate decision makers to forego life prolonging treatment.
- Trial name
- PARTNER (NCT01844492)
- Testing
- The PARTNER Intervention, ICU Usual Care Control
- Where
- United States
- Volunteers
- 1,420 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh